Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Afshin Ghavami"'
Autor:
Taneli Heikkinen, Timo Bragge, Juha Kuosmanen, Teija Parkkari, Sanna Gustafsson, Mei Kwan, Jose Beltran, Afshin Ghavami, Srinivasa Subramaniam, Neelam Shahani, Uri Nimrod Ramírez-Jarquín, Larry Park, Ignacio Muñoz-Sanjuán, Deanna M Marchionini
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)
Huntington's disease (HD) results from an expansion mutation in the polyglutamine tract in huntingtin. Although huntingtin is ubiquitously expressed in the body, the striatum suffers the most severe pathology. Rhes is a Ras-related small GTP-binding
Externí odkaz:
https://doaj.org/article/5d08393a3e9247bea54802339f2736c8
Autor:
Mei Yee Kwan, Anthony Choo, Taleen Hanania, Afshin Ghavami, Jose Beltran, John Shea, Amidi Barboza, Andrew Hu, Marcie Fowler, Venugopal Rao Neelagiri, Irving Sucholeiki
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 4, p 811 (2019)
There is an unmet medical need for the development of non-addicting pain therapeutics with enhanced efficacy and tolerability. The current study examined the effects of AQU-118, an orally active inhibitor of metalloproteinase-2 (MMP-2) and MMP-9, in
Externí odkaz:
https://doaj.org/article/06f248ac70a1486d87796cfb356b0157
Autor:
Liliana B Menalled, Andrea E Kudwa, Steve Oakeshott, Andrew Farrar, Neil Paterson, Igor Filippov, Sam Miller, Mei Kwan, Michael Olsen, Jose Beltran, Justin Torello, Jon Fitzpatrick, Richard Mushlin, Kimberly Cox, Kristi McConnell, Matthew Mazzella, Dansha He, Georgina F Osborne, Rand Al-Nackkash, Gill P Bates, Pasi Tuunanen, Kimmo Lehtimaki, Dani Brunner, Afshin Ghavami, Sylvie Ramboz, Larry Park, Douglas Macdonald, Ignacio Munoz-Sanjuan, David Howland
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99520 (2014)
Huntington's disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by expansion of CAG repeats in the huntingtin gene. Tissue transglutaminase 2 (TG2), a multi-functional enzyme, was found to be increased both in HD pat
Externí odkaz:
https://doaj.org/article/32ac64f0a9ee4c26afbcfdfbe927af3c
Autor:
Liliana B Menalled, Andrea E Kudwa, Sam Miller, Jon Fitzpatrick, Judy Watson-Johnson, Nicole Keating, Melinda Ruiz, Richard Mushlin, William Alosio, Kristi McConnell, David Connor, Carol Murphy, Steve Oakeshott, Mei Kwan, Jose Beltran, Afshin Ghavami, Dani Brunner, Larry C Park, Sylvie Ramboz, David Howland
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e49838 (2012)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by motor, cognitive and psychiatric manifestations. Since the mutation responsible for the disease was identified as an unstable expansion of CAG repeats in t
Externí odkaz:
https://doaj.org/article/7b9395c26cd34e0482a329a3cc5cbeb5
Publikováno v:
Journal of Alzheimer's Disease. 77:1383-1388
The timing of action potentials arrival at synaptic terminals partially determines integration of synaptic inputs and is important for information processing in the CNS. Therefore, axonal conduction velocity (VC) is a salient parameter, influencing t
Autor:
Mei Kwan, Fernando E. Padovan-Neto, Anthony R. West, Conor H. Murray, Lauren Jurkowski, Grace E. Stutzmann, Afshin Ghavami, Vahri Beaumont, Larry Park
Publikováno v:
Nitric Oxide. 83:40-50
In Huntington's disease (HD), corticostriatal and striatopallidal projection neurons preferentially degenerate as a result of mutant huntingtin expression. Pathological deficits in nitric oxide (NO) signaling have also been reported in corticostriata
Autor:
Jose Beltran, Teija Parkkari, Sanna Gustafsson, Neelam Shahani, Afshin Ghavami, Larry Park, Taneli Heikkinen, Mei Kwan, Deanna Marchionini, Srinivasa Subramaniam, Juha Kuosmanen, Uri Nimrod Ramírez-Jarquín, Timo Bragge, Ignacio Munoz-Sanjuan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258486 (2021)
Huntington’s disease (HD) results from an expansion mutation in the polyglutamine tract in huntingtin. Although huntingtin is ubiquitously expressed in the body, the striatum suffers the most severe pathology. Rhes is a Ras-related small GTP-bindin
Publikováno v:
Journal of Alzheimer's Disease
Genetically modified mice have provided insights into the progression and pathology of Alzheimer's disease (AD). Here, we have examined two mouse models of AD: the rTg4510 mouse, which overexpresses mutant human Tau gene, and the APP/PS1 mouse, which
Autor:
Taneli Heikkinen, J. Nikolaj Dybowski, Larry Park, Fernando E. Padovan-Neto, Amyaouch Bradaia, John F. Harms, Vahri Beaumont, Miklós Tóth, Esther Steidl, Sheng Zhong, Margaret M. Zaleska, Kristian Wadel, Ladislav Mrzljak, Kimmo Lehtimäki, Karen M. Ward, Shreaya Chakroborty, Sarah Elschenbroich, Christer Halldin, Andrea Varrone, Christopher J. Schmidt, Afshin Ghavami, WenJin Xu, Ignacio Munoz-Sanjuan, Mei Kwan, Jose Beltran, Bruno Buisson, Christoph Schaab, Jim Rosinski, Daniel J. Lavery, Anthony R. West, Jenny Häggkvist, Melanie Gleyzes, Hai Lin
Publikováno v:
Neuron. 92:1220-1237
Summary Huntington's disease (HD) symptoms are driven to a large extent by dysfunction of the basal ganglia circuitry. HD patients exhibit reduced striatal phoshodiesterase 10 (PDE10) levels. Using HD mouse models that exhibit reduced PDE10, we demon
Autor:
Igor Filipov, Vanessa C. Wheeler, Matthew J. Mazzella, Liliana B. Menalled, Melinda C Ruiz, Ana Sanchez, Sylvie Ramboz, Brenda Lager, Marcy E. MacDonald, Ian Russell, Kimberly Cox, Miguel A. Gomez, Afshin Ghavami, Vadim Alexandrov, Seung Kwak, Dani Brunner, Justin Torello, Jeff Aaronson, Mei Kwan, Andrea E. Kudwa, James F. Gusella, Judy Watson-Johnson, Jim Rosinski, David Howland, Emily Sabath
Publikováno v:
Nature Biotechnology. 34:838-844
Rapid technological advances for the frequent monitoring of health parameters have raised the intriguing possibility that an individual's genotype could be predicted from phenotypic data alone. Here we used a machine learning approach to analyze the