Biosynthetic proteins targeting the SARS-CoV-2 spike as anti-virals.

Autor: Stéphanie Thébault, Nathalie Lejal, Alexis Dogliani, Amélie Donchet, Agathe Urvoas, Marie Valerio-Lepiniec, Muriel Lavie, Cécile Baronti, Franck Touret, Bruno Da Costa, Clara Bourgon, Audrey Fraysse, Audrey Saint-Albin-Deliot, Jessica Morel, Bernard Klonjkowski, Xavier de Lamballerie, Jean Dubuisson, Alain Roussel, Philippe Minard, Sophie Le Poder, Nicolas Meunier, Bernard Delmas

Publikováno v: PLoS Pathogens, Vol 18, Iss 9, p e1010799 (2022)

The binding of the SARS-CoV-2 spike to angiotensin-converting enzyme 2 (ACE2) promotes virus entry into the cell. Targeting this interaction represents a promising strategy to generate antivirals. By screening a phage-display library of biosynthetic

Externí odkaz: https://doaj.org/article/d2a6cd32cafa48d3ae433b0ace8da4c0

Structural Analysis of the Hanks-Type Protein Kinase YabT From Bacillus subtilis Provides New Insights in its DNA-Dependent Activation

Autor: Lei Shi, Andrea Cavagnino, Jean-Luc Rabefiraisana, Noureddine Lazar, Inès Li de la Sierra-Gallay, Françoise Ochsenbein, Marie Valerio-Lepiniec, Agathe Urvoas, Philippe Minard, Ivan Mijakovic, Sylvie Nessler

Publikováno v: Frontiers in Microbiology, Vol 9 (2019)

YabT is a serine/threonine kinase of the Hanks family from Bacillus subtilis, which lacks the canonical extracellular signal receptor domain but is anchored to the membrane through a C-terminal transmembrane helix. A previous study demonstrated that

Externí odkaz: https://doaj.org/article/58e56ba82247410390b8d7f6509ae6c5

Binding of a Soluble meso-Tetraarylporphyrin to Human Galectin-7 Induces Oligomerization and Modulates Its Pro-Apoptotic Activity

Autor: Philippe Egesborg, Clara Lafortune, Yves St-Pierre, Nicolas Doucet, Jean-Pierre Mahy, Agathe Urvoas, David Chatenet, Yossef López de los Santos, David N. Bernard, Matthew J. Cuneo, Rémy Ricoux, Myriam Létourneau

Publikováno v: Biochemistry
Biochemistry, 2020, ⟨10.1021/acs.biochem.0c00736⟩

The selective targeting of protein-protein interactions remains a significant determinant for the proper modulation and regulation of cell apoptosis. Prototypic galectins such as human galectin-7 (GAL-7) are characterized by their ability to form hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d645ea5f73d83e3cd8a494148cccda9f
https://doi.org/10.1021/acs.biochem.0c00736

Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors

Autor: Magali Aumont-Nicaise, Liza Ammar Khodja, Magali Noiray, Agathe Urvoas, Philippe Minard, Valérie Campanacci, Benoît Gigant, Sylvie Lachkar, Patrick A. Curmi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119, pp.e2120098119. ⟨10.1073/pnas.2120098119⟩

Microtubule dynamics is regulated by various cellular proteins and perturbed by small molecule compounds. To what extent the mechanism of the former resembles that of the latter is an open question. We report here structures of tubulin bound to the P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba55121e6c5d24b8c287ba88c2d045d
https://hal.archives-ouvertes.fr/hal-03431978

Binding of a Soluble

Autor: Yossef, López de Los Santos, David N, Bernard, Philippe, Egesborg, Myriam, Létourneau, Clara, Lafortune, Matthew J, Cuneo, Agathe, Urvoas, David, Chatenet, Jean-Pierre, Mahy, Yves, St-Pierre, Rémy, Ricoux, Nicolas, Doucet

Publikováno v: Biochemistry

The selective targeting of protein-protein interactions remains a significant determinant for the proper modulation and regulation of cell apoptosis. Prototypic galectins such as human galectin-7 (GAL-7) are characterized by their ability to form hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f78fdd1c99ef3b1798c08b4f5dc84f5
https://pubmed.ncbi.nlm.nih.gov/33231438