Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Agatha Sheerin"'
Autor:
Gary L, Griffiths, Chien-Hsing, Chang, William J, McBride, Edmund A, Rossi, Agatha, Sheerin, German R, Tejada, Habibe, Karacay, Robert M, Sharkey, Ivan D, Horak, Hans J, Hansen, David M, Goldenberg
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 45(1)
The aim of this work was to develop reagents and methods potentially useful in PET, using (68)Ga in a 2-step pretargeting protocol.We prepared bispecific antibodies (bsAbs) for disease-specific targeting of carcinoembryonic antigen-positive cells and
Autor:
Fatma Tat, Agatha Sheerin, David M. Goldenberg, Anju Nair, Maria Zalath, Thomas M. Cardillo, Sung-Ju Moon, Robert M. Sharkey, Serengulam V. Govindan
Publikováno v:
Cancer Research. 70:2438-2438
Antibody (MAb) conjugates of the potent topoisomerase I inhibitor, SN-38, have been previously shown by our groups to be efficacious in the targeted therapies of human cancer xenografts in nude mice. The conjugates have since been redesigned with a n
Abstract 2439: Cross-linker evaluation in the design of antibody-SN-38 conjugates for cancer therapy
Autor:
Serengulam V. Govindan, Roberto Arrojo, Maria Zalath, Thomas M. Cardillo, David M. Goldenberg, Agatha Sheerin, Sung-Ju Moon, Fatma Tat
Publikováno v:
Cancer Research. 70:2439-2439
Antibody (MAb) conjugates of the potent topoisomerase I inhibitor, SN-38, prepared using the bifunctional derivative, ‘CL2-SN-38’ (maleimido-[x]-Phe-Lys-PABOCO-20-O-SN-38), were previously shown to produce significant and selective therapeutic ef
Autor:
Rhona Stein, Thomas M. Cardillo, Serengulam V. Govindan, Agatha Sheerin, Ivan Horak, Jennifer S. Pickett, Christopher Damoci, Hans J. Hansen, Gary L. Griffiths, Puja Sapra, David M. Goldenberg
Publikováno v:
Blood. 104:3287-3287
IMMU-110 is a drug immunoconjugate comprised of doxorubicin (DOX) conjugated to the humanized anti-CD74 monoclonal antibody (mAb), hLL1, at a DOX:mAb (mol/mol) ratio of 8:1. CD74 is a rapidly internalizing type-II transmembrane chaperone molecule ass