Zobrazeno 1 - 10
of 349
pro vyhledávání: '"Aeron C Hurt"'
Autor:
Harry L. Stannard, Edin J. Mifsud, Steffen Wildum, Sook Kwan Brown, Paulina Koszalka, Takao Shishido, Satoshi Kojima, Shinya Omoto, Keiko Baba, Klaus Kuhlbusch, Aeron C. Hurt, Ian G. Barr
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
A clinical influenza isolate with dual antiviral resistant mutations displays a moderate loss of viral fitness in ferrets compared to wild-type virus, suggesting widespread community transmission of this dual mutant is unlikely.
Externí odkaz:
https://doaj.org/article/450f13fea2434b3a881cfa9fa16c3fa5
Autor:
Gary P. Anderson, Louis B. Irving, Andrew Jarnicki, Katherine Kedzierska, Marios Koutsakos, Stephen Kent, Aeron C. Hurt, Adam K. Wheatley, Thi H.O. Nguyen, Natale Snape, John W. Upham
Publikováno v:
ERJ Open Research, Vol 9, Iss 2 (2023)
Background COPD patients are more susceptible to viral respiratory infections and their sequelae, and have intrinsically weaker immune responses to vaccinations against influenza and other pathogens. Prime-boost, double-dose immunisation has been sug
Externí odkaz:
https://doaj.org/article/a5d119f8618a45ac92bd5a1942ed7bc7
Autor:
Natale Snape, Gary P. Anderson, Louis B. Irving, Andrew G. Jarnicki, Aeron C. Hurt, Tina Collins, Yang Xi, John W. Upham
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Though clinical guidelines recommend influenza vaccination for chronic obstructive pulmonary disease (COPD) patients and other high-risk populations, it is unclear whether current vaccination strategies induce optimal antibody responses. Thi
Externí odkaz:
https://doaj.org/article/459c635dd50f4d52aa55ff5c815182cf
Autor:
Wuji Zhang, Louise C Rowntree, Ramona Muttucumaru, Timon Damelang, Malet Aban, Aeron C Hurt, Maria Auladell, Robyn Esterbauer, Bruce Wines, Mark Hogarth, Stephen J Turner, Adam K Wheatley, Stephen J Kent, Sushrut Patil, Sharon Avery, Orla Morrissey, Amy W Chung, Marios Koutsakos, Thi HO Nguyen, Allen C Cheng, Tom C Kotsimbos, Katherine Kedzierska
Publikováno v:
Clinical & Translational Immunology, Vol 12, Iss 6, Pp n/a-n/a (2023)
Abstract Objectives Influenza causes significant morbidity and mortality, especially in high‐risk populations. Although current vaccination regimens are the best method to combat annual influenza disease, vaccine efficacy can be low in high‐risk
Externí odkaz:
https://doaj.org/article/19f39f7a518347a7bba2b6246a782664
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Amino acid substitutions I38T and E23K in the influenza polymerase acidic (PA) protein lead to reduced susceptibility to the influenza antiviral drug baloxavir. The in vivo effectiveness of baloxavir and oseltamivir for treatment of these vi
Externí odkaz:
https://doaj.org/article/3017cf9ddedd4f319d4d87fbbd64147f
Autor:
Thi H. O. Nguyen, Marios Koutsakos, Carolien E. van de Sandt, Jeremy Chase Crawford, Liyen Loh, Sneha Sant, Ludivine Grzelak, Emma K. Allen, Tim Brahm, E. Bridie Clemens, Maria Auladell, Luca Hensen, Zhongfang Wang, Simone Nüssing, Xiaoxiao Jia, Patrick Günther, Adam K. Wheatley, Stephen J. Kent, Malet Aban, Yi-Mo Deng, Karen L. Laurie, Aeron C. Hurt, Stephanie Gras, Jamie Rossjohn, Jane Crowe, Jianqing Xu, David Jackson, Lorena E. Brown, Nicole La Gruta, Weisan Chen, Peter C. Doherty, Stephen J. Turner, Tom C. Kotsimbos, Paul G. Thomas, Allen C. Cheng, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The immunological parameters that define severe influenza disease are not clear within human real time infections. Here the authors compare a severe influenza infection cohort with an influenza vaccinated cohort to understand correlates of severe inf
Externí odkaz:
https://doaj.org/article/2bb8c377813f4ec9954ac0d874794b8f
Autor:
Michelle Wille, Victoria Grillo, Silvia Ban de Gouvea Pedroso, Graham W. Burgess, Allison Crawley, Celia Dickason, Philip M. Hansbro, Md. Ahasanul Hoque, Paul F. Horwood, Peter D. Kirkland, Nina Yu-Hsin Kung, Stacey E. Lynch, Sue Martin, Michaela McArthur, Kim O’Riley, Andrew J. Read, Simone Warner, Bethany J. Hoye, Simeon Lisovski, Trent Leen, Aeron C. Hurt, Jeff Butler, Ivano Broz, Kelly R. Davies, Patrick Mileto, Matthew J. Neave, Vicky Stevens, Andrew C. Breed, Tommy T. Y. Lam, Edward C. Holmes, Marcel Klaassen, Frank Y. K. Wong
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5 (2022)
Most of our understanding of the ecology and evolution of avian influenza A virus (AIV) in wild birds is derived from studies conducted in the northern hemisphere on waterfowl, with a substantial bias towards dabbling ducks. However, relevant environ
Externí odkaz:
https://doaj.org/article/597dd63c93ea48d69a56872424a6de66
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Seasonal influenza epidemics vary in timing and size, but the causes of the variation remain unclear. Here, the authors analyse a 15-year city-level data set, and find that fluctuations in climatic factors do not predict onset timing, and that while
Externí odkaz:
https://doaj.org/article/0a97106ffd63441a8a94a950055a9361
Autor:
Su-Jhen Hung, Yin-Mei Hsu, Sheng-Wen Huang, Huey-Pin Tsai, Leo Yi Yang Lee, Aeron C. Hurt, Ian G. Barr, Shin-Ru Shih, Jen-Ren Wang
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-13 (2020)
Abstract Background Influenza A viruses cause epidemics/severe pandemics that pose a great global health threat. Among eight viral RNA segments, the multiple functions of nucleoprotein (NP) play important roles in viral replication and transcription.
Externí odkaz:
https://doaj.org/article/e0c30568f8ab4883a73c44311347a8b5
Autor:
Michelle Wille, Simeon Lisovski, Alice Risely, Marta Ferenczi, David Roshier, Frank Y.K. Wong, Andrew C. Breed, Marcel Klaassen, Aeron C. Hurt
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 10, Pp 1903-1910 (2019)
Highly pathogenic avian influenza (HPAI) H5Nx viruses of the goose/Guangdong/96 lineage continue to cause outbreaks in poultry and wild birds globally. Shorebirds, known reservoirs of avian influenza viruses, migrate from Siberia to Australia along t
Externí odkaz:
https://doaj.org/article/e3b72ad3fa3c4574b1b64cb2ac82892d