Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Agapitos Patakas"'
Autor:
Agapitos Patakas, Naveen K Mehta, Patrick A Baeuerle, Jennifer S Michaelson, Kristan A Meetze, Hannah M Findlay, Timothy B London
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/f2b395f518b64e4c863b991e59b9aec8
Autor:
Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 8 (2023)
Background Despite significant progress in the development of T cell-engaging therapies for various B-cell malignancies, a high medical need remains for the refractory disease setting, often characterized by suboptimal target levels.Methods To addres
Externí odkaz:
https://doaj.org/article/03625d161242477f821871a5ae3d1af8
Autor:
Robert A Benson, Megan KL MacLeod, Benjamin G Hale, Agapitos Patakas, Paul Garside, James M Brewer
Publikováno v:
eLife, Vol 4 (2015)
The production of high affinity, class switched antibodies produced by B cells hinges on the effective differentiation of T follicular helper (Tfh) cells. Here we define conditions specifically enhancing Tfh differentiation and providing protection i
Externí odkaz:
https://doaj.org/article/323f359a597c418eb6ade14903776202
Autor:
Agapitos Patakas, Robert A Benson, David R Withers, Paola Conigliaro, Iain B McInnes, James M Brewer, Paul Garside
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49715 (2012)
Th17 cells are pro-inflammatory CD4⁺T cells, which are important in immune responses against fungal pathogens and extracellular bacteria and have also been implicated in various autoimmune syndromes. However, their role in supporting B cell respons
Externí odkaz:
https://doaj.org/article/3dca14ce508f4cf8b94d4bdaa30d1d92
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071601709
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25c7cb914a97b0a266e4afde9e3327d5
https://doi.org/10.1007/978-1-0716-0171-6_6
https://doi.org/10.1007/978-1-0716-0171-6_6
Autor:
Rui-Ru Ji, Paul Garside, Steven G. Nadler, James M. Brewer, William Weir, Agapitos Patakas, Sean E. Connolly, Iain B. McInnes, Robert A. Benson
Publikováno v:
Arthritis & Rheumatology. 68:627-638
Objective To determine at the phenotypic, functional, and transcriptional levels whether abatacept, a CTLA-4Ig molecule that binds with high affinity to CD80/86 on antigen-presenting cells (APCs) and is used to treat rheumatoid arthritis, induces a s
Autor:
Andrew M. Platt, Anneli Cooper, Annette MacLeod, William Weir, Mamadou Camara, Kerry O'Neill, Agapitos Patakas, Heli Vaikkinen, Paul Capewell, Caroline Clucas, Paul Garside, Taylor-Anne Gorman, Vincent Jamonneau, Bruno Bucheton, Hamidou Ilboudo
Infections by many pathogens can result in a wide range of phenotypes, from severe to mild, or even asymptomatic. Understanding the genetic basis of these phenotypes can lead to better tools to treat patients or detect reservoirs. To identify human g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c12e36ff65d3205dc44a7a823ea8c0
https://doi.org/10.1101/184762
https://doi.org/10.1101/184762
Autor:
James M. Brewer, Robert A. Benson, Catriona T. Prendergast, Iain B. McInnes, Shaima Al-Khabouri, Agapitos Patakas, Paul Garside, Claire L. McIntyre
Publikováno v:
Annals of the rheumatic diseases. 77(4)
ObjectivesSuccessful early intervention in rheumatoid arthritis (RA) with the aim of resetting immunological tolerance requires a clearer understanding of how specificity, cellular kinetics and spatial behaviour shape the evolution of articular T cel
Autor:
Robert A. Benson, Agapitos Patakas, Vivienne B. Gibson, James M. Brewer, Paul Garside, Iain B. McInnes, Steven G. Nadler, Andrew M. Platt
Publikováno v:
The Journal of Immunology. 185:1558-1567
Abatacept modulates CD28-mediated T cell costimulation and is efficacious in the treatment of rheumatoid arthritis (RA). Its mechanism of action has not been fully elucidated but will likely reveal critical pathologic pathways in RA. We show that aba
Autor:
Wanda Niedbala, Beilei Cai, Bernard P. Leung, Xiao-Qing Wei, Iain B. McInnes, Agapitos Patakas, Foo Y. Liew
Publikováno v:
Annals of the Rheumatic Diseases. 67:1474-1479
Objective: To investigate the potential role of interleukin (IL) 27 in rheumatoid arthritis (RA) by examining the expression of IL27 in the articular joints of patients with RA and the effect of recombinant IL27 in vivo in a murine model of collagen-