Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Aengus, Mac Sweeney"'
Autor:
Aengus Mac Sweeney, Alain Chambovey, Micha Wicki, Manon Müller, Nadia Artico, Roland Lange, Aleksandar Bijelic, Joscha Breibeck, Annette Rompel
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199639 (2018)
The use of the tellurium-centered Anderson-Evans polyoxotungstate [TeW6O24]6- (TEW) as a crystallization additive has been described. Here, we present the use of TEW as an additive in the crystallization screening of the nucleotide binding domain (NB
Externí odkaz:
https://doaj.org/article/f998f584c5c44a2b990db3842d71b04e
Autor:
Véronique Pons, Cédric Garcia, Naomi Tidten-Luksch, Aengus Mac Sweeney, Eva Caroff, Céline Galés, Markus A. Riederer
Publikováno v:
Biochemical pharmacology. 206
Selatogrel is a potent inhibitor of adenosine diphosphate (ADP) binding to the P2Y12 receptor, preventing platelet activation. We have previously shown that the P2Y12 receptor constitutively activates Gi- and Go-protein-mediated signaling in human pl
Autor:
Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams
Publikováno v:
Journal of Medicinal Chemistry. 63:5697-5722
Autor:
Stefanie Flohr, Simon Rüdisser, Anna Vulpetti, Andrea De Erkenez, Stefan Steinbacher, Olivier Rogel, Laurence Kieffer, Solene Dussauge, Louis Yang, Frederic Cumin, Karen Anderson, Aengus Mac Sweeney, Edwige Lorthiois, Nils Ostermann, Ronald Newton, Viral Kansara, Sha-Mei Liao, Ulrich Hommel, Constanze Hartwieg, Upendra A. Argikar, Stefan Andreas Randl, Laura R. La Bonte, Omar Delgado, Kamal Fettis, Jürgen Maibaum, Bruce D Jaffee
Publikováno v:
Journal of Medicinal Chemistry. 60:5717-5735
The highly specific S1 serine protease factor D (FD) plays a central role in the amplification of the complement alternative pathway (AP) of the innate immune system. Genetic associations in humans have implicated AP activation in age-related macular
Autor:
Paul Erbel, Bernd Gerhartz, Frederic Cumin, Jürgen Maibaum, Nils Ostermann, Edwige Lorthiois, Claudio Dalvit, Thomas Zoller, Stefan Andreas Randl, Simon Rüdisser, Ulrich Hommel, Anna Vulpetti, Aengus Mac Sweeney, Bahaa Salem
Publikováno v:
Journal of Medicinal Chemistry. 60:1946-1958
Chronic dysregulation of alternative complement pathway activation has been associated with diverse clinical disorders including age-related macular degeneration and paroxysmal nocturnal hemoglobinurea. Factor D is a trypsin-like serine protease with
Autor:
Anna Vulpetti, Upendra A. Argikar, Stefanie Flohr, Aengus Mac Sweeney, Melissa Prentiss, Edwige Lorthiois, Karen Anderson, David B. Belanger, Sha-Mei Liao, Nan Ji, Christopher M. Adams, Frederic Cumin, Andrea De Erkenez, Nathalie Gradoux, Muneto Mogi, Donglei Liu, Maura Crowley, Keith Jendza, Debby Long, Nello Mainolfi, Catherine Solovay, Ann Brown, Laura R. La Bonte, Rajeshri Ganesh Karki, Omar Delgado, Powers James J, Bruce D Jaffee, Christine F. Gelin
Publikováno v:
Journal of medicinal chemistry. 62(9)
Complement factor D (FD), a highly specific S1 serine protease, plays a central role in the amplification of the alternative complement pathway (AP) of the innate immune system. Dysregulation of AP activity predisposes individuals to diverse disorder
Autor:
Samu Melkko, N. Jarousse, David Archer Ellis, Finton Sirockin, A. Bernardi, Aengus Mac Sweeney, Paul Erbel, Paul Ramage, Philipp Grosche, Eva Altmann, Keith D. Combrink, Nicola Hughes
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:438-443
Adenoviral infections are associated with a wide range of acute diseases, among which ocular viral conjunctivitis (EKC) and disseminated disease in immunocompromised patients. To date, no approved specific anti-adenoviral drug is available, but there
Autor:
Eva Altmann, A. Bernardi, Paul Erbel, Aengus Mac Sweeney, N. Jarousse, Paul Ramage, Philipp Grosche, Keith D. Combrink, Nicola Hughes, David Archer Ellis, Samu Melkko, Finton Sirockin
Publikováno v:
ACS Medicinal Chemistry Letters. 5:937-941
The cysteine protease adenain is the essential protease of adenovirus and, as such, represents a promising target for the treatment of ocular and other adenoviral infections. Through a concise two-pronged hit discovery approach we identified tetrapep
Autor:
Frederic Cumin, Bernd Kinzel, Anna Vulpetti, Antonio M. Risitano, Richard A. Harrison, Kamal Fettis, Aengus Mac Sweeney, Stefan Andreas Randl, Edwige Lorthiois, Fabrice A. Kolb, Nils Ostermann, Solene Dussauge, Corinne Durand, Nicola Hughes, Bernd Gerhartz, Karen Anderson, Samuel Barbieri, Paul Erbel, Omar Delgado, Jörg Eder, Ulrich Hommel, Stefanie Flohr, Simon Rüdisser, Anna Schubart, Ty Gould, Bruce D Jaffee, Jürgen Maibaum, Julia Wagner, Sha-Mei Liao
Publikováno v:
Nature chemical biology. 12(12)
Complement is a key component of the innate immune system, recognizing pathogens and promoting their elimination. Complement component 3 (C3) is the central component of the system. Activation of C3 can be initiated by three distinct routes-the class
Autor:
Christian Oefner, Roland Lange, Philip Proteau, Alice Douangamath, Aengus Mac Sweeney, Roberta P.M. Fernandes, Henk Schulz, Glenn E. Dale
Publikováno v:
Journal of Molecular Biology. 345:115-127
The key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) has been shown to be the target enzyme of fosmidomycin, an antimalarial, antibacterial and herbicidal compound. Here we rep