Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Afnan I Shahin"'
1
Akademický článek
Design and synthesis of novel anti-urease imidazothiazole derivatives with promising antibacterial activity against Helicobacter pylori.
Autor: Afnan I Shahin, Sumera Zaib, Seyed-Omar Zaraei, Reena A Kedia, Hanan S Anbar, Muhammad Tayyab Younas, Taleb H Al-Tel, Ghalia Khoder, Mohammed I El-Gamal
Publikováno v: PLoS ONE, Vol 18, Iss 6, p e0286684 (2023)
Urease enzyme is a known therapeutic drug target for treatment of Helicobacter pylori infection due to its role in settlement and growth in gastric mucosa. In this study, we designed a new series of sulfonates and sulfamates bearing imidazo[2,1-b]thi
Externí odkaz: https://doaj.org/article/372376a6401b4ec889609a24fcb81cff
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6
Akademický článek
A Review of HER4 (ErbB4) Kinase, Its Impact on Cancer, and Its Inhibitors
Autor: Mohammed I. El-Gamal, Nada H. Mewafi, Nada E. Abdelmotteleb, Minnatullah A. Emara, Hamadeh Tarazi, Rawan M. Sbenati, Moustafa M. Madkour, Seyed-Omar Zaraei, Afnan I. Shahin, Hanan S. Anbar
Publikováno v: Molecules, Vol 26, Iss 23, p 7376 (2021)
HER4 is a receptor tyrosine kinase that is required for the evolution of normal body systems such as cardiovascular, nervous, and endocrine systems, especially the mammary glands. It is activated through ligand binding and activates MAPKs and PI3K/AK
Externí odkaz: https://doaj.org/article/d1f5ef7d0e5a4d4385bbf9fe1aeff7c2
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7
Design and synthesis of new adamantyl derivatives as promising antiproliferative agents
Autor: Afnan I. Shahin, Seyed-Omar Zaraei, Bilal O. AlKubaisi, Saif Ullah, Hanan S. Anbar, Randa El-Gamal, Varsha Menon, Mohammed S. Abdel-Maksoud, Chang-Hyun Oh, Raafat El-Awady, Nicolly Espindola Gelsleichter, Julie Pelletier, Jean Sévigny, Jamshed Iqbal, Taleb H. Al-Tel, Mohammed I. El-Gamal
Publikováno v: European journal of medicinal chemistry. 246
A series of adamantyl carboxamide derivatives containing sulfonate or sulfonamide moiety were designed as multitargeted inhibitors of ectonucleotide pyrophosphatases/phosphodiesterases (NPPs) and carbonic anhydrases (CAs). The target compounds were i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b1b3f97ea808b369676da065d63724
https://pubmed.ncbi.nlm.nih.gov/36470105
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8
Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity
Autor: Seyed-Omar Zaraei, Nour N. Al-Ach, Hanan S. Anbar, Randa El-Gamal, Hamadeh Tarazi, Rimas T. Tokatly, Rawan R. Kalla, Mouna A. Munther, Marwa M. Wahba, Aya M. Alshihabi, Mahmoud K. Shehata, Rawan M. Sbenati, Afnan I. Shahin, Raafat El-Awady, Taleb H. Al-Tel, Mohammed I. El-Gamal
Publikováno v: European Journal of Medicinal Chemistry. 238:114434
This article describes the design, synthesis, and biological screening of a new series of diarylurea and diarylamide derivatives including quinoline core armed with dimethylamino or morpholino side chain. Fifteen target compounds were selected by the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f699c7ec32b7f1325ad87dba4547a338
https://doi.org/10.1016/j.ejmech.2022.114434
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