Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus

Autor: Ag, Tomasselli, Jo, Hui, Adams L, Chosay J, David Lowery, Greenberg B, Yem A, Deibel MR, Zürcher-Neely H, Rl, Heinrikson

Publikováno v: Europe PubMed Central

We show here for the first time that actin, troponin C, Alzheimer amyloid precursor protein (AAP), and pro-interleukin 1 beta (pro-IL-1 beta), are substrates of the protease encoded by the human immunodeficiency virus (HIV) type-1. As has been seen i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8171e84dfdfcf689eaa80cd812fad3c8
http://europepmc.org/abstract/med/1907279

Differential kinetics and inhibition of purified recombinant tyrosine kinase 2 (TYK-2) and its catalytic domain JH-1.

Autor: Emmons TL; Pfizer Global Research and Development, St. Louis Laboratories, 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. Thomas.l.emmons@pfizer.com, Wrightstone AD, Baima ET, Brown S, Sommers CD, Hirsch JL, Pegg LE, Weinberg RA, Fischer HD, Wittwer AJ, Tomasselli AG

Publikováno v: Protein and peptide letters [Protein Pept Lett] 2012 May; Vol. 19 (5), pp. 485-91.

Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.

Autor: Wang Z; Oligonucleotide Therapeutics Unit, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA. zhigang.wang@pfizer.com, Watt W, Brooks NA, Harris MS, Urban J, Boatman D, McMillan M, Kahn M, Heinrikson RL, Finzel BC, Wittwer AJ, Blinn J, Kamtekar S, Tomasselli AG

Publikováno v: Biochimica et biophysica acta [Biochim Biophys Acta] 2010 Sep; Vol. 1804 (9), pp. 1817-31. Date of Electronic Publication: 2010 May 24.

Expression, purification, and characterization of TYK-2 kinase domain, a member of the Janus kinase family.

Autor: Korniski B; Pfizer Inc, Global Research and Development, St Louis Laboratories, 700 Chesterfield Parkway West, St Louis, MO 63017-1732, USA., Wittwer AJ, Emmons TL, Hall T, Brown S, Wrightstone AD, Hirsch JL, Gormley JA, Weinberg RA, Leone JW, Day JE, Chrencik JE, Sommers CD, Fischer HD, Tomasselli AG

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2010 May 28; Vol. 396 (2), pp. 543-8. Date of Electronic Publication: 2010 May 08.

ADAM8 substrate specificity: influence of pH on pre-processing and proteoglycan degradation.

Autor: Hall T; Pfizer Inc., Global Research and Development, St. Louis Laboratories, St. Louis, MO 63017-1732, USA., Pegg LE, Pauley AM, Fischer HD, Tomasselli AG, Zack MD

Publikováno v: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2009 Nov; Vol. 491 (1-2), pp. 106-11. Date of Electronic Publication: 2009 Sep 18.