Role of infiltrating monocytes/macrophages in acute and chronic neuroinflammation: Effects on cognition, learning and affective behaviour

Autor: Aedín M. Minogue

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 79:15-18

Peripheral macrophages have limited capacity to gain access to the brain parenchyma under normal physiological conditions. However, accumulating evidence indicates that significant trafficking to the central nervous systems occurs in response to inju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0745950722b2c510364187143b51555d
https://doi.org/10.1016/j.pnpbp.2017.02.008

Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes

Autor: Amy M. Buckley, Lucy A. Crompton, Aedín M. Minogue, Catherine E. Gilmore, Simon J. Hawkins, Natalia Jiménez-Moreno, Jon D. Lane, Stephen Kelly, Margaret Saunders, Maeve A. Caldwell, Petros Stathakos, Oscar Cordero-Llana, C. Patrick Case, Noreen T. Boyle, Aman Sood, Sarah F. McComish

Publikováno v: Hawkins, S J, Crompton, L A, Sood, A, Saunders, M, Boyle, N T, Buckley, A, Minogue, A M, McComish, S F, Jiménez-Moreno, N, Cordero-Llana, O, Stathakos, P, Gilmore, C E, Kelly, S, Lane, J D, Case, C P & Caldwell, M A 2018, ' Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes ', Nature Nanotechnology, vol. 13, pp. 427-433 . https://doi.org/10.1038/s41565-018-0085-3

The potential for maternal nanoparticle (NP) exposures to cause developmental toxicity in the fetus without the direct passage of NPs has previously been shown, but the mechanism remained elusive. We now demonstrate that exposure of cobalt and chromi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3668f16d4ca6e2c31b317893c96afb
https://hdl.handle.net/1983/93848e3a-cd8d-4998-8975-d2f164667224

Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages

Autor: Aidan Falvey, James P. Barrett, Marina A. Lynch, Aedín M. Minogue

Publikováno v: Experimental Cell Research. 335:258-268

Macrophages can be polarised to adopt the M1 or M2 phenotype and functional outcomes of activation include altered secretion of immune molecules such as insulin-like growth factor (IGF)-1 as well as upregulation of cell surface molecules specifically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba3327c35019cdc5c5da56c9ea0b2c9
https://doi.org/10.1016/j.yexcr.2015.05.015

β-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins

Autor: Dennis J. Selkoe, Martin Citron, Matthias Staufenbiel, Julia V. Fadeeva, Aedín M. Minogue, Fred Van Leuven, Dominic M. Walsh, Paolo Paganetti, Carlo Sala Frigerio

Publikováno v: FEBS Journal. 277:1503-1518

The amyloid precursor family of proteins are of considerable interest, both because of their role in Alzheimer's disease pathogenesis and because of their normal physiological functions. In mammals, the amyloid precursor protein (APP) has two homolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38a426bc9cf381273e66a691e0749937
https://doi.org/10.1111/j.1742-4658.2010.07579.x

Inhibition of Amyloid β Protein Fibrillation by Polymeric Nanoparticles

Autor: Aedín M. Minogue, Eva Thulin, Kenneth A. Dawson, Fiona Quinlan-Pluck, Celia Cabaleiro-Lago, Dominic M. Walsh, Sara Linse, Stina Lindman, Iseult Lynch

Publikováno v: Journal of the American Chemical Society. 130:15437-15443

Copolymeric NiPAM:BAM nanoparticles of varying hydrophobicity were found to retard fibrillation of the Alzheimer's disease-associated amyloid beta protein (Abeta). We found that these nanoparticles affect mainly the nucleation step of Abeta fibrillat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92be57678eb03c35a710c3367c2c0ddf
https://doi.org/10.1021/ja8041806