Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ae Yil Kim"'
Autor:
Philippe Van Rompaey, Liaman K. Mamedova, Lak Shin Jeong, Kenneth A. Jacobson, Zhan-Guo Gao, Tatiana Sonina, Bruce T. Liang, Hea Ok Kim, Serge Van Calenbergh, Myong Jung Kim, Ae Yil Kim, Heng T. Duong, Soo-Kyung Kim
Publikováno v:
Journal of Medicinal Chemistry. 49:2689-2702
An alternative approach to overcome the inherent lack of specificity of conventional agonist therapy can be the reengineering of the GPCRs and their agonists. A reengineered receptor (neoceptor) could be selectively activated by a modified agonist, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1869e4ec511d5a70be139a77a0d0d6a4
https://doi.org/10.1021/jm050968b
https://doi.org/10.1021/jm050968b
Autor:
Ae Yil Kim, Seung Ah Choe, Kenneth A. Jacobson, Hyung Ryong Moon, Zhan-Guo Gao, Moon Woo Chun, Lak Shin Jeong, Hea Ok Kim
Publikováno v:
Nucleosides Nucleotides Nucleic Acids
Several N(6)-substituted 3′-ureidoadenosine derivatives were efficiently synthesized starting from d-glucose for the development of H272E mutant A(3) adenosine receptor (AR) agonists. Among compounds tested, 3′-ureido-N (6)-(3-iodobenzyl)adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b40c8701d7d4df173dcf310062fb48
https://doi.org/10.1080/15257770701493161
https://doi.org/10.1080/15257770701493161
Autor:
Hea Ok Kim, Moon Woo Chun, Hyouk Woo Lee, Zhan-Guo Gao, Myong Jung Kim, Kenneth A. Jacobson, Lak Shin Jeong, Ae Yil Kim
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 24:1119-1121
Novel 3'-ureidoadenosine analogues were synthesized from 1,2:5, 6-di-O-isopropylidene-D-glucose in order to lead to stronger hydrogen bonding at the A3 adenosine receptor than the corresponding 3'-aminoadenosine derivatives. However, all synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db22de8f6f2baa348029ae1c68f51fa
https://doi.org/10.1081/ncn-200060079
https://doi.org/10.1081/ncn-200060079
Autor:
Hea Ok Kim, Ae Yil Kim, Myoung Jung Kim, Lak Shin Jeong, Kenneth A. Jacobson, Kang Man Lee, Moon Woo Chun
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb627b2caa02cd8e56d20d1884fa1104
https://doi.org/10.1002/chin.200829254
https://doi.org/10.1002/chin.200829254
Autor:
Kenneth A. Jacobson, Zhan-Guo Gao, Ae Yil Kim, Hyung Ryong Moon, Moon Woo Chun, Hea Ok Kim, Seung Ah Choe, Lak Shin Jeong
Publikováno v:
ChemInform. 39
Several N 6 -substituted 3 ′-ureidoadenosine derivatives were efficiently synthesized starting from D-glucose for the development of H272E mutant A 3 adenosine receptor (AR) agonists. Among compounds tested, 3 ′-ureido-N 6 -(3-iodobenzyl)adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7732d8e10377e0dc794348bdf3bec719
https://doi.org/10.1002/chin.200811239
https://doi.org/10.1002/chin.200811239
Autor:
Andrei A. Ivanov, Lak Shin Jeong, Rebecca Greaves, Ae Yil Kim, Pedro Besada, Kenneth A. Jacobson, Hayamitsu Adachi, Seung Ah Choe, Krishnan K. Palaniappan, Hea Ok Kim, Zhan-Guo Gao
His272 (7.43) in the seventh transmembrane domain (TM7) of the human A3 adenosine receptor (AR) interacts with the 3′ position of nucleosides, based on selective affinity enhancement at a H272E mutant A3 AR (neoceptor) of 3′-ureido, but not 3′-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af09db1a245591da13356a170dcc028b
https://europepmc.org/articles/PMC3140710/
https://europepmc.org/articles/PMC3140710/
Synthesis of 3′-ureidoadenosines and their high binding affinity at the mutant A3 adenosine receptor
Autor:
Hea Ok Kim, Myoung Jung Kim, L. S. Jeong, Kang Man Lee, Moon Woo Chun, Ae Yil Kim, Kenneth A. Jacobson
Publikováno v:
Nucleic Acids Symposium Series. 49:105-106
For the purpose of developing optimal neoceptor-neoagonist pair, 3'-ureidoadenosine derivatives were synthesized. Among compounds tested, 2-chloro-3'-ureido-N6-(3-iodobenzyl)adenosine (10b) showed the best binding affinity (Ki = 0.20 microM) at the H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de69c52c100bb9e43003d99ef66c65dc
https://doi.org/10.1093/nass/49.1.105
https://doi.org/10.1093/nass/49.1.105
Autor:
Palaniappan, Krishnan K., Zhan-Guo Gao, Ivanov, Andrei A., Greaves, Rebecca, Adachi, Hayamitsu, Besada, Pedro, Hea Ok Kim, Ae Yil Kim, Seung Ah Choe, Lak Shin Jeong, Jacobson, Kenneth A.
Publikováno v:
Biochemistry; 6/26/2007, Vol. 46 Issue 25, p7437-7448, 12p, 3 Charts, 3 Graphs
Autor:
Moon Woo Chun, Hyouk Woo Lee, Ae Yil Kim, Myong Jung Kim, Hea Ok Kim, Zhan-Guo Gao, Jacobson, Kenneth, Lak Shin Jeong
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids; May2005, Vol. 24 Issue 5-7, p1119-1121, 3p, 1 Diagram