Review of Drug Development Guidance to Treat Chronic Obstructive Pulmonary Disease: US and EU Perspectives

Autor: Lorcan McGarvey, Aernout D. van Haarst, Sabina Paglialunga

Publikováno v: van Haarst, A, McGarvey, L & Paglialunga, S 2019, ' Review of Drug Development Guidance to Treat Chronic Obstructive Pulmonary Disease: US and EU Perspectives ', Clinical Pharmacology and Therapeutics, vol. 106, no. 6, pp. 1222-1235 . https://doi.org/10.1002/cpt.1540
Clinical Pharmacology and Therapeutics

Chronic obstructive pulmonary disease (COPD) remains a leading cause of death worldwide, yet only one new drug class has been approved in the last decade. However, resurgence in COPD treatment has been recently fueled by a greater understanding of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3515cd580aef09d79b9a358e5bfba8
https://doi.org/10.1002/cpt.1540

Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function

Autor: Ad A.M. Masclee, Ingrid M C Kamerling, Adam F. Cohen, Aernout D. van Haarst, Marieke L. de Kam, Hartmut Heinzerling, Jacobus Burggraaf, Rik C. Schoemaker

Publikováno v: British Journal of Clinical Pharmacology. 57:393-401

Aim To assess the effects of the motilin receptor antagonist RWJ-68023 on basal and motilin-stimulated proximal gastric volume. Methods Eighteen healthy male volunteers received RWJ-68023 in two different doses or placebo for 135 min. After 45 min, s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d098c8e86e78ff60a42aa9ff35e52e1
https://doi.org/10.1046/j.1365-2125.2003.02034.x

11β-Hydroxysteroid Dehydrogenase Activity in the Hippocampus: Implications forin vivoCorticosterone Receptor Binding and Cell Nuclear Retention

Autor: Aernout D. van Haarst, Melly S. Oitzl, E. Ron de Kloet, Leonie Welberg, W. Sutanto

Publikováno v: Journal of Neuroendocrinology. 8:595-600

In this study a possible role of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) in altering the access of corticosteroids to their receptors in the hippocampus is investigated. In vitro, oxidation of corticosterone to 11-dehydrocorticosterone (11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96bd796a734ff43c5f0942df67287e92
https://doi.org/10.1111/j.1365-2826.1996.tb00693.x

Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function

Autor: Ingrid M C, Kamerling, Aernout D, van Haarst, Jacobus, Burggraaf, Rik C, Schoemaker, Marieke L, de Kam, Hartmut, Heinzerling, Adam F, Cohen, Ad A M, Masclee

Publikováno v: British journal of clinical pharmacology. 57(4)

To assess the effects of the motilin receptor antagonist RWJ-68023 on basal and motilin-stimulated proximal gastric volume.Eighteen healthy male volunteers received RWJ-68023 in two different doses or placebo for 135 min. After 45 min, subjects recei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd1e8eb4a82c5e1987be076ce3f7aec9
https://pubmed.ncbi.nlm.nih.gov/15025736

Corticosterone, brain mineralocorticoid receptors (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: the Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis

Autor: Melly S. Oitzl, E. Ron de Kloet, Aernout D. van Haarst, W. Sutanto

Publikováno v: Psychoneuroendocrinology. 20(6)

In this study we report a series of differences in brain and peripheral elements regulating the hypothalamic-pituitary-adrenal (HPA) axis between male LEW and Wistar rats. We found: (i) differential properties of mineralocorticoid receptors (MRs) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa86a4a125fdd66a7e7a69bd29629ab
https://pubmed.ncbi.nlm.nih.gov/8584606