Searching for the roots of the first free African American community

Autor: Leonor Gusmão, Masinda Nguidi, Javier Marrugo, Elizeu Fagundes de Carvalho, Verónica Gomes, Filipa Simão, Beatriz Martínez, António Amorim

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports

San Basilio de Palenque is an Afro-descendant community near Cartagena, Colombia, founded in the sixteenth century. The recognition of the historical and cultural importance of Palenque has promoted several studies, namely concerning the African root

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be0b4c20318b8baada5677000413c05
http://link.springer.com/article/10.1038/s41598-020-77608-8

Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31

Autor: Ruth J. F. Loos, Jennifer A. Smith, C. Charles Gu, Wei Zhao, Yingchang Lu, Sharon L.R. Kardia, Aravinda Chakravarti, Erin B. Ware, Priyanka Nandakumar, Fasil Tekola-Ayele, Dabeeru C. Rao, Charles N. Rotimi, Donna K. Arnett, Todd L. Edwards, Myriam Fornage, Heming Wang, Xiuqing Guo, Jie Yao, Xiaofeng Zhu, Richard S. Cooper, Jacklyn N. Hellwege, Bamidele O. Tayo, Georg Ehret

Publikováno v: European Journal of Human Genetics, Vol. 27, No 2 (2019) pp. 269-277

High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD) and is more prevalent in African Americans as compared to other US groups. Although large, population-based genome-wide association studies (GWAS) have identified over 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d05f2072fe57faa792ece8837069df5
https://archive-ouverte.unige.ch/unige:135503

Fine Mapping and Identification of BMI Loci in African Americans

Autor: Barbara Cochrane, Rebecca D. Jackson, Tara C. Matise, Khanh-Dung H. Nguyen, Cora E. Lewis, Jeffrey Haessler, Marguerite R. Irvin, Stephanie A. Rosse, Jian Gong, Denise K. Houston, C. Charles Gu, Richard S. Cooper, Dana C. Crawford, Jay H. Fowke, Pamela J. Schreiner, Lindsay Fernández-Rhodes, Iona Cheng, Charles Kooperberg, Steven Buyske, Brian E. Henderson, Ulrike Peters, Misa Graff, Loreall Pooler, Christopher A. Haiman, Robert Goodloe, Petra Bůžková, Holli H. Dilks, Jonathan Boston, Kari E. North, Nathan Pankratz, Georg Ehret, Myron D. Gross, James S. Pankow, Myriam Fornage, Marylyn D. Ritchie, Mark Leppert, Eric Boerwinkle, Unhee Lim, Lynne R. Wilkens, Loic Le Marchand, Christopher S. Carlson, Lew Kuller, Fredrick R. Schumacher, Eric Farber-Eger, Rongling Li, Lucia A. Hindorff

Publikováno v: American Journal of Human Genetics, Vol. 93, No 4 (2013) pp. 661-71

Genome-wide association studies (GWASs) primarily performed in European-ancestry (EA) populations have identified numerous loci associated with body mass index (BMI). However, it is still unclear whether these GWAS loci can be generalized to other et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2c9d27ecbd1933ab8f9519e087dd38
https://doi.org/10.1016/j.ajhg.2013.08.012

Influence of HLA-C expression level on HIV control

Autor: Richard Apps, Simon Mallal, Zabrina L. Brumme, Kelly A. Soderberg, Chanson J. Brumme, Ashley Moffett, Nelson L. Michael, Xue Zeng, James J. Goedert, Steven M. Wolinsky, Jonathan M. Carlson, Greg Q. Del Prete, Haoyan Chen, M. Anthony Moody, Yuko Yuki, Mina John, Susan Buchbinder, Jingyuan Fang, Gregory D. Kirk, Amy C. Weintrob, Steven G. Deeks, Florencia Pereyra, Xiaojiang Gao, Ronald J. Bosch, Thomas N. Denny, Jacques Fellay, Wilson Liao, George W. Nelson, Philip J. R. Goulder, Judy L. Stein, David Heckerman, Rasmi Thomas, Paul J. McLaren, Ying Qi, Jeffrey D. Lifson, Bruce D. Walker, Mary Carrington

Publikováno v: Science, vol. 340, no. 6128, pp. 87-91
Science (New York, N.Y.), vol 340, iss 6128

