Efficacy and safety of gefapixant in women with chronic cough and cough-induced stress urinary incontinence: a phase 3b, randomised, multicentre, double-blind, placebo-controlled trial

Autor: Birring, Surinder S, Cardozo, Linda ^*, Dmochowski, Roger, Dicpinigaitis, Peter, Afzal, Amna, La Rosa, Carmen, Lu, Susan, Nguyen, Allison Martin, Yao, Ruji, Reyfman, Paul A ^*

Publikováno v: In The Lancet Respiratory Medicine November 2024 12(11):855-864

The Efficacy and Safety of Gefapixant in a Phase 3b Trial of Patients with Recent-Onset Chronic Cough

Autor: McGarvey, Lorcan, Sher, Mandel, Shvarts, Yury Grigorievich, Lu, Susan, Wu, Wen-Chi, Xu, Ping, Schelfhout, Jonathan, La Rosa, Carmen, Nguyen, Allison Martin, Reyfman, Paul A., Afzal, Amna Sadaf

Publikováno v: McGarvey, L, Sher, M, Shvarts, Y G, Lu, S, Wu, W-C, Xu, P, Schelfhout, J, La Rosa, C, Nguyen, A M, Reyfman, P A & Afzal, A S 2023, ' The efficacy and safety of gefapixant in a phase 3b trial of patients with recent-onset chronic cough ', Lung . https://doi.org/10.1007/s00408-023-00606-w

Purpose We evaluated gefapixant, a P2X3 receptor antagonist, in participants with recent-onset (≤ 12 months) refractory chronic cough (RCC) or unexplained chronic cough (UCC). Methods Participants (≥ 18 years of age; ≥ 40 mm on a 100-mm cough s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4b31f8dafcc1e8fcf28110c8f97217
https://doi.org/10.1007/s00408-023-00606-w

Treatment of Persistent Cough in Subjects with Idiopathic Pulmonary Fibrosis (IPF) with Gefapixant, a P2X3 Antagonist, in a Randomized, Placebo-Controlled Clinical Trial.

Autor: Martinez, Fernando J.¹ (AUTHOR) fjm2003@med.cornell.edu, Afzal, Amna Sadaf² (AUTHOR), Smith, Jaclyn A.³ (AUTHOR), Ford, Anthony P.² (AUTHOR), Li, Jerry Jing² (AUTHOR), Li, Yuping⁴ (AUTHOR), Kitt, Michael M.² (AUTHOR), the Chronic Cough in IPF Study Group (AUTHOR), Hussain, Iftikhar (AUTHOR), Sher, Mandel (AUTHOR), Spangenthal, Selwyn (AUTHOR), Fakih, Faisal (AUTHOR), Gotfried, Mark (AUTHOR), Flaherty, Kevin (AUTHOR), Lancaster, Lisa (AUTHOR), Horton, Maureen (AUTHOR), Kaner, Robert (AUTHOR), Patel, Kapil (AUTHOR), Scholand, Mary Beth (AUTHOR), Sussman, Robert (AUTHOR)

Publikováno v: Pulmonary Therapy. Dec2021, Vol. 7 Issue 2, p471-486. 16p.

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