Coordination of endothelial cell positioning and fate specification by the epicardium

Autor: Pearl Quijada, Michael A. Trembley, Adwiteeya Misra, Jacquelyn A. Myers, Cameron D. Baker, Marta Pérez-Hernández, Jason R. Myers, Ronald A. Dirkx, Ethan David Cohen, Mario Delmar, John M. Ashton, Eric M. Small

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

It remains unclear how spatial information controls endothelial cell identity and behavior in the developing heart. Here the authors perform single cell RNA sequencing at key developmental timepoints in mice to interrogate cellular contributions to c

Externí odkaz: https://doaj.org/article/490625a4402947fb92af5dfa14861595

Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics

Autor: Adwiteeya Misra, Cameron D. Baker, Elizabeth M. Pritchett, Kimberly N. Burgos Villar, John M. Ashton, Eric M. Small

Publikováno v: Journal of Cardiovascular Development and Disease, Vol 9, Iss 1, p 1 (2022)
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease; Volume 9; Issue 1; Pages: 1

The neonatal mammalian heart exhibits a remarkable regenerative potential, which includes fibrotic scar resolution and the generation of new cardiomyocytes. To investigate the mechanisms facilitating heart repair after apical resection in neonatal mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0df13328f147affbdde3ac09a28d2cc
https://www.mdpi.com/2308-3425/9/1/1

Abstract 548: Cellular Contributions to Neonatal Cardiac Regeneration

Autor: Ronald A. Dirkx, Ryan M. Burke, Eric M. Small, Adwiteeya Misra, Pearl Quijada

Publikováno v: Circulation Research. 127

While the neonatal mouse heart possesses a remarkable ability to regenerate up to a week after birth, the adult mammalian heart is susceptible to irreversible scar formation that impedes cardiac function. Such a scar is formed by the precocious depos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db2def9a9347adfcba39f5b8e0ddf345
https://doi.org/10.1161/res.127.suppl_1.548

Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging

Autor: Eric M. Small, Ronald A. Dirkx, Lissette S. Velasquez, Adwiteeya Misra, Deanne Mickelsen, Ryan M. Burke, Pearl Quijada, Janet K. Lighthouse

Publikováno v: Journal of molecular and cellular cardiology. 129

Serum response factor (SRF) and the SRF co-activators myocardin-related transcription factors (MRTFs) are essential for epicardium-derived progenitor cell (EPDC)-mobilization during heart development; however, the impact of developmental EPDC deficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd376f3f1e8cc7d3e2cc638760286a6
https://pubmed.ncbi.nlm.nih.gov/30771308

Similarities and differences in ablative and non-ablative iron oxide nanoparticle hyperthermia cancer treatment

Autor: Elliot J. Kastner, Courtney M. Mazur, James D. Petryk, Adwiteeya Misra, P. Jack Hoopes, Alicia A. Petryk

Publikováno v: Energy-based Treatment of Tissue and Assessment VIII.

The use of hyperthermia to treat cancer is well studied and has utilized numerous delivery techniques, including microwaves, radio frequency, focused ultrasound, induction heating, infrared radiation, warmed perfusion liquids (combined with chemother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9434911d42c874b84f2901da61ded1e8
https://doi.org/10.1117/12.2084041