Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Agata Villiger-Oberbek"'
Autor:
Su Chul Jang, Kyriakos D. Economides, Raymond J. Moniz, Chang Ling Sia, Nuruddeen Lewis, Christine McCoy, Tong Zi, Kelvin Zhang, Rane A. Harrison, Joanne Lim, Joyoti Dey, Marc Grenley, Katherine Kirwin, Nikki L. Ross, Raymond Bourdeau, Agata Villiger-Oberbek, Scott Estes, Ke Xu, Jorge Sanchez-Salazar, Kevin Dooley, William K. Dahlberg, Douglas E. Williams, Sriram Sathyanarayanan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Su Chul Jang et al. develop exoSTING, consisting of an engineered extracellular vesicle loaded with a potent cyclic dinucleotide (CDN) agonist of the STING pathway. They find that exoSTING shows more than 100-fold increased potency in in vivo tumor m
Externí odkaz:
https://doaj.org/article/d6164d29cedd4b8db922002838b3e600
Autor:
Kevin Dooley, Nuruddeen D. Lewis, Raymond W. Bourdeau, Williams Douglas E, Christine McCoy, Kelvin Xi Zhang, Katherine Kirwin, Joyoti Dey, Marc Grenley, Jorge Sanchez-Salazar, Nikki L. Ross, Agata Villiger-Oberbek, Su Chul Jang, Sriram Sathyanarayanan, Tong Zi, Joanne Lim, Kyriakos D. Economides, Ke Xu, William K. Dahlberg, Raymond J. Moniz, Scott Estes, Rane A. Harrison, Chang Ling Sia
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical models. However, CDNs administered intratumorally also promote STING activation leading to direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b76e65940414bd13ef06ef91b2232ab
https://doi.org/10.1038/s42003-021-02004-5
https://doi.org/10.1038/s42003-021-02004-5
Autor:
Kevin Dooley, Ke Xu, Sonya Haupt, Nuruddeen Lewis, Rane Harrison, Shelly Martin, Christine McCoy, Chang Ling Sia, Su Chul Jang, Katherine Kirwin, Russell McConnell, Bryan Choi, Adam T. Boutin, Damian Houde, Jorge Sanchez-Salazar, Agata Villiger-Oberbek, Kyriakos D. Economides, John D. Kulman, Sriram Sathyanarayanan
Publikováno v:
Cancer Research. 79:2150-2150
Exosomes are natural and abundant nanoscale vesicles for intercellular communication, capable of transferring biological instructions between neighboring and distant cell types. Translational research efforts have focused on exploiting this communica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa051548a3b3b8768088d7d86550e003
https://doi.org/10.1158/1538-7445.am2019-2150
https://doi.org/10.1158/1538-7445.am2019-2150
Autor:
Kevin Dooley, Rane A. Harrison, Christine McCoy, Chang Ling Sia, Raymond J. Moniz, Damian Houde, Tong Zi, Scott Estes, Ke Xu, Nikki L. Ross, Raymond W. Bourdeau, Kyriakos D. Economides, Sriram Sathyanarayanan, Agata Villiger-Oberbek, Nuruddeen D. Lewis, Jorge Sanchez-Salazar, William K. Dahlberg, Su Chul Jang
Publikováno v:
Cancer Research. 79:944-944
Background: The Stimulator of Interferon Genes (STING) pathway is an attractive target in immuno-oncology. Selective activation of the STING pathway in antigen presenting cells (APCs) is essential for eliciting a potent and specific anti-tumor immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d1f76b93374d5c3017f3be63b876236
https://doi.org/10.1158/1538-7445.am2019-944
https://doi.org/10.1158/1538-7445.am2019-944
Development and application of a high-throughput platform for perfusion-based cell culture processes
Publikováno v:
Journal of biotechnology. 212
A high-throughput (HT) cell culture model has been established for the support of perfusion-based cell culture processes operating at high cell densities. To mimic perfusion, the developed platform takes advantage of shake tubes and operates them in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc73b75864ffa947238882c0409ddf18
https://pubmed.ncbi.nlm.nih.gov/26197419
https://pubmed.ncbi.nlm.nih.gov/26197419