Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Afsoon Saadin"'
Autor:
Fahad Mubariz, Afsoon Saadin, Nicholas Lingenfelter, Chinmoy Sarkar, Aditi Banerjee, Marta M. Lipinski, Ola Awad
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Mutations in the GBA1 gene are the single most frequent genetic risk factor for Parkinson’s disease (PD). Neurodegenerative changes in GBA1-associated PD have been linked to the defective lysosomal clearance of autophagic substrates and aggregate-p
Externí odkaz:
https://doaj.org/article/0f914e2d22a64207b8445354ba5f321e
Autor:
Jacquelyn C. Serfecz, Afsoon Saadin, Clayton P. Santiago, Yuji Zhang, Søren M. Bentzen, Stefanie N. Vogel, Ricardo A. Feldman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9912 (2021)
Gaucher disease (GD) is an autosomal recessive disorder caused by bi-allelic GBA1 mutations that reduce the activity of the lysosomal enzyme β-glucocerebrosidase (GCase). GCase catalyzes the conversion of glucosylceramide (GluCer), a ubiquitous glyc
Externí odkaz:
https://doaj.org/article/43f08b6566b646268629b3a0f21c35e1
Autor:
Afsoon Saadin, Michelle Starz-Gaiano
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 7, Pp 1991-2002 (2016)
The Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) signaling pathway is an essential regulator of cell migration both in mammals and fruit flies. Cell migration is required for normal embryonic development and immune respons
Externí odkaz:
https://doaj.org/article/984841c0ff484d9a8cc9f4cfb1a5acf7
Autor:
Stacey Bridges, Afsoon Saadin, Susan A. Spencer, Kamsi Odinammadu, Lathiena Manning, Denise J. Montell, Deborah J. Andrew, Jinal Sheth, Michelle Starz-Gaiano
Publikováno v:
Mechanisms of Development. 148:56-68
Cell migration is essential during animal development. In the Drosophila ovary, the steroid hormone ecdysone coordinates nutrient sensing, growth, and the timing of morphogenesis events including border cell migration. To identify downstream effector
Autor:
Afsoon Saadin, Clayton Santiago, Ricardo A. Feldman, Yuji Zhang, Søren M. Bentzen, Stefanie N. Vogel, Jacquelyn C Serfecz
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 9912, p 9912 (2021)
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 9912, p 9912 (2021)
Gaucher disease (GD) is an autosomal recessive disorder caused by bi-allelic GBA1 mutations that reduce the activity of the lysosomal enzyme β-glucocerebrosidase (GCase). GCase catalyzes the conversion of glucosylceramide (GluCer), a ubiquitous glyc
Autor:
Afsoon, Saadin, Michelle, Starz-Gaiano
Publikováno v:
Journal of cell science. 131(23)
How vesicle trafficking components actively contribute to regulation of paracrine signaling is unclear. We genetically uncovered a requirement for α-soluble NSF attachment protein (α-Snap) in the activation of the Janus kinase/signal transducer and