Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Afrah Sattikar"'
Publikováno v:
SLAS Discovery. 24:332-345
Building, curating, and maintaining a compound collection is an expensive operation, beyond the scope of most academic organizations. Here we describe the selection criteria used to compile the LifeArc diversity set from commercial suppliers and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fafcdbb964a1a387c2623dfaed517d4
https://doi.org/10.1177/2472555218803696
https://doi.org/10.1177/2472555218803696
Autor:
Elizabeth A. Love, Vijay Chudasama, Richard J Spears, James R. Baker, Peter A. Szijj, Archie Wall, Calise Bahou, Faiza Javaid, Afrah Sattikar
Publikováno v:
Bioconjugate Chemistry
Linkers that enable the site-selective synthesis of chemically modified proteins are of great interest to the field of chemical biology. Homogenous bioconjugates often show advantageous pharmacokinetic profiles and consequently increased efficacy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26456f6a34f2dc26e54e4034ac095632
https://pubmed.ncbi.nlm.nih.gov/33710874
https://pubmed.ncbi.nlm.nih.gov/33710874
Autor:
Elizabeth A. Love, Seema Patel, Andy Merritt, Kevin J. Gillen, Hannah Cook, Jonathan M. Large, David Matthews, Afrah Sattikar
Publikováno v:
Chembiochem
Antibody–drug conjugates (ADCs) are a growing class of therapeutics that harness the specificity of antibodies and the cell‐killing potency of small‐molecule drugs. Beyond cytotoxics, there are few examples of the application of an ADC approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3414066faed913c39e74b04b137003
https://pubmed.ncbi.nlm.nih.gov/30507063
https://pubmed.ncbi.nlm.nih.gov/30507063
Autor:
Neil McGuiness, Craig Stamp, Mark R Dowling, Florian Mullershausen, Steven J. Charlton, Darren Riddy, Afrah Sattikar, David A. Sykes, Danilo Guerini, Ines Rodrigues, Michelle Bradley, Albrecht Glaenzel
Publikováno v:
British Journal of Pharmacology. 171:4797-4807
Background and Purpose The molecular mechanism underlying the clinical efficacy of FTY720-P is thought to involve persistent internalization and enhanced degradation of the S1P1 receptor subtype (S1P1R). We have investigated whether receptor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1edb2ffc3a96566b0c3838b5631d9e
https://doi.org/10.1111/bph.12620
https://doi.org/10.1111/bph.12620
Publikováno v:
British journal of pharmacology. 174(3)
Human lung fibroblasts (HLF) express high levels of the LPAHere, we have explored the signalling profiles of a range of LPA analogues in HLF that endogenously express the LPAThese analyses demonstrated that the 16:0, 17:0, 18:2 and C18:1 LPA analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f2a4ad48ca5342cf4567d51320fa932
https://pubmed.ncbi.nlm.nih.gov/27864940
https://pubmed.ncbi.nlm.nih.gov/27864940
Autor:
Steven J. Charlton, Emilie Renard, Alexandre Trifilieff, Karolina Gherbi, David A. Sykes, Michelle Bradley, Robin Alec Fairhurst, Afrah Sattikar, Elizabeth M. Rosethorne, John D Wright
Publikováno v:
Molecular pharmacology. 89(4)
Super agonists produce greater functional responses than endogenous agonists in the same assay, and their unique pharmacology is the subject of increasing interest and debate. We propose that receptor residence time and the duration of receptor signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ab976fff1a2f827a5588f396475ef2
https://pubmed.ncbi.nlm.nih.gov/26772612
https://pubmed.ncbi.nlm.nih.gov/26772612
Autor:
David A, Sykes, Darren M, Riddy, Craig, Stamp, Michelle E, Bradley, Neil, McGuiness, Afrah, Sattikar, Danilo, Guerini, Ines, Rodrigues, Albrecht, Glaenzel, Mark R, Dowling, Florian, Mullershausen, Steven J, Charlton
Publikováno v:
British journal of pharmacology. 171(21)
The molecular mechanism underlying the clinical efficacy of FTY720-P is thought to involve persistent internalization and enhanced degradation of the S1P1 receptor subtype (S1P1R). We have investigated whether receptor binding kinetics and β-arresti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8242a0923714a73fea557d6fb0ed1101
https://pubmed.ncbi.nlm.nih.gov/24641481
https://pubmed.ncbi.nlm.nih.gov/24641481
Publikováno v:
Journal of laboratory automation. 18(4)
The accurate transfer of biological reagents represents a fundamental step in the drug screening process, and the elimination of carryover is critical for the generation of accurate measurements of biological activity. The introduction of automated l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618bc688966107f78a7672d6a4b6805d
https://pubmed.ncbi.nlm.nih.gov/22983566
https://pubmed.ncbi.nlm.nih.gov/22983566