Zobrazeno 1 - 10 of 99 pro vyhledávání: '"Afsie Sabokbar"'
1
Akademický článek
The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory 'M1' human macrophages.
Autor: Nehal Narayan, Harpreet Mandhair, Erica Smyth, Stephanie Georgina Dakin, Serafim Kiriakidis, Lisa Wells, David Owen, Afsie Sabokbar, Peter Taylor
Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185767 (2017)
The translocator protein (TSPO) is a mitochondrial membrane protein, of as yet uncertain function. Its purported high expression on activated macrophages, has lent utility to TSPO targeted molecular imaging in the form of positron emission tomography
Externí odkaz: https://doaj.org/article/46df36bed96943b6abef8b02efb6976b
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2
Akademický článek
25-Hydroxy- and 1α,25-Dihydroxycholecalciferol Have Greater Potencies than 25-Hydroxy- and 1α,25-Dihydroxyergocalciferol in Modulating Cultured Human and Mouse Osteoblast Activities.
Autor: Allahdad Zarei, Philippa A Hulley, Afsie Sabokbar, M Kassim Javaid, Alireza Morovat
Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165462 (2016)
Despite differences in the phamacokinetics of 25-hydroxycholecalciferol (25(OH)D3) and 25-hydroxyergocalciferol (25(OH)D2) in man, the effects of these and their 1α-hydroxylated forms (1,25(OH)2D3 and 1,25(OH)2D2) on cellular activity of vitamin D-r
Externí odkaz: https://doaj.org/article/457c3a54886f4d8a8b4ee1c8092d81cc
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3
Akademický článek
Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
Autor: Guillaume Mabilleau, Afsie Sabokbar
Publikováno v: PLoS ONE, Vol 4, Iss 1, p e4173 (2009)
BackgroundInterleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently
Externí odkaz: https://doaj.org/article/d8f089eeaf8448e3bc8fe2b9b0aa2d38
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4
Akademický článek
A Surgeon's guide to advances in the pharmacological management of acute Charcot neuroarthropathy
Autor: Al-Nammari, Shafic Said, Timothy, Theologis, Afsie, Sabokbar
Publikováno v: In Foot and Ankle Surgery December 2013 19(4):212-217
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5
Translocator Protein as an Imaging Marker of Macrophage and Stromal Activation in Rheumatoid Arthritis Pannus
Autor: Azeem Saleem, Peter C. Taylor, Francesco Carlucci, Roger N. Gunn, Harpreet Mandhair, Stephanie G. Dakin, Afsie Sabokbar, Lisa Wells, David R. Owen, Erica Smyth, Nehal Narayan, Eugenii A. Rabiner
Publikováno v: Journal of Nuclear Medicine. 59:1125-1132
PET radioligands targeted to translocator protein (TSPO) offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of TSPO on activated macrophages, TSPO PET has been widely report
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d11a6334dc4c25c9d4961bcb71b2d87
https://doi.org/10.2967/jnumed.117.202200
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7
Periostin expression in neoplastic and non-neoplastic diseases of bone and joint
Autor: Udo Oppermann, Afsie Sabokbar, Nicholas A. Athanasou, Akiro Kudo, A. Bass Hassan, J. M. Brown, Akiro Mantoku
Publikováno v: Clinical Sarcoma Research, Vol 8, Iss 1, Pp 1-8 (2018)
Clinical Sarcoma Research
Background Periostin is a matricellular protein that is expressed in bone and joint tissues. To determine the expression of periostin in primary bone tumours and to assess whether it plays a role in tumour progression, we carried out immunohistochemi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e9cd836ab128519ad25b644d6e0eb4
https://doi.org/10.1186/s13569-018-0105-y
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8
THU0088 Monocyte downregulation of mitochondrial translocator protein may be a contributory mechanism to inflammation in ra
Autor: Nehal Narayan, Takuya Sekine, Harpreet Mandhair, Peter C. Taylor, Afsie Sabokbar
Publikováno v: THURSDAY, 14 JUNE 2018.
Background The translocator protein is an 18 kDa mitochondrial transporter, increasingly thought to play a critical role in cholesterol efflux in macrophages. Recent work demonstrates that macrophages engineered to over-express TSPO, exhibit increase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24fad349fa6e827542dd52f62cefe74a
https://doi.org/10.1136/annrheumdis-2018-eular.1213
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10
AB1045 Macrophage targeted positron emission tomography (PET) for the imaging of inflammatory arthritis; an in vivo and in vitro investigation of translocator protein (TSPO) tracer uptake
Autor: C Coello, Harpreet Mandhair, Peter C. Taylor, Afsie Sabokbar, Nehal Narayan, A Saleem
Publikováno v: Abstracts Accepted for Publication.
Background TSPO targeted PET tracers are increasingly recognised as cellular imaging markers of macrophage infiltration, due to the high expression of TSPO on activated macrophages. Previous work demonstrated the ability of [11C]PK11195 TSPO PET to d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12ed814901c1388972e1d02c090d85c
https://doi.org/10.1136/annrheumdis-2017-eular.1838
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