Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Aesha Vakil"'
Autor:
Miranda C. Lahman, Thomas M. Schmitt, Kelly G. Paulson, Nathalie Vigneron, Denise Buenrostro, Felecia D. Wagener, Valentin Voillet, Lauren Martin, Raphael Gottardo, Jason Bielas, Julie M. McElrath, Derek L. Stirewalt, Era L. Pogosova-Agadjanyan, Cecilia C. Yeung, Robert H. Pierce, Daniel N. Egan, Merav Bar, Paul C. Hendrie, Sinéad Kinsella, Aesha Vakil, Jonah Butler, Mary Chaffee, Jonathan Linton, Megan S. McAfee, Daniel S. Hunter, Marie Bleakley, Anthony Rongvaux, Benoit J. Van den Eynde, Aude G. Chapuis, Philip D. Greenberg
Publikováno v:
Sci Transl Med
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Science translational medicine, Vol. 14, no.631, p. eabg8070 (2022)
Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of escape from immunologic targeting in an acute myeloid leukemia (AML) patient, who relapsed 1 y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ab8910054866ad4b7f3c2247308f44
https://doi.org/10.1126/scitranslmed.abg8070
https://doi.org/10.1126/scitranslmed.abg8070
Autor:
Jesse Green, Brian Granger, Ouwen Liang, Jesus Moreno, Andrew Tucker, Aesha Vakil, Reuben Burch, Nicholas Mozdzierz, Matthew Scott-Skandera, Stephanie Riofrio, Mike DeCosta, Amey Gaikwad, Sanket Phadke, Kaely Gallagher, Adam Charlton, Sarah Miller, Hosein Kouros-Mehr, Misha Shamashkin, Neal Van Hoeven, Kutlu Elpek, Terry Fry
Publikováno v:
Cancer Research. 83:LB311-LB311
Introduction: Fusosomes are viral vectors pseudotyped with modified paramyxovirus envelopes targeting specific cell types. A CD8-targeted fusosome delivering CD19CAR transgene has the potential to provide an off-the-shelf therapeutic approach to gene
Autor:
Qian Wu, Mazyar Shadman, Stanley R. Riddell, Utkarsh Acharya, Hans-Peter Kiem, Jordan Gauthier, Sindhu Cherian, Aesha Vakil, Ted Gooley, Jorge Ramos, Alexandre V. Hirayama, Barbara S. Pender, David G. Maloney, Ryan D. Cassaday, Xueyan Chen, Reed M. Hawkins, Gary Schoch, Rachel N. Steinmetz, Daniel Li, Jenna M. Voutsinas, Brian G. Till, Cameron J. Turtle, Aude G. Chapuis, Kevin A. Hay
Publikováno v:
Blood. 133:1652-1663
Autologous T cells engineered to express a CD19-specific chimeric antigen receptor (CAR) have produced impressive minimal residual disease–negative (MRD-negative) complete remission (CR) rates in patients with relapsed/refractory B-cell acute lymph
Autor:
Kristin G. Anderson, Yapeng Su, Madison G. Burnett, Breanna M. Bates, Magdalia L. Rodgers Suarez, Susan L. Ruskin, Aesha Vakil, Valentin Voillet, Raphael Gottardo, Philip Greenberg
Publikováno v:
Cancer Research. 82:3608-3608
Background: Less than half of ovarian cancer patients survive five years after diagnosis. This rate has changed little in the last 30 years, highlighting the need for novel therapies. A promising new strategy with the potential to control tumor growt
Autor:
Aesha Vakil, Rachel N. Steinmetz, Salvatore Fiorenza, Evandro D. Bezerra, Ryan D. Cassaday, Alyssa Sheih, Mazyar Shadman, Tinh-Doan Phi, David G. Maloney, Alexandre V. Hirayama, Filippo Milano, Barbara S. Pender, Aude G. Chapuis, Abby W. Jamieson, Damian J. Green, Merav Bar, Jordan Gauthier, Brian G. Till, Cameron J. Turtle, Stanley R. Riddell, Reed M. Hawkins, Hans-Peter Kiem, Andrew J. Cowan, Erik Kimble, Cassie K. Chou
Publikováno v:
Blood
CD19-targeted chimeric antigen receptor-engineered (CD19 CAR) T-cell therapy has shown significant efficacy for relapsed or refractory (R/R) B-cell malignancies. Yet, CD19 CAR T cells fail to induce durable responses in most patients. Second infusion
Autor:
Alexandre V. Hirayama, Tinh-Doan Phi, Rachel N. Steinmetz, Jordan Gauthier, David G. Maloney, Cameron J. Turtle, Daniel Li, Barbara S. Pender, Aesha Vakil, James Lymp, Kevin A. Hay, Alyssa Sheih, Janaki Purushe, Reed M. Hawkins, S.R. Riddell
Publikováno v:
Hematological Oncology. 37:168-170
Autor:
Magdalia Rodgers Suarez, Raphael Gottardo, Valentin Voillet, Philip D. Greenberg, Kristin E. Anderson, Yapeng Su, Aesha Vakil, Madison G. Burnett, Susan L. Ruskin, Breanna M. Bates
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A590-A590
BackgroundOver 20,000 women are diagnosed with ovarian cancer annually, and more than half will die within 5 years. This rate has changed little in the last 20 years, highlighting the need for therapy innovation. A promising new strategy with the pot
Autor:
Salvatore Fiorenza, Cameron J. Turtle, Jonathan L. Golob, Steven A. Pergam, Aesha Vakil, Samuel S. Minot, Delaney R. Kirchmeier, Alyssa Sheih, Filippo Milano, Tinh-Doan Phi, Colleen Delaney, Sujatha Srinivasan, Alexandre V. Hirayama, Erin E Peterson, David N. Fredricks
Publikováno v:
Transplantation and Cellular Therapy. 27:S90-S91
Autor:
Angela J. Waanders, Daphne A. Haas-Kogan, Payal Jain, Phillip B. Storm, Aleksandra Olow, Shih-Shan Lang, Tiffany Smith, Christine Busch, Sabine Mueller, Elizabeth Fox, Aesha Vakil, Xiaodong Yang, Amanda Silva, Adam C. Resnick, Namrata Choudhari, Pichai Raman, Harry J. Han, Yuankun Zhu, Tim Delaney, Patrick Diviney, Katie Boucher
Publikováno v:
Oncotarget
// Payal Jain 1,2,3 , Amanda Silva 1 , Harry J. Han 2 , Shih-Shan Lang 1,2 , Yuankun Zhu 1,3 , Katie Boucher 1,2,3 , Tiffany E. Smith 1,2,3 , Aesha Vakil 4 , Patrick Diviney 5 , Namrata Choudhari 1,2,3 , Pichai Raman 3,6,7 , Christine M. Busch 8 , Ti
Autor:
Tamara Fierst, Tiffany Smith, Aesha Vakil, Angela J. Waanders, Adam C. Resnick, Phillip B. Storm, Harry J. Han, Payal Jain
Publikováno v:
Oncogene
Pediatric low-grade gliomas (PLGGs) are commonly associated with BRAF gene fusions that aberrantly activate the mitogen-activated protein kinase (MAPK) signaling pathway. This has led to PLGG clinical trials utilizing RAF- and MAPK pathway-targeted t