Thwarting HIV Multiple genome-wide association studies have revealed that human leukocyte antigen (HLA) genes of the major histocompatibility complex locus have the strongest impact on HIV. In particular, a single-nucleotide polymorphism 35 base pair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9f631ad271b89170e5d18f3042deb5
https://ora.ox.ac.uk/objects/uuid:91e91a3a-bc20-4503-948e-488edc324579

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

Autor: Palmer, Nicholette D, McDonough, Caitrin W, Hicks, Pamela J, Roh, Bong H, Wing, Maria R, An, S Sandy, Hester, Jessica M, Cooke, Jessica N, Bostrom, Meredith A, Rudock, Megan E, Talbert, Matthew E, Lewis, Joshua P, DIAGRAM Consortium, MAGIC Investigators, Ferrara, Assiamira, Lu, Lingyi, Ziegler, Julie T, Sale, Michele M, Divers, Jasmin, Shriner, Daniel, Adeyemo, Adebowale, Rotimi, Charles N, Ng, Maggie CY, Langefeld, Carl D, Freedman, Barry I, Bowden, Donald W, Voight, Benjamin F, Scott, Laura J, Steinthorsdottir, Valgerdur, Morris, Andrew P, Dina, Christian, Welch, Ryan P, Zeggini, Eleftheria, Huth, Cornelia, Aulchenko, Yurii S, Thorleifsson, Gudmar, McCulloch, Laura J, Ferreira, Teresa, Grallert, Harald, Amin, Najaf, Wu, Guanming, Willer, Cristen J, Raychaudhuri, Soumya, McCarroll, Steve A, Langenberg, Claudia, Hofmann, Oliver M, Dupuis, Josée, Qi, Lu, Segrè, Ayellet V, Van Hoek, Mandy, Navarro, Pau, Ardlie, Kristin, Balkau, Beverley, Benediktsson, Rafn, Bennett, Amanda J, Blagieva, Roza, Boerwinkle, Eric, Bonnycastle, Lori L, Boström, Kristina Bengtsson, Bravenboer, Bert, Bumpstead, Suzannah, Burtt, Noël P, Charpentier, Guillaume, Chines, Peter S, Cornelis, Marilyn, Couper, David J, Crawford, Gabe, Doney, Alex SF, Elliott, Katherine S, Elliott, Amanda L, Erdos, Michael R, Fox, Caroline S, Franklin, Christopher S, Ganser, Martha, Gieger, Christian, Grarup, Niels, Green, Todd, Griffin, Simon, Groves, Christopher J, Guiducci, Candace, Hadjadj, Samy, Hassanali, Neelam, Herder, Christian, Isomaa, Bo, Jackson, Anne U, Johnson, Paul RV, Jørgensen, Torben, Kao, Wen HL, Klopp, Norman, Kong, Augustine, Kraft, Peter, Kuusisto, Johanna, Lauritzen, Torsten, Li, Man, Lieverse, Aloysius, Lindgren, Cecilia M, Lyssenko, Valeriya, Marre, Michel, Meitinger, Thomas, Midthjell, Kristian, Morken, Mario A, Narisu, Narisu, Nilsson, Peter, Owen, Katharine R, Payne, Felicity, Perry, John RB, Petersen, Ann-Kristin, Platou, Carl, Proença, Christine, Prokopenko, Inga, Rathmann, Wolfgang, Rayner, N William, Robertson, Neil R, Rocheleau, Ghislain, Roden, Michael, Sampson, Michael J, Saxena, Richa, Shields, Beverley M, Shrader, Peter, Sigurdsson, Gunnar, Sparsø, Thomas, Strassburger, Klaus, Stringham, Heather M, Sun, Qi, Swift, Amy J, Thorand, Barbara, Tichet, Jean, Tuomi, Tiinamaija, Van Dam, Rob M, Van Haeften, Timon W, Van Herpt, Thijs, Van Vliet-Ostaptchouk, Jana V, Walters, G Bragi, Weedon, Michael N, Wijmenga, Cisca, Witteman, Jacqueline, Bergman, Richard N, Cauchi, Stephane, Collins, Francis S, Gloyn, Anna L, Gyllensten, Ulf, Hansen, Torben, Hide, Winston A, Hitman, Graham A, Hofman, Albert, Hunter, David J, Hveem, Kristian, Laakso, Markku, Mohlke, Karen L, Morris, Andrew D, Palmer, Colin NA, Pramstaller, Peter P, Rudan, Igor, Sijbrands, Eric, Stein, Lincoln D, Tuomilehto, Jaakko, Uitterlinden, Andre, Walker, Mark, Wareham, Nicholas J, Watanabe, Richard M, Abecasis, Goncalo R, Boehm, Bernhard O, Campbell, Harry, Daly, Mark J, Hattersley, Andrew T, Hu, Frank B, Meigs, James B, Pankow, James S, Pedersen, Oluf, Wichmann, H-Erich, Barroso, Inês, Florez, Jose C, Frayling, Timothy M, Groop, Leif, Sladek, Rob, Thorsteinsdottir, Unnur, Wilson, James F, Illig, Thomas, Froguel, Philippe, Van Duijn, Cornelia