Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Afnan Abu-Thuraia"'
Autor:
Marco Biondini, Camille Lehuédé, Sébastien Tabariès, Matthew G. Annis, Alain Pacis, Eric H. Ma, Christine Tam, Brian E. Hsu, Yannick Audet-Delage, Afnan Abu-Thuraia, Charlotte Girondel, Valerie Sabourin, Stephanie P. Totten, Mariana de Sá Tavares Russo, Gaëlle Bridon, Daina Avizonis, Marie-Christine Guiot, Julie St-Pierre, Josie Ursini-Siegel, Russell Jones, Peter M. Siegel
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103276- (2024)
Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet little is known regarding how cancer cells modify their acquired metabolic programs in response to different metastatic microenvironments. We have previously
Externí odkaz:
https://doaj.org/article/9541bdda466b464aac43f308bd0b1d8e
Autor:
Leifu Chang, Jing Yang, Chang Hwa Jo, Andreas Boland, Ziguo Zhang, Stephen H. McLaughlin, Afnan Abu-Thuraia, Ryan C. Killoran, Matthew J. Smith, Jean-Francois Côté, David Barford
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
DOCK2 is a guanine nucleotide exchange factor (GEF) that activates RHO GTPases and interacts with ELMO1, which stimulates its GEF activity. Here, the authors provide mechanistic insights into how ELMO1 regulates DOCK2 activity by determining the stru
Externí odkaz:
https://doaj.org/article/d8a372772f44414b8c28c69fb426524f
Autor:
Afnan Abu-Thuraia, Marie-Anne Goyette, Jonathan Boulais, Carine Delliaux, Chloé Apcher, Céline Schott, Rony Chidiac, Halil Bagci, Marie-Pier Thibault, Dominique Davidson, Mathieu Ferron, André Veillette, Roger J. Daly, Anne-Claude Gingras, Jean-Philippe Gratton, Jean-François Côté
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastas
Externí odkaz:
https://doaj.org/article/379ed28905e54ed3848a111bf0a70d33
Publikováno v:
International Journal of Cell Biology, Vol 2012 (2012)
Actin cytoskeleton remodeling is under the regulation of multiple proteins with various activities. Here, we demonstrate that the γ2 isoform of Casein Kinase I (CKIγ2) is part of a novel molecular path regulating the formation of actin stress fiber
Externí odkaz:
https://doaj.org/article/c394817f98c742f99edd062758c2aa38
Autor:
David Barford, Chang Hwa Jo, Matthew J. Smith, Ziguo Zhang, Jean-François Côté, Stephen H. McLaughlin, Jing Yang, Andreas Boland, Afnan Abu-Thuraia, Leifu Chang, Ryan C. Killoran
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Funder: Gouvernement du Canada | Instituts de Recherche en Santé du Canada | CIHR Skin Research Training Centre (Skin Research Training Centre); doi: https://doi.org/10.13039/501100007202
Funder: Canadian Network for Research and Innovation in
Funder: Canadian Network for Research and Innovation in
Autor:
Rémi Laflamme, Frédérick A. Mallette, Severine Leclerc, Florian Sennlaub, Christina Sawchyn, Roberto Diaz-Marin, Gael Cagnone, Masayuki Hata, Flavio A. Rezende, Mathieu Neault, Jean-Sébastien Joyal, Ariel M. Wilson, Vera Guber, Agnieszka Dejda, Joel P. Howard, Przemyslaw Sapieha, Sergio Crespo-Garcia, Afnan Abu-Thuraia, Francois Binet, Jean-François Côté, Célia Parinot, Rachel Juneau, Gaelle Mawambo, Frédérique Pilon, Karine Boulay, Gregor Andelfinger, Manuel Buscarlet
Publikováno v:
Science. 369
In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening c
Autor:
Jean-François Côté, Daniel Figeys, Stéphanie Duval, Deeptee Seebun, Janice Mayne, Islam E. Elkholi, Nabil G. Seidah, Rui Chen, Afnan Abu-Thuraia
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 8, Pp 1-15 (2020)
Cell Death and Disease, Vol 11, Iss 8, Pp 1-15 (2020)
The proprotein convertases (PCs) are responsible for the maturation of precursor proteins, and are involved in multiple and critical biological processes. Over the past 30 years, the PCs have had great translational applications, but the physiologica
Autor:
Rony Chidiac, Afnan Abu-Thuraia, Jean-Philippe Gratton, Robert A. Screaton, Yoshinori Fukui, Rosemarie Gauthier, Jean-François Côté
Publikováno v:
Molecular and Cellular Biology. 35:76-87
The receptor tyrosine kinase Axl contributes to cell migration and invasion. Expression of Axl correlates with metastatic progression in cancer patients, yet the specific signaling events promoting invasion downstream of Axl are poorly defined. Herei
Publikováno v:
International Journal of Cell Biology
International Journal of Cell Biology, Vol 2012 (2012)
International Journal of Cell Biology, Vol 2012 (2012)
Actin cytoskeleton remodeling is under the regulation of multiple proteins with various activities. Here, we demonstrate that theγ2 isoform of Casein Kinase I (CKIγ2) is part of a novel molecular path regulating the formation of actin stress fibers
Autor:
Jean-François Côté, Rebecca Cusseddu, Jean-Philippe Gratton, Benjamin Haibe-Kains, Marie-Anne Goyette, Islam E. Elkholi, Afnan Abu-Thuraia, Nehme El-Hachem
Publikováno v:
Scopus-Elsevier
Oncotarget
Oncotarget
Triple-Negative Breast Cancer (TNBC) is an aggressive cancer subtype that is associated with a poor prognosis due to its propensity to form metastases. The receptor tyrosine kinase AXL plays a role in tumor cell dissemination and its expression in br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54a1ab3b1f84503a949c650c02845d4
http://www.scopus.com/inward/record.url?eid=2-s2.0-85063665632&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-85063665632&partnerID=MN8TOARS