Prognostic value of insulin-like growth factor 1 and insulin-like growth factor binding protein 3 blood levels in breast cancer

Autor: Hendrika Boezen, M M de Jong, W.T.A. van der Graaf, Jelle Wesseling, Michael Schaapveld, Hermien Hartog

Publikováno v: Breast, 22, 1155-60
Breast, 22, 6, pp. 1155-60
The Breast, 22(6), 1155-1160. Churchill Livingstone

Item does not contain fulltext High circulating insulin-like growth factor 1 (IGF-1) levels are firmly established as a risk factor for developing breast cancer, especially estrogen positive tumors. The effect of circulating IGF-1 on prognosis once a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be362381e7119cc53ab7b4921d05b5a0
https://research.rug.nl/en/publications/513744ec-6cb0-4821-9680-5d97cc9b501d

Bevacizumab reduces tumor targeting of antiepidermal growth factor and anti-insulin-like growth factor 1 receptor antibodies

Autor: Heskamp, S., Boerman, O.C., Molkenboer-Kuenen, J.D.M., Oyen, W.J.G., Graaf, W.T.A. van der, Laarhoven, H.W.M. van

Publikováno v: International Journal of Cancer, 133, 2, pp. 307-314
International Journal of Cancer, 133, 307-314

Item does not contain fulltext Bevacizumab (antivascular endothelial growth factor [anti-VEGF]) and cetuximab (antiepidermal growth factor receptor [anti-EGFR]) are approved antibodies for treatment of cancer. However, in advanced colorectal cancer,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::453e7f92e604273f3cae1b28a01d6f83
https://hdl.handle.net/2066/118060

A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients

Autor: Erik A.C. Wiemer, Walter J. Loos, Jaap Verweij, Martin N Fransson, Alex Sparreboom, An K.L. Reyners, Lena E. Friberg, Ugo De Giorgi, Karel Eechoute, Ron H.J. Mathijssen, Gaia Schiavon, Floris A. de Jong, Winette T. A. van der Graaf

Publikováno v: Clinical Cancer Research, 18, 20, pp. 5780-5787
Clinical Cancer Research, 18, 5780-5787
Clinical Cancer Research, 18(20), 5780-5787. American Association for Cancer Research Inc.
Clinical Cancer Research, 18(20), 5780-5787. AMER ASSOC CANCER RESEARCH

Purpose: Imatinib minimal (trough) plasma concentrations after one month of treatment have shown a significant association with clinical benefit in patients with gastrointestinal stromal tumors (GIST). Considering that a retrospective pharmacokinetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786ed4dc25586d2d5c4be826badb3930
https://research.rug.nl/en/publications/3a305662-efaa-49e4-928a-39cebea8e0ae

‘Big’-Insulin-Like Growth Factor–II Signaling Is an Autocrine Survival Pathway in Gastrointestinal Stromal Tumors

Autor: Winette T. A. van der Graaf, Coby Meijer, Gert Jan Meersma, Ed Schuuring, Jaap van Doorn, Bart Rikhof, Steven de Jong, Albert J. H. Suurmeijer, Patricia J. T. A. Groenen

Publikováno v: American Journal of Pathology, 181, 303-12
American Journal of Pathology, 181, 1, pp. 303-12
American Journal of Pathology, 181(1), 303-312. ELSEVIER SCIENCE INC

Contains fulltext : 109924.pdf (Publisher’s version ) (Closed access) New treatment targets need to be identified in gastrointestinal stromal tumors (GISTs) to extend the treatment options for patients experiencing failure with small-molecule tyros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1669bc39b1fe3a784f5ad0d2433149e4
https://doi.org/10.1016/j.ajpath.2012.03.028

Building the bridge between rhabdomyosarcoma in children, adolescents and young adults: The road ahead

Autor: J. Carlijn van Gaal, Winette T. A. van der Graaf, Suzanne E. J. Kaal, Eveline S. J. M. de Bont, Yvonne M.H. Versleijen-Jonkers

Publikováno v: Critical Reviews in Oncology Hematology, 82, 3, pp. 259-79
Critical Reviews in Oncology Hematology, 82, 259-79

Rhabdomyosarcoma (RMS) is a rare type of soft tissue sarcoma that mainly affects children, but also occurs in adolescents and (young) adults (AYA). Despite dramatic survival improvements reported by international study groups in children over the pas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba939efcd8987ee24c145af64dd0368
https://doi.org/10.1016/j.critrevonc.2011.06.005