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pro vyhledávání: '"Agata Adelajda Krygowska"'
Autor:
Esther Castellano, Miriam Molina-Arcas, Agata Adelajda Krygowska, Philip East, Patricia Warne, Alastair Nicol, Julian Downward
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blo
Externí odkaz:
https://doaj.org/article/2bae102d12544abe85cdc59962e710f8
Autor:
Julian Downward, Patricia H. Warne, Agata Adelajda Krygowska, Miriam Molina-Arcas, Alastair Nicol, Esther Castellano, Philip East
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
RAS signalling through phosphoinositide 3-kinase (PI3-Kinase) has been shown to have an essential role in tumour initiation and maintenance. RAS also regulates cell motility and tumour invasiveness, but the role of direct RAS binding to PI3-Kinase in
Publikováno v:
Cold Spring Harb Perspect Med
RAS proteins are key signaling switches essential for control of proliferation, differentiation, and survival of eukaryotic cells. RAS proteins are mutated in 30% of human cancers. In addition, mutations in upstream or downstream signaling components