The BCL-2 pathway preserves mammalian genome integrity by eliminating recombination-defective oocytes

Autor: Elias ElInati, Agata P. Zielinska, Afshan McCarthy, Nada Kubikova, Valdone Maciulyte, Shantha Mahadevaiah, Mahesh N. Sangrithi, Obah Ojarikre, Dagan Wells, Kathy K. Niakan, Melina Schuh, James M. A. Turner

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

If left unrepaired, meiotic DSBs are toxic to mammalian cells, thus oocytes in which DSBs persist are eliminated by the DNA-damage checkpoint. Here the authors provide insights into the roles of PUMA, NOXA and BAX during DNA damage checkpoint that el

Externí odkaz: https://doaj.org/article/c2bf829fec2b403580972f4e566da03c

Remote multimodality monitoring of maternal physiology from the first trimester to postpartum period: study results

Autor: Agata P. Zielinska, Edward Mullins, Elena Magni, Giulia Zamagni, Hana Kleprlikova, Olive Adams, Tamara Stampalija, Lorenzo Monasta, Christoph Lees

Publikováno v: Journal of Hypertension. 40:2280-2291

OBJECTIVES: Current antenatal care largely relies on widely spaced appointments, hence only a fraction of the pregnancy period is subject to monitoring. Continuous monitoring of physiological parameters could represent a paradigm shift in obstetric c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc721e57435e0782d36813f4a105ba0
https://doi.org/10.1097/hjh.0000000000003260

The feasibility of multimodality remote monitoring of maternal physiology during pregnancy

Autor: Agata P. Zielinska, Edward Mullins, Christoph Lees

Objectives: Gestational hypertension affects 10% of pregnancies, may occur without warning and has wide ranging effects on maternal, fetal and infant health. Antenatal care largely relies on in-person appointments, hence only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55a31d9d584963f4dcc537be894f2fc
https://lirias.kuleuven.be/handle/20.500.12942/700605

Chromosome Errors in Human Eggs Shape Natural Fertility Over Reproductive Life Span

Autor: Claus Andersen, Anne Mette Bay Bjørn, Agata P. Zielinska, Robert Blanshard, Lotte Berdiin Colmorn, Deborah M. Taylor, Geraldine M. Hartshorne, Joanna Liss, Louise Newnham, Eva Hoffmann, Marie Louise Grøndahl, Junping Cheng, Dmitry Nikiforov, Ivan Vogel, Jennifer R. Gruhn, Stine Gry Kristensen, Martyn Blayney, Danilo Cimadomo, Andrew Chi-Ho Chan, Vallari Shukla, Rajiv C. McCoy, Melina Schuh, Catello Scarica, Marta Krapchev, Antonio Capalbo, Krzysztof Lukaszuk, Filippo Ubaldi, Erik Ernst, Kay Elder, Laura Rienzi

Publikováno v: Science
Gruhn, J R, Zielinska, A P, Shukla, V, Blanshard, R, Capalbo, A, Cimadomo, D, Nikiforov, D, Chan, A C H, Newnham, L J, Vogel, I, Scarica, C, Krapchev, M, Taylor, D, Kristensen, S G, Cheng, J, Ernst, E, Bjørn, A M B, Colmorn, L B, Blayney, M, Elder, K, Liss, J, Hartshorne, G, Grøndahl, M L, Rienzi, L, Ubaldi, F, McCoy, R, Lukaszuk, K, Andersen, C Y, Schuh, M & Hoffmann, E R 2019, ' Chromosome errors in human eggs shape natural fertility over reproductive life span ', Science, vol. 365, no. 6460, pp. 1466-1469 . https://doi.org/10.1126/science.aav7321

Understanding fertility in young and old Fertility in humans follows a U-curve, with low rates in both teenagers and women of advancing maternal age (mid-30s and above). Gruhn et al. found that this distinct shape originates from chromosomal errors i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9297c56d67f4d9699fa8595e6e3463
https://doi.org/10.1097/ogx.0000000000000817

Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs

Autor: Rüdiger Moltrecht, K. Bianka Seres, Jennifer R. Gruhn, Heike Eckel, Eva Hoffmann, Martyn Blayney, Kay Elder, Ann-Sophie Frombach, Eirini Bellou, Ninadini Sharma, Melina Schuh, Agata P. Zielinska

Publikováno v: Zielinska, A P, Bellou, E, Sharma, N, Frombach, A S, Seres, K B, Gruhn, J R, Blayney, M, Eckel, H, Moltrecht, R, Elder, K, Hoffmann, E R & Schuh, M 2019, ' Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs ', Current Biology, vol. 29, no. 22, pp. 3749-3765.e7 . https://doi.org/10.1016/j.cub.2019.09.006
Current Biology

Summary Chromosome segregation errors during female meiosis are a leading cause of pregnancy loss and human infertility. The segregation of chromosomes is driven by interactions between spindle microtubules and kinetochores. Kinetochores in mammalian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9055afc4792c8972c4453a080625341
https://curis.ku.dk/portal/da/publications/meiotic-kinetochores-fragment-into-multiple-lobes-upon-cohesin-loss-in-aging-eggs(db65c38b-cfb3-4c93-933b-bcee29fc0e69).html