Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Agegnehu Gettie"'
Autor:
Nina Derby, Manjari Lal, Meropi Aravantinou, Larisa Kizima, Patrick Barnable, Aixa Rodriguez, Manshun Lai, Asa Wesenberg, Shweta Ugaonkar, Keith Levendosky, Olga Mizenina, Kyle Kleinbeck, Jeffrey D. Lifson, M. Melissa Peet, Zachary Lloyd, Michael Benson, Walid Heneine, Barry R O’Keefe, Melissa Robbiani, Elena Martinelli, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Natalia Teleshova, José A. Fernández-Romero, Thomas M. Zydowsky
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Safety and efficacy remain important challenges for non-antiretroviral-based microbicides. Here, Derby et al. show that a Griffithsin-Carrageenan fast dissolving vaginal insert provides on-demand protection against SHIV infections in macaques, paving
Externí odkaz:
https://doaj.org/article/8d4f42eeb266482fa22316c03e392e44
Autor:
Giulia Calenda, Ines Frank, Géraldine Arrode-Brusés, Amarendra Pegu, Keyun Wang, James Arthos, Claudia Cicala, Kenneth A Rogers, Lisa Shirreff, Brooke Grasperge, James L Blanchard, Stephanie Maldonado, Kevin Roberts, Agegnehu Gettie, Francois Villinger, Anthony S Fauci, John R Mascola, Elena Martinelli
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007776 (2019)
VRC01 protects macaques from vaginal SHIV infection after a single high-dose challenge. Infusion of a simianized anti-α4β7 mAb (Rh-α4β7) just prior to, and during repeated vaginal exposures to SIVmac251 partially protected macaques from vaginal S
Externí odkaz:
https://doaj.org/article/56f99e9871a14c77a113d5c201dca31e
A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation
Autor:
Qian Wang, Lihong Liu, Wuze Ren, Agegnehu Gettie, Hua Wang, Qingtai Liang, Xuanling Shi, David C. Montefiori, Tongqing Zhou, Linqi Zhang
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2593-2607.e5 (2019)
Summary: The HIV-1 envelope glycoprotein (Env) maintains a delicate balance between mediating viral entry and escaping antibody neutralization. Adaptation during transmission of neutralization-sensitive Envs with an “open” conformation remains po
Externí odkaz:
https://doaj.org/article/757562a180b44e8aa037647a996c4f5a
Autor:
Meropi Aravantinou, Olga Mizenina, Giulia Calenda, Jessica Kenney, Ines Frank, Jeffrey D. Lifson, Moriah Szpara, Lichen Jing, David M. Koelle, Natalia Teleshova, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Elena Martinelli, Nina Derby
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Herpes simplex virus 1 and 2 (HSV-1/2) similarly initiate infection in mucosal epithelia and establish lifelong neuronal latency. Anogenital HSV-2 infection augments the risk for sexual human immunodeficiency virus (HIV) transmission and is associate
Externí odkaz:
https://doaj.org/article/1f673356d51b44bbb4efd3d67140f2ad
Autor:
Géraldine Arrode-Brusés, Diana Goode, Kyle Kleinbeck, Jolanta Wilk, Ines Frank, Siddappa Byrareddy, James Arthos, Brooke Grasperge, James Blanchard, Thomas Zydowsky, Agegnehu Gettie, Elena Martinelli
Publikováno v:
PLoS Pathogens, Vol 12, Iss 7, p e1005781 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005720.].
Externí odkaz:
https://doaj.org/article/c204e395add544a2bcb0986d261e9c99
Autor:
Géraldine Arrode-Brusés, Diana Goode, Kyle Kleinbeck, Jolanta Wilk, Ines Frank, Siddappa Byrareddy, James Arthos, Brooke Grasperge, James Blanchard, Thomas Zydowsky, Agegnehu Gettie, Elena Martinelli
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005720 (2016)
Mucosal HIV-1 transmission is inefficient. However, certain viral and host characteristics may play a role in facilitating HIV acquisition and systemic expansion. Cells expressing high levels of integrin α4β7 have been implicated in favoring the tr
Externí odkaz:
https://doaj.org/article/0616339cd7514d40a07693258cae0171
Autor:
Guillermo Villegas, Giulia Calenda, Shweta Ugaonkar, Shimin Zhang, Larisa Kizima, Olga Mizenina, Agegnehu Gettie, James Blanchard, Michael L Cooney, Melissa Robbiani, José A Fernández-Romero, Thomas M Zydowsky, Natalia Teleshova
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159332 (2016)
Women need multipurpose prevention products (MPTs) that protect against sexually transmitted infections (STIs) and provide contraception. The Population Council has developed a prototype intravaginal ring (IVR) releasing the non-nucleoside reverse tr
Externí odkaz:
https://doaj.org/article/2c7ce7258bc743d49918758692207898
Autor:
Natalia Guerra-Pérez, Meropi Aravantinou, Filippo Veglia, Diana Goode, Rosaline Truong, Nina Derby, James Blanchard, Brooke Grasperge, Agegnehu Gettie, Melissa Robbiani, Elena Martinelli
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149491 (2016)
Prevalent HSV-2 infection increases the risk of HIV acquisition both in men and women even in asymptomatic subjects. Understanding the impact of HSV-2 on the mucosal microenvironment may help to identify determinants of susceptibility to HIV. Vaginal
Externí odkaz:
https://doaj.org/article/3346cfefab224f0fbd8ca3306f113b26
Autor:
Meropi Aravantinou, Ines Frank, Magnus Hallor, Rachel Singer, Hugo Tharinger, Jessica Kenney, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Andres Salazar, Michael Piatak, Jeffrey D Lifson, Melissa Robbiani, Nina Derby
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161730 (2016)
Myeloid dendritic cells (mDCs) contribute to both HIV pathogenesis and elicitation of antiviral immunity. Understanding how mDC responses to stimuli shape HIV infection outcomes will inform HIV prevention and treatment strategies. The long double-str
Externí odkaz:
https://doaj.org/article/4431bc835c684b81878ea77df9d8e4e0
Autor:
Diana Goode, Rosaline Truong, Guillermo Villegas, Giulia Calenda, Natalia Guerra-Perez, Michael Piatak, Jeffrey D Lifson, James Blanchard, Agegnehu Gettie, Melissa Robbiani, Elena Martinelli
Publikováno v:
PLoS Pathogens, Vol 10, Iss 12, p e1004567 (2014)
The availability of highly susceptible HIV target cells that can rapidly reach the mucosal lymphoid tissues may increase the chances of an otherwise rare transmission event to occur. Expression of α4β7 is required for trafficking of immune cells to
Externí odkaz:
https://doaj.org/article/61a983217bd64e148352e5468b30be3d