Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Afaf R, Genady"'
Autor:
Rowan Swann, Daniel Hernández-Valdés, Luis Rafael Silva, Yusra Mahmood Marfatia, Mohamed E. El-Zaria, Afaf R. Genady, Jacek M. Kwiecien, John F. Valliant, Saman Sadeghi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The development of a non-invasive infection-specific diagnostic probe holds the potential to vastly improve early-stage detection of infection, enabling precise therapeutic intervention and potentially reducing the incidence of antibiotic re
Externí odkaz:
https://doaj.org/article/c7b341b4b2b24371bd4940472d18e5aa
Autor:
Afaf R. Genady, Samantha R. Slikboer, Rowan Swann, Kevin Wyszatko, Nancy Janzen, Luis Rafael Silva, Mohamed E. El-Zaria, Saman Sadeghi, John F. Valliant
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 4, Iss , Pp 100021- (2022)
Photoacoustic (PA) imaging is a nonradioactive and noninvasive imaging modality that can volumetrically map the distribution of photo-absorbing molecules with deeper tissue penetration than optical modalities. Here, we report on a convenient strategy
Externí odkaz:
https://doaj.org/article/90cffabfae8347119f9b42df3ad7963d
Autor:
Charles A. Maitz, Samantha Delaney, Brendon E. Cook, Afaf R. Genady, Rebecca Hoerres, Marina Kuchuk, Georgios Makris, John F. Valliant, Saman Sadeghi, Jason S. Lewis, Heather M. Hennkens, Jeffrey N. Bryan, Brian M. Zeglis
Publikováno v:
Mol Pharm
The last decade has played witness to the creation of a highly effective approach to in vivo pretargeting based on the inverse electron demand Diels-Alder (IEDDA) click ligation between tetrazine (Tz) and trans-cyclooctene (TCO). Despite the steady p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a6e2a1495044b98593dcf69cc7e61b
https://doi.org/10.1021/acs.molpharmaceut.2c00220
https://doi.org/10.1021/acs.molpharmaceut.2c00220
Autor:
John F. Valliant, Anthony F. Rullo, Saman Sadeghi, Nancy Janzen, Afaf R. Genady, Stephanie M. Rathmann, Shannon Czorny, Varun C. Anipindi
Publikováno v:
Molecular Pharmaceutics. 18:2647-2656
Building on clinical case reports of the abscopal effect, there has been considerable interest in the synergistic effects of radiation and immunotherapies for the treatment of cancer. Here, the first radiolabeled antibody-recruiting small molecule th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b8cc96372347559fe5b5b3948ddfd6
https://doi.org/10.1021/acs.molpharmaceut.1c00187
https://doi.org/10.1021/acs.molpharmaceut.1c00187
Autor:
Alyssa Vito, Hussain Alarabi, Shannon Czorny, Omid Beiraghi, Jeff Kent, Nancy Janzen, Afaf R Genady, Salma A Al-Karmi, Stephanie Rathmann, Zoya Naperstkow, Megan Blacker, Lisset Llano, Paul J Berti, John F Valliant
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171909 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0167425.].
Externí odkaz:
https://doaj.org/article/6fc4cd242af94f67be03c01544ac5bdf
Autor:
Mohamed E. El-Zaria, Mojgan Rezvani, Alex Adronov, Darryl Fong, Afaf R. Genady, Saman Sadeghi, Rowan Swann, John F. Valliant, Stuart A. McNelles, Amber Faraday, Samantha R. Slikboer, Nancy Janzen
Publikováno v:
ACS Applied Nano Materials. 3:11819-11824
Tailoring carbon nanotube surface chemistry is essential for biomedical applications. Bisphosphonate–carbon nanotube conjugates were prepared to target regions of active bone metabolism. The conjug...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ab891a7b692aa8ceebd15e67702bda5
https://doi.org/10.1021/acsanm.0c02339
https://doi.org/10.1021/acsanm.0c02339
Autor:
Alyssa Vito, Hussain Alarabi, Shannon Czorny, Omid Beiraghi, Jeff Kent, Nancy Janzen, Afaf R Genady, Salma A Al-Karmi, Stephanie Rathmann, Zoya Naperstkow, Megan Blacker, Lisset Llano, Paul J Berti, John F Valliant
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167425 (2016)
A convenient strategy to radiolabel a hydrazinonicotonic acid (HYNIC)-derived tetrazine with 99mTc was developed, and its utility for creating probes to image bone metabolism and bacterial infection using both active and pretargeting strategies was d
Externí odkaz:
https://doaj.org/article/869342b574fd4dd2982219fabc8c7142
Autor:
Lynn C. Francesconi, Nancy Janzen, Alyssa Vito, Stephanie M. Rathmann, John F. Valliant, Abdolreza Yazdani, Zainab Ahmad, Holly A. Bilton, Afaf R. Genady, Brian M. Zeglis, Shannon Czorny
Publikováno v:
Journal of Medicinal Chemistry. 59:9381-9389
A high yield synthesis of a novel, small molecule, bisphosphonate-modified trans-cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and captures functionalized tetrazines in vivo, via the bioorthogonal inverse electron demand Die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69296f076cde874642c66d488809a35a
https://doi.org/10.1021/acs.jmedchem.6b00938
https://doi.org/10.1021/acs.jmedchem.6b00938
Autor:
Mahmoud El-Gamal, John F. Valliant, Nancy Janzen, Laura Banevicius, Mohamed E. El-Zaria, Afaf R. Genady
Publikováno v:
Journal of Medicinal Chemistry. 59:2660-2673
The feasibility of developing a single agent that can deliver radioactive iodine and also direct cellular immune function by engaging endogenous antibodies as an antibody-recruiting small molecule (ARM) was determined. A library of new prostate-speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0feef4208ca0b9e7a16e2681c20e480
https://doi.org/10.1021/acs.jmedchem.5b01881
https://doi.org/10.1021/acs.jmedchem.5b01881
Publikováno v:
Nuclear Medicine and Biology. :S12-S13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a31dade133b406fecb1268ae5785582b
https://doi.org/10.1016/s0969-8051(19)30223-9
https://doi.org/10.1016/s0969-8051(19)30223-9