Výsledky vyhledávání - "Agata Desantis"

Akademický článek

Utrophin up-regulation by an artificial transcription factor in transgenic mice.

Autor: Elisabetta Mattei, Nicoletta Corbi, Maria Grazia Di Certo, Georgios Strimpakos, Cinzia Severini, Annalisa Onori, Agata Desantis, Valentina Libri, Serena Buontempo, Aristide Floridi, Maurizio Fanciulli, Dilair Baban, Kay E Davies, Claudio Passananti

Publikováno v: PLoS ONE, Vol 2, Iss 8, p e774 (2007)

Duchenne Muscular Dystrophy (DMD) is a severe muscle degenerative disease, due to absence of dystrophin. There is currently no effective treatment for DMD. Our aim is to up-regulate the expression level of the dystrophin related gene utrophin in DMD,

Externí odkaz: https://doaj.org/article/048d05e732e0409cba8e9153bd4c3701

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Che‐1‐induced inhibition of mTOR pathway enables stress‐induced autophagy

Publikováno v: The EMBO Journal. 34:1214-1230

Mammalian target of rapamycin (mTOR) is a key protein kinase that regulates cell growth, metabolism, and autophagy to maintain cellular homeostasis. Its activity is inhibited by adverse conditions, including nutrient limitation, hypoxia, and DNA dama

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd4d37294285c8769301c4d7c0646ac
https://doi.org/10.15252/embj.201489920

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Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization

Autor: Aristide Floridi, Cesare Manetti, Matteo Pallocca, Valeria Catena, Luca Casadei, Francesca De Nicola, Maurizio Fanciulli, Mariacristina Valerio, Tiziana Bruno, Giovanni Blandino, Agata Desantis, Cristina Sorino, Simona Iezzi, Frauke Goeman

Publikováno v: Journal of Experimental & Clinical Cancer Research : CR

Background Solid tumours are less oxygenated than normal tissues. Consequently, cancer cells acquire to be adapted to a hypoxic environment. The poor oxygenation of solid tumours is also a major indicator of an adverse cancer prognosis and leads to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac53d23bb133d04fe656423eb595a91f
https://doi.org/10.1186/s13046-017-0497-1

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Che-1 Promotes Tumor Cell Survival by Sustaining Mutant p53 Transcription and Inhibiting DNA Damage Response Activation

Autor: Claudio Passananti, Agata Desantis, Simona Iezzi, Francesca La Rosa, Maurizio Fanciulli, Alfonso Bellacosa, Gianluca Bossi, Giovanni Blandino, Aristide Floridi, Annapaola Franchitto, Silvia Di Agostino, Sergio Galanti, Barbara Benassi, Cristina Sorino, Francesca De Nicola, Tiziana Bruno

Publikováno v: Cancer cell
18 (2010): 122–134. doi:10.1016/j.ccr.2010.05.027
info:cnr-pdr/source/autori:Bruno T; Desantis A; Bossi G; Di Agostino S; Sorino C; De Nicola F; Iezzi S; Franchitto A; Benassi B; Galanti S; La Rosa F; Floridi A; Bellacosa A; Passananti C; Blandino G; Fanciulli M./titolo:Che-1 promotes tumor cell survival by sustaining mutant p53 transcription and inhibiting DNA damage response activation/doi:10.1016%2Fj.ccr.2010.05.027/rivista:Cancer cell (Print)/anno:2010/pagina_da:122/pagina_a:134/intervallo_pagine:122–134/volume:18

Summary Che-1 is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3c334657b429e8ffb398d04110ed57

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NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death

Autor: Agata Desantis, Francesca De Nicola, Claudio Passananti, Maria Grazia Di Certo, Tiziana Bruno, Simona Iezzi, Maria Teresa Ciotti, Elisabetta Mattei, Maurizio Fanciulli, Aristide Floridi, Nicoletta Corbi

Publikováno v: Journal of Cell Science. 120:1852-1858

Neurotrophin receptor-interacting MAGE homolog (NRAGE) has been recently identified as a cell-death inducer, involved in molecular events driving cells through apoptotic networks during neuronal development. Recently, we have focused on the functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ea66932edaaa13f50814ff6110c73f
https://doi.org/10.1242/jcs.03454

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HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation

Autor: Cinzia Rinaldo, F De Nicola, Silvia Soddu, Maurizio Fanciulli, Maurizio De Crescenzi, Valeria Catena, Aristide Floridi, Claudio Passananti, Tommaso Bruno, Cristina Sorino, Serena Camerini, Simona Iezzi, Agata Desantis

