Výsledky vyhledávání

Dissertation/ Thesis

Affitin-dendrimer conjugates for multivalency-enhanced targeting

Autor: Vukojicic, Petar

Les nanoparticules décorées de ligands de ciblage sont des dispositifs puissants développés pour servir d'outils théranostiques efficaces contre des maladies graves comme le cancer ou les maladies infectieuses. En raison des limitations importan

Externí odkaz: http://www.theses.fr/2019NANT1002/document

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Model Affitin and PEG modifications onto siRNA lipid nanocapsules: cell uptake and

Autor: Pauline, Resnier, Elise, Lepeltier, Anthea Lucrezia, Emina, Natacha, Galopin, Jérôme, Bejaud, Stephanie, David, Caroline, Ballet, Thierry, Benvegnu, Frédéric, Pecorari, Igor, Chourpa, Jean-Pierre, Benoit, Catherine, Passirani

Publikováno v: RSC advances. 9(47)

Malignant melanoma is an aggressive tumor, associated with the presence of local and/or distant metastases. The development of gene therapy by the use of small interfering RNA (siRNA) represents a promising new treatment. However, the protection of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::136c16a035bb76c7bd43c0454e011d79
https://pubmed.ncbi.nlm.nih.gov/35529231

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Akademický článek

Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation.

Autor: Garlich, Joshua¹ (AUTHOR) josh.garlich@apellis.com, Cinier, Mathieu² (AUTHOR) mathieu@affilogic.com, Chevrel, Anne² (AUTHOR) anne@affilogic.com, Perrocheau, Anaëlle² (AUTHOR) anaelle@affilogic.com, Eyerman, David J.¹ (AUTHOR) david.eyerman@apellis.com, Orme, Mark¹ (AUTHOR) mark.orme@apellis.com, Kitten, Olivier² (AUTHOR) olivier@affilogic.com, Scheibler, Lukas¹ (AUTHOR) lukas@apellis.com

Publikováno v: Biomolecules (2218-273X). Mar2022, Vol. 12 Issue 3, p432. 18p.

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Akademický článek

Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation

Autor: Joshua Garlich, Mathieu Cinier, Anne Chevrel, Anaëlle Perrocheau, David J. Eyerman, Mark Orme, Olivier Kitten, Lukas Scheibler

Publikováno v: Biomolecules, Vol 12, Iss 3, p 432 (2022)

Uncontrolled complement activation contributes to multiple immune pathologies. Although synthetic compstatin derivatives targeting C3 and C3b are robust inhibitors of complement activation, their physicochemical and molecular properties may limit acc

Externí odkaz: https://doaj.org/article/7819b32d28f843e9ba972b23178a3ce0

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Akademický článek

Artificial Affinity Proteins as Ligands of Immunoglobulins

Autor: Barbara Mouratou, Ghislaine Béhar, Frédéric Pecorari

Publikováno v: Biomolecules, Vol 5, Iss 1, Pp 60-75 (2015)

A number of natural proteins are known to have affinity and specificity for immunoglobulins. Some of them are widely used as reagents for detection or capture applications, such as Protein G and Protein A. However, these natural proteins have a defin

Externí odkaz: https://doaj.org/article/17597f96ac624438b4d9e654e1776edb

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Evaluation of docking procedures reliability in affitins-partners interactions

Autor: Anna Ranaudo, Ugo Cosentino, Claudio Greco, Giorgio Moro, Alessandro Bonardi, Alessandro Maiocchi, Elisabetta Moroni

Publikováno v: Frontiers in chemistry. 10

Affitins constitute a class of small proteins belonging to Sul7d family, which, in microorganisms such as Sulfolobus acidocaldarius, bind DNA preventing its denaturation. Thanks to their stability and small size (60–66 residues in length) they have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092161b256f5bd13504649acb491d94b
https://pubmed.ncbi.nlm.nih.gov/36531315

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Whole‐bacterium ribosome display selection for isolation of highly specific anti‐ Staphyloccocus aureus Affitins for detection‐ and capture‐based biomedical applications

Autor: Stanimir Kambarev, Ghislaine Béhar, Frédéric Pecorari, Axelle Renodon-Cornière, Petar Vukojicic, Stéphane Corvec, Nathalie Caroff, Barbara Mouratou

Publikováno v: Biotechnology and Bioengineering
Biotechnology and Bioengineering, 2019, Epub ahead of print. ⟨10.1002/bit.26989⟩
Biotechnology and Bioengineering, Wiley, 2019, Epub ahead of print. ⟨10.1002/bit.26989⟩

International audience; Detection and capture methods using antibodies have been developed to ensure identification of pathogens in biological samples. Though antibodies have many attractive properties, they also have limitations and there are needs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caebd519a6e1c8d40adcbc869d66ade3
https://doi.org/10.1002/bit.26989

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