Systematic review of randomised controlled trials on interventions aimed at promoting colorectal cancer screening amongst ethnic minorities

Autor: Siti Nadiah Binte Abdul Latip, Si Emma Chen, Yu Ri Im, Agata P. Zielinska, Nikhil Pawa

Publikováno v: Ethnicity & Health. :1-35

Significant disparities exist between different ethnic groups when it comes to participation in colorectal cancer (CRC) screening programmes. A variety of interventions have been proposed to improve participation rates of ethnic minorities for CRC sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f2cfea930da8d98b90ef0dfaeef5fe
https://doi.org/10.1080/13557858.2022.2139815

Changing Student Perception of an Online Integrated Structured Clinical Examination During the COVID-19 Pandemic

Autor: Timothy Woo, Chunhei Li, Anastasia Donnir, Agata P Zielinska, Anthony Anthony, Sashiananthan Ganesananthan, Ankur Khajuria

Publikováno v: Advances in Medical Education and Practice, Vol Volume 12, Pp 887-894 (2021)
Advances in Medical Education and Practice

Sashiananthan Ganesananthan,1 Chunhei Li,1 Anastasia Donnir,1 Anthony Anthony,2 Timothy Woo,1 Agata P Zielinska,3 Ankur Khajuria4,5 1Cardiff University School of Medicine, Cardiff, UK; 2University Hospital Wales, NHS Wales, Cardiff, UK; 3Imperial Col

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4364e3961cab6a9e5c512c64c1d3fa0f
https://doi.org/10.2147/amep.s325364

Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

Autor: Agata P Zielinska, Zuzana Holubcova, Martyn Blayney, Kay Elder, Melina Schuh

Publikováno v: eLife, Vol 4 (2015)

Aneuploidy in human eggs is the leading cause of pregnancy loss and Down’s syndrome. Aneuploid eggs result from chromosome segregation errors when an egg develops from a progenitor cell, called an oocyte. The mechanisms that lead to an increase in

Externí odkaz: https://doaj.org/article/bc8855d3282043fc9d20e08469feeac2

Chromosome Errors in Human Eggs Shape Natural Fertility Over Reproductive Life Span

Autor: Claus Andersen, Anne Mette Bay Bjørn, Agata P. Zielinska, Robert Blanshard, Lotte Berdiin Colmorn, Deborah M. Taylor, Geraldine M. Hartshorne, Joanna Liss, Louise Newnham, Eva Hoffmann, Marie Louise Grøndahl, Junping Cheng, Dmitry Nikiforov, Ivan Vogel, Jennifer R. Gruhn, Stine Gry Kristensen, Martyn Blayney, Danilo Cimadomo, Andrew Chi-Ho Chan, Vallari Shukla, Rajiv C. McCoy, Melina Schuh, Catello Scarica, Marta Krapchev, Antonio Capalbo, Krzysztof Lukaszuk, Filippo Ubaldi, Erik Ernst, Kay Elder, Laura Rienzi

Publikováno v: Science
Gruhn, J R, Zielinska, A P, Shukla, V, Blanshard, R, Capalbo, A, Cimadomo, D, Nikiforov, D, Chan, A C H, Newnham, L J, Vogel, I, Scarica, C, Krapchev, M, Taylor, D, Kristensen, S G, Cheng, J, Ernst, E, Bjørn, A M B, Colmorn, L B, Blayney, M, Elder, K, Liss, J, Hartshorne, G, Grøndahl, M L, Rienzi, L, Ubaldi, F, McCoy, R, Lukaszuk, K, Andersen, C Y, Schuh, M & Hoffmann, E R 2019, ' Chromosome errors in human eggs shape natural fertility over reproductive life span ', Science, vol. 365, no. 6460, pp. 1466-1469 . https://doi.org/10.1126/science.aav7321

Understanding fertility in young and old Fertility in humans follows a U-curve, with low rates in both teenagers and women of advancing maternal age (mid-30s and above). Gruhn et al. found that this distinct shape originates from chromosomal errors i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9297c56d67f4d9699fa8595e6e3463
https://doi.org/10.1097/ogx.0000000000000817

Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs

Autor: Rüdiger Moltrecht, K. Bianka Seres, Jennifer R. Gruhn, Heike Eckel, Eva Hoffmann, Martyn Blayney, Kay Elder, Ann-Sophie Frombach, Eirini Bellou, Ninadini Sharma, Melina Schuh, Agata P. Zielinska

Publikováno v: Zielinska, A P, Bellou, E, Sharma, N, Frombach, A S, Seres, K B, Gruhn, J R, Blayney, M, Eckel, H, Moltrecht, R, Elder, K, Hoffmann, E R & Schuh, M 2019, ' Meiotic Kinetochores Fragment into Multiple Lobes upon Cohesin Loss in Aging Eggs ', Current Biology, vol. 29, no. 22, pp. 3749-3765.e7 . https://doi.org/10.1016/j.cub.2019.09.006
Current Biology

Summary Chromosome segregation errors during female meiosis are a leading cause of pregnancy loss and human infertility. The segregation of chromosomes is driven by interactions between spindle microtubules and kinetochores. Kinetochores in mammalian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9055afc4792c8972c4453a080625341
https://curis.ku.dk/portal/da/publications/meiotic-kinetochores-fragment-into-multiple-lobes-upon-cohesin-loss-in-aging-eggs(db65c38b-cfb3-4c93-933b-bcee29fc0e69).html