Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Afshin Varzavand"'
Autor:
Melissa A. Marchal, Devon L. Moose, Afshin Varzavand, Nicole E. Jordan, Destiney Taylor, Munir R. Tanas, James A. Brown, Michael D. Henry, Christopher S. Stipp
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionAbl family kinases function as proto-oncogenes in various leukemias, and pro-tumor functions have been discovered for Abl kinases in many solid tumors as well. However, a growing body of evidence indicates that Abl kinases can function to
Externí odkaz:
https://doaj.org/article/3f74f3b22e7d4202910ff27fb642931d
Autor:
Marion Vanneste, Charlotte R. Feddersen, Afshin Varzavand, Elliot Y. Zhu, Tyler Foley, Lei Zhao, Kathleen H. Holt, Mohammed Milhem, Robert Piper, Christopher S. Stipp, Adam J. Dupuy, Michael D. Henry
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Patients with malignant melanoma have a 5-year survival rate of only 15–20% once the tumor has metastasized to distant tissues. While MAP kinase pathway inhibitors (MAPKi) are initially effective for the majority of patients with melanoma harboring
Externí odkaz:
https://doaj.org/article/95a586feb3bf41228e4c027d0dc87c64
Autor:
Christopher S. Stipp, Michael D. Henry, James A. Brown, Omar J. Tayh, Maria Hawayek, Katherine Gibson-Corley, Deqin Ma, Will Hacker, Afshin Varzavand
RNAi targeting sequences, Supplemental Figure Legends, & Supplemental Figures S1-S11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1e8c9a786fce05f0ebec40a479614a
https://doi.org/10.1158/0008-5472.22412457.v1
https://doi.org/10.1158/0008-5472.22412457.v1
Autor:
Adam J. Dupuy, Christopher S. Stipp, Jesse D. Riordan, Jeremy Bobera, Sarah A. Mullen, Brooke M. Jennings, Eliot Y. Zhu, Andrew P. Voigt, Lexy S. Wadsworth, Hayley R. Vaughn, Afshin Varzavand, Jacob L. Schillo, Charlotte R. Feddersen
The use of selective BRAF inhibitors (BRAFi) has produced remarkable outcomes for patients with advanced cutaneous melanoma harboring a BRAFV600E mutation. Unfortunately, the majority of patients eventually develop drug-resistant disease. We employed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaeb0dd15610b75d4835c5c2b200b47
https://doi.org/10.1158/0008-5472.c.6510806
https://doi.org/10.1158/0008-5472.c.6510806
Autor:
Christopher S. Stipp, Michael D. Henry, James A. Brown, Omar J. Tayh, Maria Hawayek, Katherine Gibson-Corley, Deqin Ma, Will Hacker, Afshin Varzavand
Existing anticancer strategies focused on disrupting integrin functions in tumor cells or tumor-involved endothelial cells have met limited success. An alternative strategy is to augment integrin-mediated pathways that suppress tumor progression, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77736241c7f424440a1cc483061cf2d9
https://doi.org/10.1158/0008-5472.c.6508446.v1
https://doi.org/10.1158/0008-5472.c.6508446.v1
Autor:
Adam J. Dupuy, Christopher S. Stipp, Jesse D. Riordan, Jeremy Bobera, Sarah A. Mullen, Brooke M. Jennings, Eliot Y. Zhu, Andrew P. Voigt, Lexy S. Wadsworth, Hayley R. Vaughn, Afshin Varzavand, Jacob L. Schillo, Charlotte R. Feddersen
Supplemental figures showing more detailed analysis of the genetic screen results (S1-S3), additional experiments showing biological validation of major candidate genes (S4-S7), and characterization of spontaneous Vemurafenib resistance in A375 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763c2810c62639764eae9b5898ddc732
https://doi.org/10.1158/0008-5472.22420994
https://doi.org/10.1158/0008-5472.22420994
Autor:
Adam J. Dupuy, Christopher S. Stipp, Jesse D. Riordan, Jeremy Bobera, Sarah A. Mullen, Brooke M. Jennings, Eliot Y. Zhu, Andrew P. Voigt, Lexy S. Wadsworth, Hayley R. Vaughn, Afshin Varzavand, Jacob L. Schillo, Charlotte R. Feddersen
This file contains 4 supplemental tables.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb40e1219583d6c2b577a68cb4a9de0
https://doi.org/10.1158/0008-5472.22420997.v1
https://doi.org/10.1158/0008-5472.22420997.v1
Publikováno v:
Experimental dermatologyREFERENCES.
sCD48 is elevated in diseases characterized by IgE and eosinophilia. Thus, serum levels sCD48 were evaluated in relation to clinical characteristics of Bullous pemphigoid (BP) patients. sCD48 levels were determined by ELISA in sera from 26 patients w
Autor:
Jeremy Bobera, Charlotte R. Feddersen, Sarah A. Mullen, Jesse D. Riordan, Lexy S. Wadsworth, Jacob L. Schillo, Adam J. Dupuy, Hayley R. Vaughn, Christopher S. Stipp, Brooke M. Jennings, Andrew P. Voigt, Afshin Varzavand, Eliot Y. Zhu
Publikováno v:
Cancer Research. 79:5074-5087
The use of selective BRAF inhibitors (BRAFi) has produced remarkable outcomes for patients with advanced cutaneous melanoma harboring a BRAFV600E mutation. Unfortunately, the majority of patients eventually develop drug-resistant disease. We employed
Abl kinase deficiency promotes AKT pathway activation and prostate cancer progression and metastasis
Autor:
Christopher S. Stipp, Devon L. Moose, Michael D. Henry, James A. Brown, Melissa A Marchal, Afshin Varzavand, Destiney Taylor
Abl family kinases function as proto-oncogenes in various leukemias, and pro-tumor functions have been discovered for Abl kinases in solid tumors as well. However, a growing body of evidence indicates that Abl kinases can function to suppress tumor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e94386942fec6f6248e0c0fa2cc4cfd
https://doi.org/10.1101/2020.05.19.104679
https://doi.org/10.1101/2020.05.19.104679