Synthesis of New Congeners of 1-methyl-3-aminoisoquinolines, Evaluation of Their Cytotoxic Activity, In Silico and In Vitro Study of Their Molecular Targets as PDE4B.

Autor: Lapa GB; Blokhin Cancer Center, Kashirskoe sh 24, Moscow, 115478, Russia.; Pirogov Russian National Research Medical University (RNRMU), Ostrovitianov str. 1, Moscow, 117997, Russia., Tsunoda T; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka 814-0180, Japan., Shirasawa S; Department of Cell Biology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.; Central Research Institute for Advanced Molecular Medicine, Fukuoka University, Fukuoka 814-0180, Japan., Baryshnikova MA; Blokhin Cancer Center, Kashirskoe sh 24, Moscow, 115478, Russia., Evseev GG; Blokhin Cancer Center, Kashirskoe sh 24, Moscow, 115478, Russia., Afanasyeva DA; Blokhin Cancer Center, Kashirskoe sh 24, Moscow, 115478, Russia., Chigorina EA; Federal State Unitary Enterprise IREA, Bogorodsky shaft, 3, Moscow, 107076, Russia.

Publikováno v: Chemical biology & drug design [Chem Biol Drug Des] 2016 Apr; Vol. 87 (4), pp. 575-82. Date of Electronic Publication: 2015 Dec 29.