Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss

Autor: Ager, RR, Davis, JL, Agazaryan, A, Benavente, F, Poon, WW, Laferla, FM, Blurton-Jones, M

Publikováno v: Ager, RR; Davis, JL; Davis, JL; Agazaryan, A; Agazaryan, A; Benavente, F; et al.(2015). Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss. Hippocampus. doi: 10.1002/hipo.22405. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5z11n0st

© 2014 The Authors. Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disorder, affecting over 35 million people worldwide. Pathologically, AD is characterized by the progressive accumulation of β-amyloid (Aβ) plaques an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::169f743fa8c0a226a5cb7df9d0bdfb7c
http://www.escholarship.org/uc/item/5z11n0st

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer's disease-like pathology.

Autor: Baglietto-Vargas D; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., Forner S; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Cai L; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Martini AC; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Trujillo-Estrada L; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., Swarup V; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Nguyen MMT; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Do Huynh K; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Javonillo DI; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Tran KM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Phan J; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Jiang S; Department of Developmental and Cell Biology, University of California, Irvine, CA, USA., Kramár EA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Nuñez-Diaz C; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., Balderrama-Gutierrez G; Department of Developmental and Cell Biology, University of California, Irvine, CA, USA., Garcia F; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Childs J; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Rodriguez-Ortiz CJ; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Division of Occupational and Environmental Medicine, Department of Medicine. Center for Occupational and Environmental Health (COEH), University of California, Irvine, CA, USA., Garcia-Leon JA; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., Kitazawa M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Division of Occupational and Environmental Medicine, Department of Medicine. Center for Occupational and Environmental Health (COEH), University of California, Irvine, CA, USA., Shahnawaz M; The Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Matheos DP; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Ma X; Department of Developmental and Cell Biology, University of California, Irvine, CA, USA., Da Cunha C; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Walls KC; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Ager RR; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA., Soto C; The Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Gutierrez A; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., Moreno-Gonzalez I; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Instituto de Investigacion Biomedica de Malaga-IBIMA, Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain.; The Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Mortazavi A; Department of Developmental and Cell Biology, University of California, Irvine, CA, USA., Tenner AJ; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.; Department of Molecular Biology and Biochemistry, University of California, Irvine, CA, USA., MacGregor GR; Department of Developmental and Cell Biology, University of California, Irvine, CA, USA., Wood M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Green KN; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA. kngreen@uci.edu.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA. kngreen@uci.edu., LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA. laferla@uci.edu.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA. laferla@uci.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Apr 23; Vol. 12 (1), pp. 2421. Date of Electronic Publication: 2021 Apr 23.

Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.

Autor: Trujillo-Estrada L; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Nguyen C; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., da Cunha C; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Cai L; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Forner S; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Martini AC; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Ager RR; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Prieto GA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Cotman CW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California.; Department of Neurology, University of California, Irvine, California., Baglietto-Vargas D; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California., LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California.

Publikováno v: Aging cell [Aging Cell] 2019 Jun; Vol. 18 (3), pp. e12919. Date of Electronic Publication: 2019 Feb 27.

Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice.

Autor: Baglietto-Vargas D; Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Chen Y; Department of Pediatrics, University of California, Irvine, California, USA., Suh D; Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Ager RR; Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Rodriguez-Ortiz CJ; Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Medeiros R; Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Myczek K; Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Green KN; Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA., Baram TZ; Department of Pediatrics, University of California, Irvine, California, USA.; Department of Anatomy/Neurobiology, University of California, Irvine, California, USA., LaFerla FM; Department of Neurobiology and Behavior and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.

Publikováno v: Journal of neurochemistry [J Neurochem] 2015 Sep; Vol. 134 (5), pp. 915-26. Date of Electronic Publication: 2015 Jul 14.

Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss.

Autor: Ager RR; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Davis JL; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California., Agazaryan A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California., Benavente F; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California., Poon WW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California., LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California., Blurton-Jones M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California.

Publikováno v: Hippocampus [Hippocampus] 2015 Jul; Vol. 25 (7), pp. 813-26. Date of Electronic Publication: 2015 Jan 08.