Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Adwait Amod, Sathe"'
Autor:
Yan Liu, Adwait Amod Sathe, Kalil G. Abdullah, Samuel K. McBrayer, Steven H. Adams, Andrew J. Brenner, Kimmo J. Hatanpaa, Mariano S. Viapiano, Chao Xing, Jamie M. Walker, Timothy E. Richardson
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-11 (2022)
Abstract Diffusely infiltrating gliomas are among the most common central nervous system tumors in adults. Over the past decade, the subcategorization of these tumors has changed to include both traditional histologic features and more recently ident
Externí odkaz:
https://doaj.org/article/943d8c7aa6c44d918280294737c34ab0
Autor:
Abhimanyu Garg, Wee-Teik Keng, Zhenkang Chen, Adwait Amod Sathe, Chao Xing, Pavithira Devi Kailasam, Yanqiu Shao, Nicholas P. Lesner, Claire B. Llamas, Anil K. Agarwal, Prashant Mishra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Multiple genetic loci have been reported for progeroid syndromes. However, the molecular defects in some extremely rare forms of progeria have yet to be elucidated. Here, we report a 21-year-old man of Chinese ancestry who has an autosomal recessive
Externí odkaz:
https://doaj.org/article/486f4ee4357c45cca2ea1e35adcccde2
Autor:
Hao Xu, Shuting Zhang, Adwait Amod Sathe, Zhichun Jin, Jiani Guan, Wen Sun, Chao Xing, Hanwen Zhang, Bin Yan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
During mechanical force-induced alveolar bone remodeling, macrophage-mediated local inflammation plays a critical role. Yet, the detailed heterogeneity of macrophages is still unknown. Single-cell RNA sequencing was used to study the transcriptome he
Externí odkaz:
https://doaj.org/article/e60ef59659c94971962834021ba8e86a
Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
Autor:
Huocong Huang, Yuqing Zhang, Valerie Gallegos, Noah Sorrelle, Mohamed Medhat Zaid, Jason Toombs, Wenting Du, Steven Wright, Moriah Hagopian, Zhaoning Wang, Abdel Nasser Hosein, Adwait Amod Sathe, Chao Xing, Eugene J Koay, Kyla E Driscoll, Rolf A Brekken
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 11, Pp 1-20 (2019)
Abstract TGFβ is important during pancreatic ductal adenocarcinoma (PDA) progression. Canonical TGFβ signaling suppresses epithelial pancreatic cancer cell proliferation; as a result, inhibiting TGFβ has not been successful in PDA. In contrast, we
Externí odkaz:
https://doaj.org/article/7541d711b35f4c639b31ee32955e251b
Autor:
Kanish Mirchia, Adwait Amod Sathe, Jamie M. Walker, Yelena Fudym, Kristyn Galbraith, Mariano S. Viapiano, Robert J. Corona, Matija Snuderl, Chao Xing, Kimmo J. Hatanpaa, Timothy E. Richardson
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Since the discovery that IDH1/2 mutations confer a significantly better prognosis in astrocytomas, much work has been done to identify other molecular signatures to help further stratify lower-grade astrocytomas and glioblastomas, with the g
Externí odkaz:
https://doaj.org/article/1a198d62936c4db0b2102330f3677d74
Autor:
Antonio Fernandez-Perez, Adwait Amod Sathe, Minoti Bhakta, Kayla Leggett, Chao Xing, Nikhil Vilas Munshi
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2354-2369.e7 (2019)
Summary: Gata4, Hand2, Mef2c, and Tbx5 (GHMT) can reprogram transduced fibroblasts into induced pacemaker-like myocytes (iPMs), but the underlying mechanisms remain obscure. Here, we explore the role of Hand2 in iPM formation by using a combination o
Externí odkaz:
https://doaj.org/article/154c813dc5234dd7908ecb9758ce36c6
Autor:
Toan Nguyen, Jean-Philippe Brosseau, Lu Q. Le, Chao Xing, Adwait Amod Sathe, Yong Wang, Donald A. Glass
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-11 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Neurofibromatosis Type I (NF1) is a neurocutaneous genetic syndrome characterized by a wide spectrum of clinical presentations, including benign peripheral nerve sheath tumor called neurofibroma. These tumors originate from the Schwann cell lineage b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d152364048b922c02e4272079eea64f8
https://doaj.org/article/8889596d577b433e91c1f13df8ae59f6
https://doaj.org/article/8889596d577b433e91c1f13df8ae59f6
Autor:
Ryan J. Golden, Yang Xin Fu, Xiaowei Zhan, Bret M. Evers, Sojeong Jun, Carmen Behrens, Jingfei Zhu, Guanghua Xiao, Michael Peyton, Joshua T. Mendell, Vanessa Schmid, Chelsea M. Karacz, Adwait Amod Sathe, Kathryn A. O'Donnell, Chao Xing, Nicole Novaresi, Lin Zhong, Bethany Smith, Shruthy Suresh, Ignacio I. Wistuba, Zhuoyu Wen, John D. Minna, Yang Xie, Changzheng Lu, Beibei Chen
Publikováno v:
Nat Cancer
Cancer cells express high levels of programmed death ligand 1 (PD-L1), a ligand of the programmed cell death protein 1 (PD-1) receptor on T cells, allowing tumors to suppress T cell activity. Clinical trials utilizing antibodies that disrupt the PD-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f31a79badef7db84da2ac56d475065f
https://doi.org/10.1038/s43018-020-0056-0
https://doi.org/10.1038/s43018-020-0056-0
Autor:
David E. Gerber, Esra A. Akbay, Farjana J. Fattah, Kathryn H. Dao, Bipasha Mukherjee, Chao Xing, Amyn A. Habib, Boning Gao, Shanrong Zhang, Matthew E. Bender, Kemp H. Kernstine, Cheng Ming Chiang, Ke Gong, John D. Minna, Gao Guo, Michael Peyton, Dawen Zhao, Nishah Panchani, Adwait Amod Sathe, Sandeep Burma
Publikováno v:
Nature Cancer. 1:394-409
EGFR inhibition is an effective treatment in the minority of non-small cell lung cancer (NSCLC) cases harboring EGFR-activating mutations, but not in EGFR wild type (EGFRwt) tumors. Here, we demonstrate that EGFR inhibition triggers an antiviral defe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9724528c7c4d723be4111ff6bf382059
https://doi.org/10.1038/s43018-020-0048-0
https://doi.org/10.1038/s43018-020-0048-0
Autor:
Jianjing Yang, Haoqi Ni, Ke Wu, Chao Xing, Derek K. Smith, Dongdong Huang, Chun Li Zhang, Adwait Amod Sathe, Yu Tang, Meng Lu Liu, Sishi Pan, Qichuan Zhuge
Publikováno v:
Proc Natl Acad Sci U S A
Transfer RNAs (tRNAs) are products of RNA polymerase III (Pol III) and essential for mRNA translation and ultimately cell growth and proliferation. Whether and how individual tRNA genes are specifically regulated is not clear. Here, we report that SO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f7977e1418f2315ad132e6f4aa55da
https://doi.org/10.1073/pnas.1920200117
https://doi.org/10.1073/pnas.1920200117