Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Afrand Kamali"'
Autor:
O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7d56b0bf0e605a39ee70fc897c8b59
https://doi.org/10.1158/1535-7163.c.6542328.v1
https://doi.org/10.1158/1535-7163.c.6542328.v1
Autor:
O. Petter Veiby, Jennifer Fretland, Mark G. Qian, Jayaprakasam Bolleddula, Robbie Robertson, Maria Borland, Melissa Saylor Landen, Cindy Q. Xia, Andy Zhu, Secil Koseoglu, Kurt Eng, Afrand Kamali, Bradley Stringer, Thomas A. Keating, Katharine C. Lai, Michael D. Smith, Michelle L. Ganno, Bret M. Bannerman, Melissa Gallery, Donna Cvet, Adnan O. Abu-Yousif
Supplemental Figure 1: heavy and light chain sequences for 5F9, the human IgG1 monoclonal antibody (mAb) targeting the extracellular domain of GCC as described previously Supplemental Figure 2: Characterization of TAK-164 and chKTI-DGN549 by A) SDS P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc671e1a3ed72f6591ec22f46838181
https://doi.org/10.1158/1535-7163.22519161.v1
https://doi.org/10.1158/1535-7163.22519161.v1
Autor:
Bradley Stringer, Kurt Eng, Katharine C. Lai, Mark G. Qian, Jennifer Fretland, Melissa Gallery, Robbie Robertson, Melissa Saylor Landen, Cindy Q. Xia, Adnan O. Abu-Yousif, O. Petter Veiby, Afrand Kamali, Maria Borland, Secil Koseoglu, Bret Bannerman, Andy Z. X. Zhu, Michelle L. Ganno, Thomas A. Keating, Michael D. Smith, Donna Cvet, Jayaprakasam Bolleddula
Publikováno v:
Molecular Cancer Therapeutics. 19:2079-2088
Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is a
Autor:
Afrand Kamali, Mohammad Shadid, Michael D. Smith, Jayaprakasam Bolleddula, Abhi Shah, Swapan Chowdhury
Publikováno v:
Drug Metabolism and Disposition. 48:1239-1245
TAK-164 is an antibody-drug conjugate (ADC) comprising human anti-guanylyl cyclase C (GCC) monoclonal antibody conjugated to indolinobenzodiazepine DNA alkylator IGN-P1 through a cleavable alanine-alanine dipeptide linker. TAK-164 is currently being
Autor:
Afrand Kamali, Mark G. Qian, Kojo Abdul-Hadi, Adnan O. Abu-Yousif, Linlin Dong, Susan Chen, Hiroshi Sugimoto, Chao Li
Publikováno v:
Analytical Biochemistry. 568:1-6
Highly potent DNA damaging agents have become a key class of toxins for antibody-drug conjugate (ADC) based targeted therapy. However, until recently, no quantitative bioanalytical method was available to measure the toxin in the form of DNA adducts.
Autor:
Jayaprakasam, Bolleddula, Abhi, Shah, Mohammad, Shadid, Afrand, Kamali, Michael D, Smith, Swapan K, Chowdhury
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(11)
TAK-164 is an antibody-drug conjugate (ADC) comprising human anti-guanylyl cyclase C (GCC) monoclonal antibody conjugated to indolinobenzodiazepine DNA alkylator IGN-P1 through a cleavable alanine-alanine dipeptide linker. TAK-164 is currently being
Autor:
Swapan K. Chowdhury, Cindy Q. Xia, Jayaprakasam Bolleddula, Afrand Kamali, Mohammad Shadid, Adnan O. Abu-Yousif, Michael Smith, Abhi Shah
Publikováno v:
Drug Metabolism and Pharmacokinetics. 34:S20-S21
Autor:
Cindy Q. Xia, Afrand Kamali, Mark G. Qian, Bradley Stringer, Thomas A. Keating, Kurt Eng, Michelle L. Ganno, Michael D. Smith, Secil Koseoglu, Bret Bannerman, O. Petter Veiby, Jayaprakasam Bolleddula, Katharine C. Lai, Donna Cvet, Melissa Gallery, Adnan O. Abu-Yousif
Publikováno v:
Molecular Cancer Therapeutics. 17:B120-B120
TAK-164 is an antibody-drug conjugate comprising a full-length, fully human IgG1 monoclonal antibody (mAb) directed towards the extracellular domain of guanylyl cyclase C (GCC). The mAb is conjugated using the peptide-linked indolino-benzodiazepine D
Publikováno v:
Analytical chemistry. 82(5)
Desorption electrospray ionization (DESI) directly analyzes soluble chemical components present on surfaces when a pneumatically assisted electrospray is directed at the sample. Here we demonstrate that the same spray desorption mechanism that operat
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