Polyethylene glycol (PEG)-modified granulocyte-macrophage colony-stimulating factor (GM-CSF) with conserved biological activity

Autor: Malik F, Delgado C, Knüsli C, Ae, Irvine, Fisher D, Gillian Francis

Publikováno v: Europe PubMed Central

Polyethylene glycol (PEG) modification improves the pharmacological properties of proteins, usually extending plasma half-life and concomitantly increasing in vivo bioactivity, reducing both antigenicity and immunogenicity, and increasing solubility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cb6b49639e283af8bf14bf8b22844a3b
https://pubmed.ncbi.nlm.nih.gov/1505637

The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma.

Autor: Crawford LJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK. lisa.crawford@qub.ac.uk., Campbell DC; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Morgan JJ; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Lawson MA; Department of Oncology and Metabolism, Sheffield Myeloma Research Team, Medical School, University of Sheffield, Sheffield, UK., Down JM; Department of Oncology and Metabolism, Sheffield Myeloma Research Team, Medical School, University of Sheffield, Sheffield, UK., Chauhan D; Department of Medical Oncology, The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., McAvera RM; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Morris TC; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Hamilton C; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Krishnan A; Cell Biology Unit, University Medical Center Mainz, Mainz, Germany., Rajalingam K; Cell Biology Unit, University Medical Center Mainz, Mainz, Germany., Chantry AD; Department of Oncology and Metabolism, Sheffield Myeloma Research Team, Medical School, University of Sheffield, Sheffield, UK., Irvine AE; Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.

Publikováno v: Oncogene [Oncogene] 2020 Jul; Vol. 39 (27), pp. 5001-5014. Date of Electronic Publication: 2020 Jun 10.

Separation and Enrichment of Hematopoietic Stem Cells for CCN Studies.

Autor: Crawford LJ; Haematology Research Unit, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK., Irvine AE; Haematology Research Unit, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK. s.irvine@qub.ac.uk.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2017; Vol. 1489, pp. 261-271.

The role of the CCN family of proteins in blood cancers.

Autor: Crawford LJ; Haematology Research Unit, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Room OG/013, Belfast, BT9 7BL, Northern, Ireland., Irvine AE; Haematology Research Unit, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Room OG/013, Belfast, BT9 7BL, Northern, Ireland. s.irvine@qub.ac.uk.

Publikováno v: Journal of cell communication and signaling [J Cell Commun Signal] 2016 Sep; Vol. 10 (3), pp. 197-205. Date of Electronic Publication: 2016 Aug 03.

Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models.

Autor: Crawford LJ; Department of Haematology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK., Chan ET; Onyx Pharmaceuticals Inc., South San Francisco, CA, USA., Aujay M; Onyx Pharmaceuticals Inc., South San Francisco, CA, USA., Holyoake TL; Department of Experimental Haematology, Paul O'Gorman Leukaemia Research Centre, University of Glasgow, Glasgow, UK., Melo JV; 1] Department of Haematology, Centre for Cancer Biology, IMVS, Adelaide, South Australia, Australia [2] Department of Haematology, Imperial College London, London, UK., Jorgensen HG; Department of Experimental Haematology, Paul O'Gorman Leukaemia Research Centre, University of Glasgow, Glasgow, UK., Suresh S; Department of Haematology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK., Walker B; School of Pharmacy, Queen's University Belfast, Belfast, UK., Irvine AE; Department of Haematology, Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, UK.

Publikováno v: Oncogenesis [Oncogenesis] 2014 Mar 03; Vol. 3, pp. e90. Date of Electronic Publication: 2014 Mar 03.