M, Stefansson, Kari, Altshuler, David, Boehnke, Michael, McCarthy, Mark I, Soranzo, Nicole, Wheeler, Eleanor, Glazer, Nicole L, Bouatia-Naji, Nabila, Mägi, Reedik, Randall, Joshua, Johnson, Toby, Elliott, Paul, Rybin, Denis, Henneman, Peter, Dehghan, Abbas, Hottenga, Jouke Jan, Song, Kijoung, Goel, Anuj, Egan, Josephine M, Lajunen, Taina, Doney, Alex, Kanoni, Stavroula, Cavalcanti-Proença, Christine, Kumari, Meena, Timpson, Nicholas J, Zabena, Carina, Ingelsson, Erik, An, Ping, O'Connell, Jeffrey, Luan, Jian'an, Elliott, Amanda, McCarroll, Steven A, Roccasecca, Rosa Maria, Pattou, François, Sethupathy, Praveen, Ariyurek, Yavuz, Barter, Philip, Beilby, John P, Ben-Shlomo, Yoav, Bergmann, Sven, Bochud, Murielle, Bonnefond, Amélie, Borch-Johnsen, Knut, Böttcher, Yvonne, Brunner, Eric, Bumpstead, Suzannah J, Chen, Yii-Der Ida, Chines, Peter, Clarke, Robert, Coin, Lachlan JM, Cooper, Matthew N, Crisponi, Laura, Day, Ian NM, De Geus, Eco JC, Delplanque, Jerome, Fedson, Annette C, Fischer-Rosinsky, Antje, Forouhi, Nita G, Frants, Rune, Franzosi, Maria Grazia, Galan, Pilar, Goodarzi, Mark O, Graessler, Jürgen, Grundy, Scott, Gwilliam, Rhian, Hallmans, Göran, Hammond, Naomi, Han, Xijing, Hartikainen, Anna-Liisa, Hayward, Caroline, Heath, Simon C, Hercberg, Serge, Hicks, Andrew A, Hillman, David R, Hingorani, Aroon D, Hui, Jennie, Hung, Joe, Jula, Antti, Kaakinen, Marika, Kaprio, Jaakko, Kesaniemi, Y Antero, Kivimaki, Mika, Knight, Beatrice, Koskinen, Seppo, Kovacs, Peter, Kyvik, Kirsten Ohm, Lathrop, G Mark, Lawlor, Debbie A, Le Bacquer, Olivier, Lecoeur, Cécile, Li, Yun, Mahley, Robert, Mangino, Massimo, Manning, Alisa K, Martínez-Larrad, María Teresa, McAteer, Jarred B, McPherson, Ruth, Meisinger, Christa, Melzer, David, Meyre, David, Mitchell, Braxton D, Mukherjee, Sutapa, Naitza, Silvia, Neville, Matthew J, Oostra, Ben A, Orrù, Marco, Pakyz, Ruth, Paolisso, Giuseppe, Pattaro, Cristian, Pearson, Daniel, Peden, John F, Pedersen, Nancy L, Perola, Markus, Pfeiffer, Andreas FH, Pichler, Irene, Polasek, Ozren, Posthuma, Danielle, Potter, Simon C, Pouta, Anneli, Province, Michael A, Psaty, Bruce M, Rayner, Nigel W, Rice, Kenneth, Ripatti, Samuli, Rivadeneira, Fernando, Rolandsson, Olov, Sandbaek, Annelli, Sandhu, Manjinder, Sanna, Serena, Sayer, Avan Aihie, Scheet, Paul, Seedorf, Udo, Sharp, Stephen J, Shields, Beverley, Sijbrands, Eric JG, Silveira, Angela, Simpson, Laila, Singleton, Andrew, Smith, Nicholas L, Sovio, Ulla, Swift, Amy, Syddall, Holly, Syvänen, Ann-Christine, Tanaka, Toshiko, Tönjes, Anke, Uitterlinden, André G, Van Dijk, Ko Willems, Varma, Dhiraj, Visvikis-Siest, Sophie, Vitart, Veronique, Vogelzangs, Nicole, Waeber, Gérard, Wagner, Peter J, Walley, Andrew, Ward, Kim L, Watkins, Hugh, Wild, Sarah H, Willemsen, Gonneke, Witteman, Jaqueline CM, Yarnell, John WG, Zelenika, Diana, Zethelius, Björn, Zhai, Guangju, Zhao, Jing Hua, Zillikens, M Carola, Borecki, Ingrid B, Loos, Ruth JF, Meneton, Pierre, Magnusson, Patrik KE, Nathan, David M, Williams, Gordon H, Silander, Kaisa, Salomaa, Veikko, Smith, George Davey, Bornstein, Stefan R, Schwarz, Peter, Spranger, Joachim, Karpe, Fredrik, Shuldiner, Alan R, Cooper, Cyrus, Dedoussis, George V, Serrano-Ríos, Manuel, Lind, Lars, Palmer, Lyle J, Franks, Paul W, Ebrahim, Shah, Marmot, Michael, Kao, WH Linda, Pramstaller, Peter Paul, Wright, Alan F, Stumvoll, Michael, Hamsten, Anders, Buchanan, Thomas A, Valle, Timo T, Rotter, Jerome I, Siscovick, David S, Penninx, Brenda WJH, Boomsma, Dorret I, Deloukas, Panos, Spector, Timothy D, Ferrucci, Luigi, Cao, Antonio, Scuteri, Angelo, Schlessinger, David, Uda, Manuela, Ruokonen, Aimo, Jarvelin, Marjo-Riitta, Waterworth, Dawn M, Vollenweider, Peter, Peltonen, Leena, Mooser, Vincent, Sladek, Robert