Publikováno v: Cell Death & Disease
Cell death and disease 5 (2014). doi:10.1038/cddis.2014.381
info:cnr-pdr/source/autori:De Nicola, F.; Catena, V.; Rinaldo, C.; Bruno, T.; Iezzi, S.; Sorino, C.; Desantis, A.; Camerini, S.; Crescenzi, M.; Floridi, A.; Passananti, C.; Soddu, S.; Fanciulli, M./titolo:HIPK2 sustains apoptotic response by phosphorylating Che-1%2FAATF and promoting its degradation/doi:10.1038%2Fcddis.2014.381/rivista:Cell death and disease/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume:5

Che-1/AATF is an RNA polymerase II-binding protein that is involved in the regulation of gene transcription, which undergoes stabilization and accumulation in response to DNA damage. We have previously demonstrated that following apoptotic induction,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbafbabb642a2199b96ce792c59f910
https://pubmed.ncbi.nlm.nih.gov/25210797

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Centrosomal Che-1 Protein Is Involved in the Regulation of Mitosis and DNA Damage Response by Mediating Pericentrin (PCNT)-dependent Chk1 Protein Localization

Autor: Enrico Cundari, Claudio Passananti, Simona Iezzi, Agata Desantis, Francesca De Nicola, Maria Grazia Di Certo, Maurizio Fanciulli, Valeria Catena, Aristide Floridi, Luciana Chessa, Cristina Sorino, Tiziana Bruno

Publikováno v: The Journal of biological chemistry
288 (2013): 23348–23357.
info:cnr-pdr/source/autori:Sorino C, Bruno T, Desantis A, Di Certo MG, Iezzi S, De Nicola F, Catena V, Floridi A, Chessa L, Passananti C, Cundari E, Fanciulli M./titolo:) Centrosomal Che-1 protein is involved in the regulation of mitosis and DNA damage response by mediating pericentrin (PCNT)-dependent Chk1 protein localization./doi:/rivista:The Journal of biological chemistry (Print)/anno:2013/pagina_da:23348/pagina_a:23357/intervallo_pagine:23348–23357/volume:288

To combat threats posed by DNA damage, cells have evolved mechanisms, collectively termed DNA damage response (DDR). These mechanisms detect DNA lesions, signal their presence, and promote their repair. Centrosomes integrate G2/M checkpoint control a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdac02d7d29a7e1cd608884cd3d73ac1
http://hdl.handle.net/11573/673237

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Novel activation domain derived from Che-1 cofactor coupled with the artificial protein Jazz drives utrophin upregulation

Autor: Agata Desantis, Elisabetta Mattei, Annalisa Onori, Claudio Passananti, Maurizio Fanciulli, Maria Grazia Di Certo, Nicoletta Corbi

Publikováno v: Neuromuscular disorders : NMD. 19(2)

Our aim is to upregulate the expression level of the dystrophin related gene utrophin in Duchenne muscular dystrophy, thus complementing the lack of dystrophin functions. To this end, we have engineered synthetic zinc finger based transcription facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a4fe2e6a8a6178ee0fd725f154962b
https://pubmed.ncbi.nlm.nih.gov/19162479

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Che-1 activates XIAP expression in response to DNA damage

Autor: M G Di Certo, M. Di Padova, F De Nicola, Agata Desantis, Simona Iezzi, M Scarsella, Carlo Leonetti, Claudio Passananti, Tommaso Bruno, Aristide Floridi, Maurizio Fanciulli

Publikováno v: Cell death and differentiation 15 (2008): 515–520. doi:10.1038/sj.cdd.4402284
info:cnr-pdr/source/autori:T Bruno; S Iezzi; F De Nicola; M Di Padova; A Desantis; M Scarsella; M G Di Certo; C Leonetti; A Floridi; C Passananti; M Fanciulli/titolo:Che-1 activates XIAP expression in response to DNA damage/doi:10.1038%2Fsj.cdd.4402284/rivista:Cell death and differentiation/anno:2008/pagina_da:515/pagina_a:520/intervallo_pagine:515–520/volume:15

X-linked inhibitor of apoptosis protein (XIAP) is a member of the inhibitor of apoptosis proteins family that selectively binds and inhibits caspase-3, -7 and -9. As such, XIAP is an extremely potent suppressor of apoptosis and an attractive target f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16fd959b3b8080bcc6a6fc643e81a2e3
http://www.cnr.it/prodotto/i/167457

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