Výsledky vyhledávání - "Agata Naworyta"

Expanding the Catalytic Triad in Epoxide Hydrolases and Related Enzymes

Autor: Paul Bauer, Mikael Widersten, Agata Naworyta, Åsa Janfalk Carlsson, Sherry L. Mowbray, Fernanda Duarte, Shina Caroline Lynn Kamerlin, Beat Anton Amrein

Publikováno v: ACS Catalysis

Potato epoxide hydrolase 1 exhibits rich enantio- and regioselectivity in the hydrolysis of a broad range of substrates. The enzyme can be engineered to increase the yield of optically pure products as a result of changes in both enantio- and regiose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9d4237b8b67195e335e42ca5caa040
https://doi.org/10.1021/acscatal.5b01639

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Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi shed light on the determinants of sugar specificity in the structural family

Autor: Agata Naworyta, Sherry L. Mowbray, Juan José Cazzulo, Ana Laura Stern

Publikováno v: FEBS Journal. 278:793-808

Ribose-5-phosphate isomerase (Rpi; EC 5.3.1.6) is a key activity of the pentose phosphate pathway. Two unrelated types of sequence/structure possess this activity: type A Rpi (present in most organisms) and type B Rpi (RpiB) (in some bacteria and par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::103ca3261c29a5e3121fa37ac7e922f2
https://doi.org/10.1111/j.1742-4658.2010.07999.x

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Optimization and Evaluation of 5-Styryl-Oxathiazol-2-one Mycobacterium tuberculosis Proteasome Inhibitors as Potential Antitubercular Agents

Autor: Mai A. Bailey, Francesco Russo, Anders Sokolowski, Mats Larhed, Linda Åkerbladh, Anders Karlén, Ian Henderson, Sherry L. Mowbray, Torey Alling, Megan Files, Tanya Parish, Johan Gising, Agata Naworyta, Annette K. Roos

Publikováno v: ChemistryOpen

This is the first report of 5-styryl-oxathiazol-2-ones as inhibitors of the Mycobacterium tuberculosis (Mtb) proteasome. As part of the study, the structure–activity relationship of oxathiazolones as Mtb proteasome inhibitors has been investigated.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230a04efb31ff7d4ff01f919ff96ebd9
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258781

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Directed Evolution of an Enantioselective Epoxide Hydrolase : Uncovering the Source of Enantioselectivity at Each Evolutionary Stage

Autor: Alain Robert Archelas, Li-Wen Wang, Michael Arand, Joaquin Sanchis, Manfred T. Reetz, Anne Lise Bottalla, Marco Bocola, Sherry L. Mowbray, Jinyu Zou, Annette Cronin, Agata Naworyta

Directed evolution of enzymes as enantioselective catalysts in organic chemistry is an alternative to traditional asymmetric catalysis using chiral transition-metal complexes or organocatalysts, the different approaches often being complementary. Mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cebaff9a92918936ce0b1bbe1a52fcd
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-130672

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Removal of distal protein–water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability

Autor: Agata Naworyta, Mikael Widersten, Ann Thomaeus, Sherry L. Mowbray

A putative proton wire in potato soluble epoxide hydrolase 1, StEH1, was identified and investigated by means of site-directed mutagenesis, steady-state kinetic measurements, temperature inactivation studies, and X-ray crystallography. The chain of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d98207ea54e6ba82ab977f23cd64347
https://europepmc.org/articles/PMC2442007/

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