Genetic variation associated with condensate dysregulation in disease.

Autor: Banani SF; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Afeyan LK; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Hawken SW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Program of Computational & Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Henninger JE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Dall'Agnese A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Clark VE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Platt JM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Oksuz O; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Hannett NM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Sagi I; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Lee TI; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: young@wi.mit.edu.

Publikováno v: Developmental cell [Dev Cell] 2022 Jul 25; Vol. 57 (14), pp. 1776-1788.e8. Date of Electronic Publication: 2022 Jul 08.

Predicting master transcription factors from pan-cancer expression data.

Autor: Reddy J; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Fonseca MAS; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Corona RI; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Nameki R; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Segato Dezem F; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Klein IA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Chang H; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Chaves-Moreira D; Penn Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA., Afeyan LK; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Malta TM; Henry Ford Hospital, Detroit, MI, USA., Lin X; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Abbasi F; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Font-Tello A; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Sabedot T; Henry Ford Hospital, Detroit, MI, USA., Cejas P; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Rodríguez-Malavé N; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Seo JH; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Lin DC; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Matulonis U; Division of Gynecologic Oncology, Dana Farber Cancer Institute, Boston, MA, USA., Karlan BY; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Cancer Population Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Gayther SA; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Pasaniuc B; Bioinformatics Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Computational Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Gusev A; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; McGraw/Patterson Center for Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Noushmehr H; Henry Ford Hospital, Detroit, MI, USA., Long H; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Freedman ML; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA.; The Eli and Edythe L. Broad Institute, Cambridge, MA, USA., Drapkin R; Penn Ovarian Cancer Research Center, University of Pennsylvania, Philadelphia, PA, USA., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, M.I.T., Cambridge, MA, USA., Abraham BJ; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Lawrenson K; Women's Cancer Research Program at the Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Center for Bioinformatics and Functional Genomics, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Publikováno v: Science advances [Sci Adv] 2021 Nov 26; Vol. 7 (48), pp. eabf6123. Date of Electronic Publication: 2021 Nov 24.

Partitioning of cancer therapeutics in nuclear condensates.

Autor: Klein IA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA., Boija A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Afeyan LK; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hawken SW; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Fan M; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Dall'Agnese A; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Oksuz O; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Henninger JE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Shrinivas K; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sabari BR; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Sagi I; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Clark VE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Platt JM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA., Kar M; Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany., McCall PM; Max Planck Institute for the Physics of Complex Systems, 01187 Dresden, Germany.; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.; Center for Systems Biology Dresden, 01307 Dresden, Germany., Zamudio AV; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Manteiga JC; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Coffey EL; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Li CH; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hannett NM; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Guo YE; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Decker TM; Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA., Lee TI; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Zhang T; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Weng JK; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Taatjes DJ; Department of Biochemistry, University of Colorado, Boulder, CO 80303, USA., Chakraborty A; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard Medical School, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sharp PA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chang YT; Department of Chemistry, Pohang University of Science and Technology, and Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 37673, Republic of Korea., Hyman AA; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.; Cluster of Excellence Physics of Life, Technical University of Dresden, 01062 Dresden, Germany., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. young@wi.mit.edu.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Jun 19; Vol. 368 (6497), pp. 1386-1392.

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.

Autor: Guo YE; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Manteiga JC; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Henninger JE; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Sabari BR; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Dall'Agnese A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Hannett NM; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Spille JH; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Physics, University of Illinois at Chicago, Chicago, IL, USA., Afeyan LK; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Zamudio AV; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Shrinivas K; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Institute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Abraham BJ; Whitehead Institute for Biomedical Research, Cambridge, MA, USA.; Computational Biology, St Jude Children's Research Hospital, Memphis, TN, USA., Boija A; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Decker TM; Department of Biochemistry, University of Colorado, Boulder, CO, USA., Rimel JK; Department of Biochemistry, University of Colorado, Boulder, CO, USA., Fant CB; Department of Biochemistry, University of Colorado, Boulder, CO, USA., Lee TI; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Cisse II; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA., Sharp PA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Taatjes DJ; Department of Biochemistry, University of Colorado, Boulder, CO, USA., Young RA; Whitehead Institute for Biomedical Research, Cambridge, MA, USA. young@wi.mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. young@wi.mit.edu.

Publikováno v: Nature [Nature] 2019 Aug; Vol. 572 (7770), pp. 543-548. Date of Electronic Publication: 2019 Aug 07.

High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases.

Autor: Bessen JL; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, 02138, USA., Afeyan LK; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, 02138, USA., Dančík V; Chemical Biology and Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Koblan LW; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, 02138, USA., Thompson DB; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, 02138, USA., Leichner C; Google Inc., Mountain View, CA, 94043, USA., Clemons PA; Chemical Biology and Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, 02142, USA. drliu@fas.harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA. drliu@fas.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, 02138, USA. drliu@fas.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2019 Apr 26; Vol. 10 (1), pp. 1937. Date of Electronic Publication: 2019 Apr 26.