Zobrazeno 1 - 10
of 391
pro vyhledávání: '"Agata Siwek"'
Autor:
Salim M. Bastaki, Yousef M. Abdulrazzaq, Marwan Abdelrahim Zidan, Mohamed Shafiullah, Saif Ghdayer Alaryani, Fatima Awad Alnuaimi, Ernest Adeghate, Sahar Mohsin, Amal Akour, Agata Siwek, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Introduction: Brain histamine is considered an endogenous anticonvulsant and histamine H1 receptor. H1R antagonists have, in earlier studies, been found to induce convulsions. Moreover, research during the last two decades has provided more informati
Externí odkaz:
https://doaj.org/article/b7cfbbe239ca48f5bab4c712ebf9b4e0
Autor:
Dominik Straszak, Sylwia Woźniak, Agata Siwek, Monika Głuch-Lutwin, Marcin Kołaczkowski, Aldona Pietrzak, Bartłomiej Drop, Dariusz Matosiuk
Publikováno v:
Molecules, Vol 29, Iss 3, p 571 (2024)
μ-opioid receptor ligands such as morphine and fentanyl are the most known and potent painkillers. However, the severe side effects seen with their use significantly limit their widespread use. The continuous broadening of knowledge about the proper
Externí odkaz:
https://doaj.org/article/320eb04a4c514654807a191ca7115d2e
Autor:
Michał Załuski, Tadeusz Karcz, Anna Drabczyńska, Christin Vielmuth, Agnieszka Olejarz-Maciej, Monika Głuch-Lutwin, Barbara Mordyl, Agata Siwek, Grzegorz Satała, Christa E. Müller, Katarzyna Kieć-Kononowicz
Publikováno v:
Biomolecules, Vol 13, Iss 7, p 1079 (2023)
Multitarget drugs based on a hybrid dopamine–xanthine core were designed as potential drug candidates for the treatment of neurodegenerative diseases. Monoamine oxidase B (MAO-B) inhibitors with significant ancillary A2A adenosine receptor (A2AAR)
Externí odkaz:
https://doaj.org/article/a763a392789d4e87855485b3273ec76a
Autor:
Elżbieta Żmudzka, Klaudia Lustyk, Kinga Sałaciak, Agata Siwek, Jolanta Jaśkowska, Marcin Kołaczkowski, Jacek Sapa, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 399 (2023)
Memory impairments constitute a significant problem worldwide, and the COVID-19 pandemic dramatically increased the prevalence of cognitive deficits. Patients with cognitive deficits, specifically memory disturbances, have underlying comorbid conditi
Externí odkaz:
https://doaj.org/article/14281d0bf07a4c3fa2b1e60717b985a3
Autor:
Klaudia Lustyk, Kinga Sałaciak, Agata Siwek, Barbara Filipek, Jacek Sapa, Henryk Marona, Dorota Żelaszczyk, Karolina Pytka
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1256 (2022)
Arrhythmia, an irregular heartbeat, might be a life-threatening condition but also a risk factor for stroke or worsen the prognosis after myocardial infarction. The limited efficacy and proarrhythmic potential of the available drugs require searching
Externí odkaz:
https://doaj.org/article/4e067cc7310447c48c9235658364a46b
Autor:
Dorota Łażewska, Agata Siwek, Agnieszka Olejarz-Maciej, Agata Doroz-Płonka, Anna Wiktorowska-Owczarek, Marta Jóźwiak-Bębenista, David Reiner-Link, Annika Frank, Wioletta Sromek-Trzaskowska, Ewelina Honkisz-Orzechowska, Ewelina Królicka, Holger Stark, Marek Wieczorek, Waldemar Wagner, Katarzyna Kieć-Kononowicz, Anna Stasiak
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2187 (2022)
The clinical symptoms of Parkinson’s disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H3 receptor (H3R) and MAO B can increase DA levels in the brain. A series o
Externí odkaz:
https://doaj.org/article/9d182e4dcb5d4290bc05ad6a476c576a
Autor:
Dominik Straszak, Agata Siwek, Monika Głuch-Lutwin, Barbara Mordyl, Marcin Kołaczkowski, Aldona Pietrzak, Mansur Rahnama-Hezavah, Bartłomiej Drop, Dariusz Matosiuk
Publikováno v:
Molecules, Vol 27, Iss 9, p 2930 (2022)
The μ-opioid receptors belong to the family of G protein-coupled receptors (GPCRs), and their activation triggers a cascade of intracellular relays with the final effect of analgesia. Classical agonists of this receptor, such as morphine, are the ma
Externí odkaz:
https://doaj.org/article/0b660b25dfb14eb68e57adfc02e29837
Autor:
Monika Marcinkowska, Nikola Fajkis-Zajączkowska, Katarzyna Szafrańska, Jakub Jończyk, Agata Siwek, Barbara Mordyl, Tadeusz Karcz, Gniewomir Latacz, Marcin Kolaczkowski
Publikováno v:
ACS Chemical Neuroscience. 14:1166-1180
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ca36348eaf671ba227b3878442b92a2
https://doi.org/10.1021/acschemneuro.2c00800
https://doi.org/10.1021/acschemneuro.2c00800
Autor:
Monika Marcinkowska, Magdalena Kotańska, Agnieszka Zagórska, Joanna Śniecikowska, Monika Kubacka, Agata Siwek, Adam Bucki, Maciej Pawłowski, Marek Bednarski, Jacek Sapa, Małgorzata Starek, Monika Dąbrowska, Marcin Kołaczkowski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 536-545 (2018)
Despite the substantial clinical success of aspirin and clopidogrel in secondary prevention of ischemic stroke, up to 40% of patients remain resistant to the available antiplatelet treatment. Therefore, there is an urgent clinical need to develop nov
Externí odkaz:
https://doaj.org/article/ca47822105e94d8aa84ccd74b1b779d4
Autor:
Katarzyna Kucwaj-Brysz, Anna Dela, Sabina Podlewska, Marek Bednarski, Agata Siwek, Grzegorz Satała, Kinga Czarnota, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz
Publikováno v:
Molecules, Vol 26, Iss 22, p 7025 (2021)
Several studies confirmed the reciprocal interactions between adrenergic and serotoninergic systems and the influence of these phenomena on the pathogenesis of anxiety. Hence, searching for chemical agents with a multifunctional pharmacodynamic profi
Externí odkaz:
https://doaj.org/article/c378d5c166f349a6af1c3d5be2fa4bf7