Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Agata Jurczyk"'
Autor:
Julius O. Nyalwidhe, Agata Jurczyk, Basanthi Satish, Sambra Redick, Natasha Qaisar, Melanie I. Trombly, Pranitha Vangala, Riccardo Racicot, Rita Bortell, David M. Harlan, Dale L. Greiner, Michael A. Brehm, Jerry L. Nadler, Jennifer P. Wang
Publikováno v:
Microorganisms, Vol 8, Iss 2, p 295 (2020)
Enteroviral infections are implicated in islet autoimmunity and type 1 diabetes (T1D) pathogenesis. Significant β-cell stress and damage occur with viral infection, leading to cells that are dysfunctional and vulnerable to destruction. Human stem ce
Externí odkaz:
https://doaj.org/article/1e949cec547b495a95f084103d562d02
Autor:
Frederick R Roberts, Clinton Hupple, Elaine Norowski, Nicole C Walsh, Natalia Przewozniak, Ken-Edwin Aryee, Filia M Van Dessel, Agata Jurczyk, David M Harlan, Dale L Greiner, Rita Bortell, Chaoxing Yang
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0178641 (2017)
Studies of human cadaveric pancreas specimens indicate that pancreas inflammation plays an important role in type 1 diabetes pathogenesis. Due to the inaccessibility of pancreas in living patients, imaging technology to visualize pancreas inflammatio
Externí odkaz:
https://doaj.org/article/dcdb65ec0f2844ffb919749025c32f45
Publikováno v:
Neuronal Signaling
Disrupted in Schizophrenia 1 (DISC1) participates in a wide variety of developmental processes of central neurons. It also serves critical roles that underlie cognitive functioning in adult central neurons. Here we summarize DISC1’s general propert
Autor:
Chaoxing Yang, Agata Jurczyk, Philip diIorio, Elaine Norowski, Michael A Brehm, Christian W Grant, Dennis L Guberski, Dale L Greiner, Rita Bortell
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78050 (2013)
Epidemiologic and clinical evidence suggests that virus infection plays an important role in human type 1 diabetes pathogenesis. We used the virus-inducible BioBreeding Diabetes Resistant (BBDR) rat to investigate the ability of sodium salicylate, a
Externí odkaz:
https://doaj.org/article/10866a00990e4432ba57fc70af044e2e
Publikováno v:
Current Opinion in Endocrinology & Diabetes and Obesity. 25:94-100
PURPOSE: Understanding the relationship between viral infections and the development of type 1 diabetes (T1D) are essential for T1D prevention. Virus-induced innate immune responses, specifically type I interferon (IFN-I) and the IFN gene signature,
Autor:
Agata Jurczyk, Steven C Pino, Bryan O'Sullivan-Murphy, Martha Addorio, Erich A Lidstone, Philip Diiorio, Kathryn L Lipson, Clive Standley, Kevin Fogarty, Lawrence Lifshitz, Fumihiko Urano, John P Mordes, Dale L Greiner, Aldo A Rossini, Rita Bortell
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11812 (2010)
The centrosome is important for microtubule organization and cell cycle progression in animal cells. Recently, mutations in the centrosomal protein, pericentrin, have been linked to human microcephalic osteodysplastic primordial dwarfism (MOPD II), a
Externí odkaz:
https://doaj.org/article/87eb60336d2e4579be48ca104bae968e
Autor:
Steven C Pino, Bryan O'Sullivan-Murphy, Erich A Lidstone, Chaoxing Yang, Kathryn L Lipson, Agata Jurczyk, Philip diIorio, Michael A Brehm, John P Mordes, Dale L Greiner, Aldo A Rossini, Rita Bortell
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5468 (2009)
Gimap5 (GTPase of the immunity-associated protein 5) has been linked to the regulation of T cell survival, and polymorphisms in the human GIMAP5 gene associate with autoimmune disorders. The BioBreeding diabetes-prone (BBDP) rat has a mutation in the
Externí odkaz:
https://doaj.org/article/b47c27fdea4649c3bca3dcc7d7cff892
Autor:
Ronald G. Gregg, Shunyan Mo, Sonia Ortiz-Miranda, Agata Jurczyk, Leah Hennings, Scott A. Shaffer, Dale L. Greiner, Alan Cheng, Rui Ji, Rita Bortell, Terry W. Fletcher, Ann R. Rittenhouse, Ken-Edwin Aryee
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 311:G903-G919
Knockout technology has proven useful for delineating functional roles of specific genes. Here we describe and provide an explanation for striking pathology that occurs in a subset of genetically engineered mice expressing a rat CaVβ2a transgene und
Autor:
Manuel Garber, Rita Bortell, David M. Blodgett, Alan G. Derr, Dale L. Greiner, Sambra D. Redick, Leonard D. Shultz, Agata Jurczyk, David M. Harlan, Alper Kucukural, Jennifer P. Wang, Linda Leehy, Ann R. Rittenhouse
Publikováno v:
The FASEB Journal
Human pancreatic islets engrafted into immunodeficient mice serve as an important model for in vivo human diabetes studies. Following engraftment, islet function can be monitored in vivo by measuring circulating glucose and human insulin; however, it
Autor:
Michael P. Czech, Laura V. Danai, Rita Bortell, Lorena Garcia Menendez, Marina T. DiStefano, Dae Young Jung, Jong Hun Kim, Jason K. Kim, Rachel J. Roth Flach, Mark J. S. Kelly, Agata Jurczyk, Rohit Sharma, Laura C. Alonso
Publikováno v:
The Journal of Biological Chemistry
Previous studies revealed a paradox whereby mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) acted as a negative regulator of insulin sensitivity in chronically obese mice, yet systemic deletion of Map4k4 did not improve glucose toler