Výsledky vyhledávání - "Ageing and Degeneration"

CD44 impacts glomerular parietal epithelial cell changes in the aged mouse kidney

Autor: Diana G. Eng, Stuart J. Shankland, Keiju Hiromura, Hiroko Hamatani, Jeffrey W. Pippin

Publikováno v: Physiological Reports
Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)

CD44 contributes to the activation of glomerular parietal epithelial cells (PECs). Although CD44 expression is higher in PECs of healthy aged mice, the biological role of CD44 in PECs in this context remains unclear. Accordingly, young (4 months) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba6aece5d6d449066754a789c4d0fb3
http://europepmc.org/articles/PMC7322268

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The effect of age on cerebral blood flow responses during repeated and sustained stand to sit transitions

Autor: Petra Wollseiffen, Tom G. Bailey, Timo Klein, Christopher D. Askew, Stefan Schneider

Publikováno v: Physiological Reports, Vol 8, Iss 9, Pp n/a-n/a (2020)
Physiological Reports

Introduction Aging is associated with impaired cerebrovascular blood flow and function, attributed to reduced vasodilatory capacity of the cerebrovascular network. Older adults may also have an impaired relationship between changes in blood pressure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7a3afd5080ddb391985817619cd858
https://doaj.org/article/9c289123103148ec8211e2e726190dba

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Glucose‐induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs

Autor: Shali Chen, Saumik Biswas, Biao Feng, Subrata Chakrabarti, Niharika Nagrani, Jieting Liu, Yanhui Chu

Publikováno v: Physiological Reports
Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020)

Diabetic complications cause significant morbidity and mortality. Dysfunction of vascular endothelial cells (ECs), caused by oxidative stress, is a main mechanism of cellular damage. Oxidative stress accelerates EC senescence and DNA damage. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4df9de263086cea761982e5e3be9af6
https://doi.org/10.14814/phy2.14331

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Role of sodium‐dependent Pi transporter/Npt2c on Pi homeostasis in klotho knockout mice different properties between juvenile and adult stages

Autor: Hiroko Segawa, Ichiro Kaneko, Sumire Sasaki, Yuki Arima, Tomoka Hasegawa, Ai Hanazaki, Kayo Ikuta, Yuji Shiozaki, Shohei Sasaki, Ken-ichi Miyamoto, Sawako Tatsumi, Kazuya Tanifuji, Norio Amizuka, Megumi Koike

Publikováno v: Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020)
Physiological Reports

SLC34A3/NPT2c/NaPi‐2c/Npt2c is a growth‐related NaPi cotransporter that mediates the uptake of renal sodium‐dependent phosphate (Pi). Mutation of human NPT2c causes hereditary hypophosphatemic rickets with hypercalciuria. Mice with Npt2c knocko

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611049b38af5e0fdcbf9a3176e16ebf0
https://doaj.org/article/5c073f670fde43a4b70470221bc3277b

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A pilot study assessing reliability and age‐related differences in corticomuscular and intramuscular coherence in ankle dorsiflexors during walking

Autor: Gennaro, F., de Bruin, E. D.

Publikováno v: Physiological Reports, Vol 8, Iss 4, Pp n/a-n/a (2020)
Physiological Reports

Corticomuscular (CMC) and intramuscular (intraMC) coherence represent measures of corticospinal interaction. Both CMC and intraMC can be assessed during human locomotion tasks, for example, while walking. Corticospinal control of gait can deteriorate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a1539c65d5e2abf8e3d9ba3b95ed9027
https://doaj.org/article/8b13b4047942419cafd7c24e2dc164d3

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Habitual cigarette smoking attenuates shear‐mediated dilation in the brachial artery but not in the carotid artery in young adults

Autor: Kazunori Kato, Takuro Washio, Shingo Tsukamoto, Erika Iwamoto, Kazuya Suzuki, Shigehiko Ogoh

Publikováno v: Physiological Reports
Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020)

In the present study, we hypothesized that habitual cigarette smoking attenuates endothelial function in the cerebral circulation as well as that of the peripheral circulation in young adults. To test this hypothesis, we measured cerebrovascular and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b40565949b8e406b6130c77dd4c94e
http://europepmc.org/articles/PMC7023886

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Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines

Autor: Daniella Azulai, Abigail Goldberger, Zachary A. Graham, Christopher Cardozo, William A. Bauman, Joshua F. Yarrow, Christine F. Conover, Fan Ye

Publikováno v: Physiological Reports, Vol 8, Iss 3, Pp n/a-n/a (2020)
Physiological Reports

To determine whether muscle disuse after a spinal cord injury (SCI) produces elevated markers of cellular senescence and induces markers of the senescence‐associated secretory phenotypes (SASPs) in paralyzed skeletal muscle. Four‐month‐old male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0791711a8cdc736eb8980e481b7233b
https://doaj.org/article/3381b354e5b547e59c494fb0e86d9729

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Acquisition and maintenance of motor memory through specific motor practice over the long term as revealed by stretch reflex responses in older ballet dancers

Autor: Tetsuya Ogawa, GeeHee Kim, Hirofumi Sekiguchi, Kimitaka Nakazawa

Publikováno v: Physiological Reports, Vol 8, Iss 2, Pp n/a-n/a (2020)
Physiological Reports

The present study addressed whether motor memory acquired earlier in life through specific training can be maintained through later life with further training. To this end, the present study focused on the training effect of a specific ballet practic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c783d49fb2ea770201e71e1e67dc04
https://doaj.org/article/e43f5ca2dc0345e49000e799f0f7d66b

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Diaphragm muscle sarcopenia into very old age in mice

Autor: Heather M. Gransee, Wen Zhi Zhan, Pangdra Vang, Gary C. Sieck, Carlos B. Mantilla, Amrit K. Vasdev

Publikováno v: Physiological Reports
Physiological Reports, Vol 8, Iss 1, Pp n/a-n/a (2020)

Sarcopenia is the age‐related decline of skeletal muscle mass and function. Diaphragm muscle (DIAm) sarcopenia may contribute to respiratory complications, a common cause of morbidity and mortality in the elderly. From 6 to 24 months (mo) of age, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67ac60742a1c367061117b9777b5e23
https://doi.org/10.14814/phy2.14305

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Heterogeneous effect of aging on vasorelaxation responses in large and small arteries

Autor: Meredith J. Luttrell, Christopher R. Woodman, Michael P. Massett, Dylan Holly, H Kim, Song Yi Shin

Publikováno v: Physiological Reports
Physiological Reports, Vol 8, Iss 1, Pp n/a-n/a (2020)

Aging is associated with impaired vascular function characterized in part by attenuated vasorelaxation to acetylcholine (ACh) and sodium nitroprusside (SNP). Due to structural and functional differences between conduit and resistance arteries, the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2a41bcb1517e5b11116d744f8cca2f
https://doi.org/10.14814/phy2.14341

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