Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Agata A. Bielska"'
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol
Autor:
David B. Iaea, Sarah E. Gale, Agata A. Bielska, Kathiresan Krishnan, Hideji Fujiwara, Hui Jiang, Frederick R. Maxfield, Paul H. Schlesinger, Douglas F. Covey, Jean E. Schaffer, Daniel S. Ory
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2408-2419 (2015)
Cholesterol homeostasis is regulated not only by cholesterol, but also by oxygenated cholesterol species, referred to as oxysterols. Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), regulate cholesterol homeostasis through feedback inhib
Externí odkaz:
https://doaj.org/article/b39cd01c69ac4c3ba074d9078dceaab5
Autor:
Craig B. Thompson, Wilhelm Palm, Quaid Morris, Yeon Ju Kyung, Caitlin F. Harrigan, Agata A. Bielska
Supplementary Data from Activating mTOR Mutations Are Detrimental in Nutrient-Poor Conditions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d70ff739f0fa1d73a0a3a558f9928cb
https://doi.org/10.1158/0008-5472.22432077.v1
https://doi.org/10.1158/0008-5472.22432077.v1
Autor:
Agata A. Bielska, Caitlin F. Harrigan, Yeon Ju Kyung, Quaid Morris, Wilhelm Palm, Craig B. Thompson
Publikováno v:
Cancer research. 82(18)
The mTOR is a key regulator of cell growth that integrates growth factor signaling and nutrient availability and is a downstream effector of oncogenic receptor tyrosine kinases (RTK) and PI3K/Akt signaling. Thus, activating mTOR mutations would be ex
Autor:
Craig B. Thompson, Agata A. Bielska
Publikováno v:
Journal of Biological Chemistry. 294:17883-17888
How cells utilize nutrients to produce the ATP needed for bioenergetic homeostasis has been well-characterized. What is less well-studied is how resting cells metabolically shift from an ATP-producing catabolic metabolism to a metabolism that support
Autor:
Rona Yaeger, Jinru Shia, Henry Walch, Diane Reidy-Lagunes, Agata A. Bielska, Nikolaus Schultz, Zsofia K. Stadler, Walid K. Chatila
Publikováno v:
J Natl Compr Canc Netw
Lynch syndrome is a heritable cancer syndrome caused by a heterozygous germline mutation in DNA mismatch repair (MMR) genes. MMR-deficient (dMMR) tumors are particularly sensitive to immune checkpoint inhibitors, an effect attributed to the higher mu
A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol
Autor:
Hideji Fujiwara, Agata A. Bielska, Jean E. Schaffer, Paul H. Schlesinger, Douglas F. Covey, Frederick R. Maxfield, David B. Iaea, Sarah E. Gale, Hui Jiang, Kathiresan Krishnan, Daniel S. Ory
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2408-2419 (2015)
Cholesterol homeostasis is regulated not only by cholesterol, but also by oxygenated cholesterol species, referred to as oxysterols. Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), regulate cholesterol homeostasis through feedback inhib
Autor:
Laurel Mydock-McGrane, Agata A. Bielska, Kathiresan Krishnan, Douglas F. Covey, Brett N. Olsen, Paul H. Schlesinger, Sarah E. Gale, Daniel S. Ory, Nathan A. Baker
Publikováno v:
Biochemistry
Side-chain oxysterols, such as 25-hydroxycholesterol (25-HC), are key regulators of cholesterol homeostasis. New evidence suggests that the alteration of membrane structure by 25-HC contributes to its regulatory effects. We have examined the role of
Publikováno v:
Journal of the American Chemical Society
Phosphorylation and OGlcNAcylation are dynamic intracellular protein post-translational modifications that frequently are alternatively observed on the same serine and threonine residues. Phosphorylation and OGlcNAcylation commonly occur in natively
Publikováno v:
Journal of Clinical Oncology. 37:394-394
394 Background: There are several therapies now available for panNETs, raising concern that treatment-related toxicity, namely myelosuppression, may preclude use of all treatments. AA are an effective therapy in panNETs, but can cause irreversible bo
Publikováno v:
Bioconjugate Chemistry. 20:1729-1736
Peptide nucleic acids (PNAs) have a number of attractive features that have made them an ideal choice for antisense and antigene-based tools, probes, and drugs, but their poor membrane permeability has limited their application as therapeutic or diag