Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Afroditi Mertzanidou"'
Autor:
Kurt Jacobs, Filippo Zambelli, Afroditi Mertzanidou, Ilse Smolders, Mieke Geens, Ha Thi Nguyen, Lise Barbé, Karen Sermon, Claudia Spits
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 330-341 (2016)
Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate that medium acidification linked
Externí odkaz:
https://doaj.org/article/4222fde08724456886ef948b0fcfc442
Autor:
Mieke Geens, Kurt Jacobs, Lise Barbé, Claudia Spits, Afroditi Mertzanidou, Ha Thi Nguyen, Karen Sermon, Ilse Julia Smolders, Filippo Zambelli
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 330-341 (2016)
Stem Cell Reports
Stem Cell Reports
Summary Human embryonic stem cells (hESC) show great promise for clinical and research applications, but their well-known proneness to genomic instability hampers the development to their full potential. Here, we demonstrate that medium acidification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b40e6fe2c1d6c39e9f3720f763af10
https://doi.org/10.1016/j.stemcr.2016.01.015
https://doi.org/10.1016/j.stemcr.2016.01.015
Autor:
Ha Thi Nguyen, Claudia Spits, Carlo Heirman, Mieke Geens, K. Jacobs, Karine Breckpot, Afroditi Mertzanidou
Publikováno v:
MHR: Basic science of reproductive medicine. 20:168-177
Gain of 20q11.21 is a chromosomal abnormality that is recurrently found in human pluripotent stem cells and cancers, strongly suggesting that this mutation confers a proliferative or survival advantage to these cells. In this work we studied three hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e29a1379a2b214f9d909e0fcce87e95
https://doi.org/10.1093/molehr/gat077
https://doi.org/10.1093/molehr/gat077
Publikováno v:
Vrije Universiteit Brussel
Study question: What is the incidence of aneuploidy and mosaicism in all cells of top-quality Day-4 embryos analysed by array-based comparative genomic hybridization (array CGH)? Summary answer: Our data show extensive abnormalities in Day-4 embryos.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ece48adf2dd771eb28c6671bf5dab1
https://doi.org/10.1093/humrep/det079
https://doi.org/10.1093/humrep/det079
Publikováno v:
Human reproduction (Oxford, England). 32(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d274a8c6268e6688556c11ef3563ea
https://pubmed.ncbi.nlm.nih.gov/28043946
https://pubmed.ncbi.nlm.nih.gov/28043946
Autor:
K. Jacobs, Ha Thi Nguyen, Mieke Geens, Catherine Staessen, Afroditi Mertzanidou, Claudia Spits
Publikováno v:
Vrije Universiteit Brussel
Current knowledge on chromosomal mosaicism in human cell cultures is mostly based on cytogenetic banding methods. The recent development of high-resolution full-genome analysis methods applicable to single cells is providing new insights into genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d587e19e324851ad7217f93f75c9e3
https://pubmed.ncbi.nlm.nih.gov/24970340
https://pubmed.ncbi.nlm.nih.gov/24970340
Autor:
Ha Nguyen Thi, Mieke Geens, Afroditi Mertzanidou, Kurt Jacobs, Carlo Heirman, Karine Breckpot, Claudia Spits
Publikováno v:
Vrije Universiteit Brussel
Gain of 20q11.21 is a chromosomal abnormality that is recurrently found in human pluripotent stem cells and cancers, strongly suggesting that this mutation confers a proliferative or survival advantage to these cells. In this work we studied three hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4a3e93df530cbb87d726720486581806
https://researchportal.vub.be/en/publications/8f7b6676-a4f6-476c-b349-b5ad8548a8b8
https://researchportal.vub.be/en/publications/8f7b6676-a4f6-476c-b349-b5ad8548a8b8
Autor:
Evelyne Vanneste, Leeanda Wilton, Afroditi Mertzanidou, Yves Moreau, Joris Vermeesch, Jiqiu Cheng, Karen Sermon, Claudia Spits
Publikováno v:
Vrije Universiteit Brussel
STUDY QUESTION What are the aneuploidy rates and incidence of mosaicism in good-quality human preimplantation embryos. SUMMARY ANSWER High-level mosaicism and structural aberrations are not restricted to arrested or poorly developing embryos but are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3b8506b638319e226f31c2e765611cd
https://researchportal.vub.be/en/publications/6bae0422-58b1-4a00-8ac7-7ec19f836e1c
https://researchportal.vub.be/en/publications/6bae0422-58b1-4a00-8ac7-7ec19f836e1c
Autor:
Ileana Mateizel, Claudia Spits, Afroditi Mertzanidou, A. Verloes, Karen Sermon, Ingeborg Liebaers
Publikováno v:
Vrije Universiteit Brussel
BACKGROUND: The presence of chromosomal abnormalities could have a negative impact for human embryonic stem cell (hESC) applications both in regenerative medicine and in research. A biomarker that allows the identification of chromosomal abnormalitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb1d75e2116346ed25f2f675c6b87bf
https://researchportal.vub.be/en/publications/3f26cc4b-d70f-4991-a7bd-31f555ef989b
https://researchportal.vub.be/en/publications/3f26cc4b-d70f-4991-a7bd-31f555ef989b
Autor:
Mieke Geens, Yves Vandeskelde, Josiane Van der Elst, Catherine Staessen, Afroditi Mertzanidou, Ileana Mateizel, Claudia Spits, Inge Liebaers, Karen Sermon
Publikováno v:
Vrije Universiteit Brussel
Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22706b97842fd12e0203da4fe49c33fc
https://researchportal.vub.be/en/publications/6a25b390-c2a5-4b57-b929-eaa817b78054
https://researchportal.vub.be/en/publications/6a25b390-c2a5-4b57-b929-eaa817b78054