Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Aeron C Hurt"'
Autor:
Wuji Zhang, Louise C Rowntree, Ramona Muttucumaru, Timon Damelang, Malet Aban, Aeron C Hurt, Maria Auladell, Robyn Esterbauer, Bruce Wines, Mark Hogarth, Stephen J Turner, Adam K Wheatley, Stephen J Kent, Sushrut Patil, Sharon Avery, Orla Morrissey, Amy W Chung, Marios Koutsakos, Thi HO Nguyen, Allen C Cheng, Tom C Kotsimbos, Katherine Kedzierska
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Objectives Influenza causes significant morbidity and mortality, especially in high‐risk populations. Although current vaccination regimens are the best method to combat annual influenza disease, vaccine efficacy can be low in high‐risk
Externí odkaz:
https://doaj.org/article/19f39f7a518347a7bba2b6246a782664
Autor:
Michelle Wille, Victoria Grillo, Silvia Ban de Gouvea Pedroso, Graham W Burgess, Allison Crawley, Celia Dickason, Philip M Hansbro, Md Ahasanul Hoque, Paul F Horwood, Peter D Kirkland, Nina Yu-Hsin Kung, Stacey E Lynch, Sue Martin, Michaela McArthur, Kim O'Riley, Andrew J Read, Simone Warner, Bethany J Hoye, Simeon Lisovski, Trent Leen, Aeron C Hurt, Jeff Butler, Ivano Broz, Kelly R Davies, Patrick Mileto, Matthew J Neave, Vicky Stevens, Andrew C Breed, Tommy T Y Lam, Edward C Holmes, Marcel Klaassen, Frank Y K Wong
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010150 (2022)
Most of our understanding of the ecology and evolution of avian influenza A virus (AIV) in wild birds is derived from studies conducted in the northern hemisphere on waterfowl, with a substantial bias towards dabbling ducks. However, relevant environ
Externí odkaz:
https://doaj.org/article/7812edd542354284bc57fd392409f9c5
Autor:
Leo Y Lee, Jie Zhou, Paulina Koszalka, Rebecca Frise, Rubaiyea Farrukee, Keiko Baba, Shahjahan Miah, Takao Shishido, Monica Galiano, Takashi Hashimoto, Shinya Omoto, Takeki Uehara, Edin J Mifsud, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Steffen Wildum, Wendy S Barclay, Aeron C Hurt
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009527 (2021)
Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses with reduced susceptibility to baloxavir have been detected in clinical trials, but the li
Externí odkaz:
https://doaj.org/article/6a080755b2e74791b2fa666dd6d94232
Autor:
Rubaiyea Farrukee, Celeste Ming-Kay Tai, Ding Yuan Oh, Danielle E Anderson, Vithiagaran Gunalan, Martin Hibberd, Gary Yuk-Fai Lau, Ian G Barr, Veronika von Messling, Sebastian Maurer-Stroh, Aeron C Hurt
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008592 (2020)
The neuraminidase (NA) inhibitor (NAI) oseltamivir (OST) is the most widely used influenza antiviral drug. Several NA amino acid substitutions are reported to reduce viral susceptibility to OST in in vitro assays. However, whether there is a correlat
Externí odkaz:
https://doaj.org/article/8077b174301144968624520fb39ef22e
Autor:
Leo Yi Yang Lee, Jie Zhou, Rebecca Frise, Daniel H Goldhill, Paulina Koszalka, Edin J Mifsud, Kaoru Baba, Takahiro Noda, Yoshinori Ando, Kenji Sato, Aoe-Ishikawa Yuki, Takao Shishido, Takeki Uehara, Steffen Wildum, Elke Zwanziger, Neil Collinson, Klaus Kuhlbusch, Barry Clinch, Aeron C Hurt, Wendy S Barclay
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008395 (2020)
Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza control, their efficacy varies each season and a vaccine for a novel pandemic virus manufactured using current technology
Externí odkaz:
https://doaj.org/article/61b97708882143f882083c1fe0a052d6
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233794 (2020)
The domestic ferret (Mustela putorius furo) provides a critical animal model to study human respiratory diseases. However immunological insights are restricted due to a lack of ferret-specific reagents and limited genetic information about ferret B a
Externí odkaz:
https://doaj.org/article/5e2bd5c1d5224888b151fa90b56a698e
Autor:
Juhye M Lee, Rachel Eguia, Seth J Zost, Saket Choudhary, Patrick C Wilson, Trevor Bedford, Terry Stevens-Ayers, Michael Boeckh, Aeron C Hurt, Seema S Lakdawala, Scott E Hensley, Jesse D Bloom
Publikováno v:
eLife, Vol 8 (2019)
A longstanding question is how influenza virus evolves to escape human immunity, which is polyclonal and can target many distinct epitopes. Here, we map how all amino-acid mutations to influenza’s major surface protein affect viral neutralization b
Externí odkaz:
https://doaj.org/article/2119b3de6f684d84a4356f027f1983d8
Autor:
Annika Suttie, Songha Tok, Sokhoun Yann, Ponnarath Keo, Srey Viseth Horm, Merryn Roe, Matthew Kaye, San Sorn, Davun Holl, Sothyra Tum, Ian G Barr, Aeron C Hurt, Andrew R Greenhill, Erik A Karlsson, Dhanasekaran Vijaykrishna, Yi-Mo Deng, Philippe Dussart, Paul F Horwood
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0225428 (2019)
Low pathogenic A(H9N2) subtype avian influenza viruses (AIVs) were originally detected in Cambodian poultry in 2013, and now circulate endemically. We sequenced and characterised 64 A(H9N2) AIVs detected in Cambodian poultry (chickens and ducks) from
Externí odkaz:
https://doaj.org/article/f39d8aabb877468c9fe6efff81673e1f
Autor:
Nicola L Bird, Matthew R Olson, Aeron C Hurt, Christine M Oshansky, Ding Yuan Oh, Patrick C Reading, Brendon Y Chua, Yilun Sun, Li Tang, Andreas Handel, David C Jackson, Stephen J Turner, Paul G Thomas, Katherine Kedzierska
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129768 (2015)
CD8(+) T cells directed against conserved viral regions elicit broad immunity against distinct influenza viruses, promote rapid virus elimination and enhanced host recovery. The influenza neuraminidase inhibitor, oseltamivir, is prescribed for therap
Externí odkaz:
https://doaj.org/article/7e29b53b203047a28b74b60edca55995
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118780 (2015)
Ferrets are the preferred animal model to assess influenza virus infection, virulence and transmission as they display similar clinical symptoms and pathogenesis to those of humans. Measures of disease severity in the ferret include weight loss, temp
Externí odkaz:
https://doaj.org/article/a964f5f5c27e46fba6443e7b546799b4