Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Agata Levay"'
Autor:
Greta Garrido, Brett Schrand, Ailem Rabasa, Agata Levay, Francesca D’Eramo, Alexey Berezhnoy, Shrey Modi, Tal Gefen, Koen Marijt, Elien Doorduijn, Vikas Dudeja, Thorbald van Hall, Eli Gilboa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The anti-tumour immune response greatly depends on the number of tumour neoantigens. Here the authors show in mouse models that a therapeutic strategy aimed at increasing the number of neoantigens via downregulating TAP, an antigen processing associa
Externí odkaz:
https://doaj.org/article/9412b6e3bd1140079d62c6a2a9c464d0
Autor:
Brett Schrand, Emily Clark, Agata Levay, Ailem Rabasa Capote, Olivier Martinez, Randall Brenneman, Iris Castro, Eli Gilboa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/5ad18fffa1fe4041b01e90a6279ca15a
Autor:
Brett Schrand, Emily Clark, Agata Levay, Ailem Rabasa Capote, Olivier Martinez, Randall Brenneman, Iris Castro, Eli Gilboa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Efficient tumor antigen uptake by dendritic cells is facilitated by antibody coating of tumor cells. Here, the authors develop an approach based on hapten vaccination and hapten/tumor targeting ligand conjugates that potentiate anti-tumor immunity by
Externí odkaz:
https://doaj.org/article/2b3fb79e93c34cee87312bf77ce68f7e
Autor:
Eli Gilboa, Thorbald van Hall, Vikas Dudeja, W. Martin Kast, Marcin Kortylewski, Deukwoo Kwon, Zhuoran Zhang, Koen A. Marijt, Francesca D'Eramo, Diane M. Da Silva, Anthony Ferrantella, Ailem Rabasa, Agata Levay, Brett Schrand, Greta Garrido
Supplementary Figures and Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4758aad3bc5429ecd5a479e1fbe4f7
https://doi.org/10.1158/2326-6066.22544020.v1
https://doi.org/10.1158/2326-6066.22544020.v1
Autor:
Eli Gilboa, Thorbald van Hall, Vikas Dudeja, W. Martin Kast, Marcin Kortylewski, Deukwoo Kwon, Zhuoran Zhang, Koen A. Marijt, Francesca D'Eramo, Diane M. Da Silva, Anthony Ferrantella, Ailem Rabasa, Agata Levay, Brett Schrand, Greta Garrido
Vaccination of patients against neoantigens expressed in concurrent tumors, recurrent tumors, or tumors developing in individuals at risk of cancer is posing major challenges in terms of which antigens to target and is limited to patients expressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3418e2867451795179a87a948445be83
https://doi.org/10.1158/2326-6066.c.6550510.v1
https://doi.org/10.1158/2326-6066.c.6550510.v1
Autor:
Eli Gilboa, Amy B. Heimberger, Shouhao Zhou, Ganesh Rao, Ling-Yuan Kong, Agata Levay, Anthony Williams, Randall Brenneman, Alexey Berezhnoy, Brett Schrand
PDF file - 87K, Supplementary Figure 1. Sequence and secondary structure ofVEGF-4-1BB and OPN-4-1BB aptamer conjugates. Supplementary Figure 2. Biodistribution of VEGF-4-1BB aptamer conjugates. Supplementary Figure 3. OPN-targeted costimulation inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311b6d046b187a28e00965a8c730640b
https://doi.org/10.1158/2326-6066.22537915
https://doi.org/10.1158/2326-6066.22537915
Autor:
Eli Gilboa, Amy B. Heimberger, Shouhao Zhou, Ganesh Rao, Ling-Yuan Kong, Agata Levay, Anthony Williams, Randall Brenneman, Alexey Berezhnoy, Brett Schrand
Despite the recent successes of using immune modulatory Abs in patients with cancer, autoimmune pathologies resulting from the activation of self-reactive T cells preclude the dose escalations necessary to fully exploit their therapeutic potential. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4044f88817653e902eeb618941fae722
https://doi.org/10.1158/2326-6066.c.6548605.v1
https://doi.org/10.1158/2326-6066.c.6548605.v1
Autor:
Adrian Ishkanian, Eli Gilboa, Hideo Yagita, Oliver Umland, Randall Brenneman, Ana Paula Benaduce, Iris Castro, Shradha Patel, Agata Levay, Bhavna Verma, Brett Schrand
Biodistribution of VEGF-4-1BB conjugate. Survival assay in MCA induced fibrosarcoma model. Cytokine levels in treated animals. Tumor volume studies with combinatorial therapy in Balb/c model. Histology and morphology for toxicity profiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c05a6de36908ed88c3cd591e149d8c4
https://doi.org/10.1158/0008-5472.22416309
https://doi.org/10.1158/0008-5472.22416309
Autor:
Adrian Ishkanian, Eli Gilboa, Hideo Yagita, Oliver Umland, Randall Brenneman, Ana Paula Benaduce, Iris Castro, Shradha Patel, Agata Levay, Bhavna Verma, Brett Schrand
Radiotherapy can elicit systemic immune control of local tumors and distant nonirradiated tumor lesions, known as the abscopal effect. Although this effect is enhanced using checkpoint blockade or costimulatory antibodies, objective responses remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da5ff4be1bc4ee36f98b3de6d2049c7
https://doi.org/10.1158/0008-5472.c.6509520
https://doi.org/10.1158/0008-5472.c.6509520
Autor:
Ailem Rabasa Capote, Eli Gilboa, Agata Levay, Olivier Martinez, Randall Brenneman, Iris Castro, Emily S. Clark, Brett Schrand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
Nature Communications
Nature Communications
Uptake of tumor antigens by tumor-infiltrating dendritic cells is limiting step in the induction of tumor immunity, which can be mediated through Fc receptor (FcR) triggering by antibody-coated tumor cells. Here we describe an approach to potentiate