Publikováno v: PLoS ONE, 7(1):e29202. PUBLIC LIBRARY SCIENCE
Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, Sandy An, S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Posthuma, D, Penninx, B W J H & Sladek, R 2012, ' A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202
PLoS ONE, Vol 7, Iss 1, p e29202 (2012)
PLoS ONE, 7(1)
PLoS ONE
PLoS ONE, 7(1):e29202. Public Library of Science
PLoS ONE 7:e29202 (2012)
DIAGRAM Consortium & MAGIC Investigators 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', P L o S One, vol. 7, no. 1, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202
Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, An, S S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L J, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Navarro, P, Rudan, I, Campbell, H, Wilson, J F, Hayward, C, Vitart, V & Wild, S H & Wright, A F 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202, pp. 1-14 . https://doi.org/10.1371/journal.pone.0029202
Palmer, N D, McDonough, C W, Hicks, P J, Roh, B H, Wing, M R, An, S S, Hester, J M, Cooke, J N, Bostrom, M A, Rudock, M E, Talbert, M E, Lewis, J P, Ferrara, A, Lu, L, Ziegler, J T, Sale, M M, Divers, J, Shriner, D, Adeyemo, A, Rotimi, C N, Ng, M C Y, Langefeld, C D, Freedman, B I, Bowden, D W, Voight, B F, Scott, L J, Steinthorsdottir, V, Morris, A P, Dina, C, Welch, R P, Zeggini, E, Huth, C, Aulchenko, Y S, Thorleifsson, G, McCulloch, L J, Ferreira, T, Grallert, H, Amin, N, Wu, G, Willer, C J, Raychaudhuri, S, McCarroll, S A, Langenberg, C, Hofmann, O M, Dupuis, J, Qi, L, Segrè, A V, van Hoek, M, Borch-Johnsen, K, Kyvik, K O & DIAGRAM Consortium 2012, ' A genome-wide association search for type 2 diabetes genes in African Americans ', P L o S One, vol. 7, no. 1, pp. e29202 . https://doi.org/10.1371/journal.pone.0029202
PLOS ONE
Plos One, vol. 7, no. 1, pp. e29202
PLoS ONE; Vol 7
Yarnell, J & Palmer, N D 2012, ' A Genome-wide association search for Type 2 Diabetes genes in African Americans ', PLoS ONE, vol. 7, no. 1, e29202 . https://doi.org/10.1371/journal.pone.0029202

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373ffe21cfe482b2e100586455896d9e
https://research.rug.nl/en/publications/4fbcdf97-a239-44a7-9038-6f4d3c2df849