Binding of nucleoid-associated protein fis to DNA is regulated by DNA breathing dynamics.

Autor: Kristy Nowak-Lovato, Ludmil B Alexandrov, Afsheen Banisadr, Amy L Bauer, Alan R Bishop, Anny Usheva, Fangping Mu, Elizabeth Hong-Geller, Kim Ø Rasmussen, William S Hlavacek, Boian S Alexandrov

Publikováno v: PLoS Computational Biology, Vol 9, Iss 1, p e1002881 (2013)

Physicochemical properties of DNA, such as shape, affect protein-DNA recognition. However, the properties of DNA that are most relevant for predicting the binding sites of particular transcription factors (TFs) or classes of TFs have yet to be fully

Externí odkaz: https://doaj.org/article/e7bab5c0269041c2b9824b11423a177d

Data from Cell Adhesiveness Serves as a Biophysical Marker for Metastatic Potential

Autor: Adam J. Engler, Parag Katira, Stephanie I. Fraley, Hannah Carter, Jesse K. Placone, Afsheen Banisadr, Alyssa Chiang, Enio Hodzic, Kevin Chen, Aditya Kumar, Benjamin Yeoman, Anna Popravko, Pranjali Beri

Tumors are heterogeneous and composed of cells with different dissemination abilities. Despite significant effort, there is no universal biological marker that serves as a metric for metastatic potential of solid tumors. Common to disseminating cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4a719881819138b42995e5ca7ad8c9
https://doi.org/10.1158/0008-5472.c.6512295

EGFRvIII uses intrinsic and extrinsic mechanisms to reduce glioma adhesion and increase migration

Autor: Jesse K. Placone, Benjamin Yeoman, Frank B. Furnari, Mariam Eick, Pranjali Beri, Afsheen Banisadr, Alison Parisian, Adam J. Engler

Publikováno v: J Cell Sci

A lack of biological markers has limited our ability to identify the invasive cells responsible for glioblastoma multiforme (GBM). To become migratory and invasive, cells must downregulate matrix adhesions, which could be a physical marker of invasiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938135d05fb9401848a9345ca24d4649
https://pubmed.ncbi.nlm.nih.gov/33243756

Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength

Autor: Adam J. Engler, Afsheen Banisadr, Alexander Fuhrmann, Pranjali Beri, Thea D. Tlsty

Publikováno v: Fuhrmann, A; Banisadr, A; Beri, P; Tlsty, TD; & Engler, AJ. (2017). Metastatic State of Cancer Cells May Be Indicated by Adhesion Strength. BIOPHYSICAL JOURNAL, 112(4), 736-745. doi: 10.1016/j.bpj.2016.12.038. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9qh2p3sg
Biophysical journal, vol 112, iss 4

Cancer cells within a tumor are heterogeneous and only a small fraction are able to form secondary tumors. Universal biological markers that clearly identify potentially metastatic cells are limited, which complicates isolation and further study. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8893772fe8f00ff063665687eae227b
https://pubmed.ncbi.nlm.nih.gov/28256233

Binding of Nucleoid-Associated Protein Fis to DNA Is Regulated by DNA Breathing Dynamics

Autor: William S. Hlavacek, Kristy L. Nowak-Lovato, Afsheen Banisadr, Anny Usheva, Ludmil B. Alexandrov, Elizabeth Hong-Geller, Fangping Mu, Boian S. Alexandrov, Amy L. Bauer, Kim Ø. Rasmussen, Alan R. Bishop

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Vol 9, Iss 1, p e1002881 (2013)

Physicochemical properties of DNA, such as shape, affect protein-DNA recognition. However, the properties of DNA that are most relevant for predicting the binding sites of particular transcription factors (TFs) or classes of TFs have yet to be fully

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9121654dc4db223e6928eef7a682d434
http://europepmc.org/articles/PMC3547798