Synthesis of pyrido[2,1-a]isoquinolin-4-ones and oxazino[2,3-a]isoquinolin-4-ones: New inhibitors of mitochondrial respiratory chain

Autor: Maria-Jesus Sanz, Agathe Boulangé, Laura Moreno, Nuria Cabedo, Javier Párraga, Stéphane Leleu, Abraham Galán, Diego Cortes, Xavier Franck

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2013, 69, pp.69-76. ⟨10.1016/j.ejmech.2013.08.013⟩

International audience; Benzo[a]quinolizine is an important heterocyclic framework that can be found in numerous bioactive compounds. The general scheme for the synthesis of these compounds was based on the preparation of the appropriate dihydroisoqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4a6e6c5544fe45648d420e259ec314
https://doi.org/10.1016/j.ejmech.2013.08.013

Characterization of fluorescent synthetic epicocconone-based dye through advanced light microscopies for live cell imaging applications

Autor: Alexis Lebon, Stéphane Leleu, Ludovic Galas, Xavier Franck, Agathe Boulangé, Magalie Bénard, Thibault Gallavardin, Caroline Perraudeau, Damien Schapman

Publikováno v: Dyes and Pigments
Dyes and Pigments, Elsevier, 2017, 141, pp.394-405. ⟨10.1016/j.dyepig.2017.02.034⟩

International audience; Identification of new fluorescent biomarkers is a key issue to decipher mechanisms in living cells. Isolated from the fungus Epicoccum nigrum, natural epicocconone (NE) establishes a covalent and reversible link with primary a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9a150a7b9b2fb15eb3025cd0632a08
https://hal-normandie-univ.archives-ouvertes.fr/hal-02046308

Metal-Free SN2′ Decarboxylative Rearrangement of β-Keto Esters

Autor: Stéphane Leleu, Xavier Franck, Vincent Bizet, Marie-Claire Lasne, Agathe Boulangé, Jérôme Baudoux, Jacques Rouden, Valerie Lefebvre

Publikováno v: European Journal of Organic Chemistry
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2011, 2011 (22), pp.4170-4175. ⟨10.1002/ejoc.201100120⟩
European Journal of Organic Chemistry (22), 4170-4175. (2011)

International audience; Treatment of 2-methoxycarbonyl- (or 3-cyano-)allyl acetoacetates with a tertiary amine or triphenylphosphane afforded α-methylene γ-substituted δ-keto esters (or nitrile) in satisfactory yields. Various bases and nucleophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c769535f8b2919ef2b90a9116708e77b
https://doi.org/10.1002/ejoc.201100120

Synthesis and antibacterial activities of cadiolides A, B and C and analogues

Autor: Xavier Franck, Abraham Galán, Javier Párraga, Diego Cortes, Maria-Jesus Sanz, Agathe Boulangé, Stéphane Leleu, Nuria Cabedo

Publikováno v: Boulangé, Agathe Párraga Vidal, Javier Galán Morant, Abraham Cabedo Escrig, Nuria Leleu, Stéphane Sanz Ferrando, María Jesús Cortés Martínez, Diego M. Franck, Xavier 2015 Synthesis and antibacterial activities of cadiolides A, B and C and analogues Bioorganic & Medicinal Chemistry 23 13 3618 3628
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2015, 23 (13), pp.3618-3628. ⟨10.1016/j.bmc.2015.04.010⟩
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname

International audience; The one-pot multicomponent synthesis of natural butenolides named cadiolides A, B, C and analogues has been realized. The antibacterial structure activity relationship shows that the presence of phenolic hydroxyl groups and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e253214f3cc69d352e98788a73fb68
http://hdl.handle.net/10550/63166

Design and Synthesis of Epicocconone Analogues with Improved Fluorescence Properties

Autor: Peter Karuso, Xavier Franck, Bertrand Naudin, Philippe A. Peixoto, Malcolm S. Ball, Thibault Alle, Pascal Cosette, Agathe Boulangé

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2014, 136 (43), pp.15248-15256. ⟨10.1021/ja506914p⟩

Epicocconone is a natural latent fluorophore that is widely used in biotechnology because of its large Stokes shift and lack of fluorescence in its unconjugated state. However, the low photostability and quantum yields of epicocconone have limited it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6930d7799949cbbe1a93776a6adf26d
https://hal.archives-ouvertes.fr/hal-01150295