Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

Autor: Kröger, Cornelia, Afeyan, Alexander, Mraz, Jasmin, Eaton, Elinor Ng, Reinhardt, Ferenc, Khodor, Yevgenia L., Thiru, Prathapan, Bierie, Brian, Ye, Xin, Burge, Christopher B., Weinberg, Robert A.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2019 Apr 01. 116(15), 7353-7362.

Externí odkaz: https://www.jstor.org/stable/26701390

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Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans.

Autor: Ludin A; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute; Boston, MA, USA.; These authors contributed equally., Stirtz GL; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.; These authors contributed equally., Tal A; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA., Nirmal AJ; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Ludwig Center at Harvard; Boston, MA, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA.; Department of Systems Biology, Harvard Medical School; Boston, MA, USA., Besson N; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Jones SM; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Pfaff KL; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Manos M; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Liu S; Biophysics Program, Harvard University, Boston, MA 02115, USA.; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Barrera I; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gong Q; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rodrigues CP; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute; Boston, MA, USA., Sahu A; Dermatology Service, Memorial Sloan Kettering Cancer Center; New York, NY, USA.|., Jerison E; Department of Physics, University of Chicago, Chicago, IL 60637, USA, Institute for Biophysical Dynamics, and James Franck Institute., Alessi JV; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Ricciuti B; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Richardson DS; Harvard Center for Biological Imaging, Department of Molecular and Cellular Biology, Harvard University; Cambridge, MA, USA., Weiss JD; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA., Moreau HM; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA., Stanhope ME; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA., Afeyan AB; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA., Sefton J; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA., McCall WD; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA., Formato E; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute; Boston, MA, USA., Yang S; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute; Boston, MA, USA., Zhou Y; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute; Boston, MA, USA., van Konijnenburg DPH; Division of Immunology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Cole HL; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA., Cordova M; Dermatology Service, Memorial Sloan Kettering Cancer Center; New York, NY, USA.|., Deng L; Dermatology Service, Memorial Sloan Kettering Cancer Center; New York, NY, USA.|., Rajadhyaksha M; Dermatology Service, Memorial Sloan Kettering Cancer Center; New York, NY, USA.|., Quake SR; Department of Bioengineering and Applied sciences, Stanford University, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Awad MM; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Chen F; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Sorger PK; Ludwig Center at Harvard; Boston, MA, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA.; Department of Systems Biology, Harvard Medical School; Boston, MA, USA., Hodi FS; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.; Parker Institute for Cancer Immunotherapy., Rodig SJ; Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Murphy GF; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Zon LI; Harvard Stem Cell and Regenerative Biology Department, Harvard University; Boston, MA, USA.; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital and Dana-Farber Cancer Institute; Boston, MA, USA.; Howard Hughes Medical Institute, Harvard medical school; Boston MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 19. Date of Electronic Publication: 2024 Sep 19.