Characterization of the interaction of nanobubble ultrasound contrast agents with human blood components

Autor: Michaela B. Cooley, Eric C. Abenojar, Dana Wegierak, Anirban Sen Gupta, Michael C. Kolios, Agata A. Exner

Publikováno v: Bioactive Materials, Vol 19, Iss , Pp 642-652 (2023)

Nanoscale ultrasound contrast agents, or nanobubbles, are being explored in preclinical applications ranging from vascular and cardiac imaging to targeted drug delivery in cancer. These sub-micron particles are approximately 10x smaller than clinical

Externí odkaz: https://doaj.org/article/8836ca84b8b24bdf83baf8b4c8919b36

A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis

Autor: Manse Kim, Claire E. Johnson, Alan A. Schmalstig, Ayano Annis, Sarah E. Wessel, Brian Van Horn, Amanda Schauer, Agata A. Exner, Jason E. Stout, Angela Wahl, Miriam Braunstein, J. Victor Garcia, Martina Kovarova

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Non-adherence to anti-tubercular therapy Mycobacterium tuberculosis infection can lead to treatment failure and even the development of drug resistance. In this work, the authors develop a long-acting delivery system of the anti-tuberculosis drug rif

Externí odkaz: https://doaj.org/article/78ca0bb18972453d8ccd4f196de8996e

Molecular imaging of orthotopic prostate cancer with nanobubble ultrasound contrast agents targeted to PSMA

Autor: Yu Wang, Al Christopher De Leon, Reshani Perera, Eric Abenojar, Ramamurthy Gopalakrishnan, James P. Basilion, Xinning Wang, Agata A. Exner

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Ultrasound imaging is routinely used to guide prostate biopsies, yet delineation of tumors within the prostate gland is extremely challenging, even with microbubble (MB) contrast. A more effective ultrasound protocol is needed that can effec

Externí odkaz: https://doaj.org/article/dfae35f73a544e6d9446108aa0e7a7a8

Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells

Autor: Monica M. Montano, I-Ju Yeh, Yinghua Chen, Chris Hernandez, Janna G. Kiselar, Maria de la Fuente, Adriane M. Lawes, Marvin T. Nieman, Philip D. Kiser, James Jacobberger, Agata A. Exner, Matthew C. Lawes

Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-15 (2019)

Abstract Background The tumor suppressor actions of hexamethylene bis-acetamide (HMBA)-inducible protein 1 (HEXIM1) in the breast, prostate, melanomas, and AML have been reported by our group and others. Increased HEXIM1 expression caused differentia

Externí odkaz: https://doaj.org/article/823d9e4c6c704698b65e256f03e474fe

Pharmacokinetic modeling of the Second-wave Phenomenon in Nanobubble-based Contrast-enhanced Ultrasound

Autor: Chuan Chen, Reshani Perera, Michael C. Kolios, Hessel Wijkstra, Agata A. Exner, Massimo Mischi, Simona Turco

Publikováno v: IEEE Transactions on Biomedical Engineering, 1-16. IEEE Computer Society
STARTPAGE=1;ENDPAGE=16;ISSN=0018-9294;TITLE=IEEE Transactions on Biomedical Engineering
IEEE Transactions on Biomedical Engineering, 70(1), 42-54. IEEE Computer Society

With a typical 100 - 500 nm diameter, nanobubbles are a promising new-generation ultrasound contrast agent that paves ways for several applications, such as efficient drug delivery, molecular imaging, and assessment of vascular permeability. Due to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6bb08cde70e9d6f2285b293b24ab8e
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