S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

Autor: Adwait A Godbole, Sneha Gopalan, Thien-Kim Nguyen, Alexander L Munden, Dominique S Lui, Matthew J Fanelli, Paula Vo, Caroline A Lewis, Jessica B Spinelli, Thomas G Fazzio, Amy K Walker

Publikováno v: eLife, Vol 12 (2023)

Methylation is a widely occurring modification that requires the methyl donor S-adenosylmethionine (SAM) and acts in regulation of gene expression and other processes. SAM is synthesized from methionine, which is imported or generated through the 1-c

Externí odkaz: https://doaj.org/article/8ef70ae4ac0b4ed6b07168ee56561b9a

Author response: S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

Autor: Adwait A Godbole, Sneha Gopalan, Thien-Kim Nguyen, Alexander L Munden, Dominique S Lui, Matthew J Fanelli, Paula Vo, Caroline A Lewis, Jessica B Spinelli, Thomas G Fazzio, Amy K Walker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dada2e2413ba5997c0fadbb02b71e809
https://doi.org/10.7554/elife.79511.sa2

Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine.

Autor: Wei Ding, Daniel P Higgins, Dilip K Yadav, Adwait A Godbole, Read Pukkila-Worley, Amy K Walker

Publikováno v: PLoS Genetics, Vol 14, Iss 11, p e1007812 (2018)

S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production. SAM is hypothesized to link metabolism and chromatin modification, however, its role in acute gene reg

Externí odkaz: https://doaj.org/article/1ae22b80007049538872d0791c023e2e

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase

Autor: Clara Franch, Rosangela Frita, Joel S. Freundlich, Alexandre Vandeputte, Maria Rosalia Pasca, Courtney Veilleux, Mohamad Sabbah, Rajiv Kumar Jha, Beatrice Silvia Orena, Eik Hoffmann, Katarína Mikušová, Liliana Rodrigues, Adwait Anand Godbole, Lesley A. Mitchenall, Pradeep Kumar, Valakunja Nagaraja, Nathalie Deboosere, Stanislav Huszár, Priscille Brodin, Clara Aguilar-Pérez, José A. Aínsa, Sean Ekins, Riccardo Russo, Nancy D. Connell, Anthony Maxwell, Júlia Zemanová, Martin Forbak, Thomas J. Lane, Giorgia Mori

Publikováno v: Tuberculosis. 112:98-109

The search for compounds with biological activity for many diseases is turning increasingly to drug repurposing. In this study, we have focused on the European Union-approved antimalarial pyronaridine which was found to have in vitro activity against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1ba750c5c3cc0488b8f132f5da37c7
https://doi.org/10.1016/j.tube.2018.08.004

A new DNA sensor system for specific and quantitative detection of mycobacteria

Autor: Marianne Smedegaard Hede, Asger Givskov, Magnus Stougaard, Adwait Anand Godbole, Marie Bech Andersen, Donglu Shi, Lone Pødenphant, Oskar Franch, Jonas Thomsen, Charlotte Harmsen, Valakunja Nagaraja, Birgitta R. Knudsen, Yi-Ping Ho, Rodrigo Labouriau, Lærke Bay Marcussen, Niels Nørskov-Lauritsen, Christian Wejse, Xiao Han, Yilong Wang, Finn Skou Pedersen, Johanna Bertl

Publikováno v: Franch, O, Han, X, Marcussen, L, Jørgensen, A G, Andersen, M B, Godbole, A A, Harmsen, C, Nørskov-Lauritsen, N, Thomsen, J, Pedersen, F S, Wang, Y, Shi, D, Wejse, C, Pødenphant, L, Nagaraja, V, Bertl, J, Stougaard, M, Ho, Y-P, Hede, M S, Labouriau, R & Knudsen, B R 2019, ' A new DNA sensor system for specific and quantitative detection of mycobacteria ', Nanoscale, vol. 11, no. 2, pp. 587-597 . https://doi.org/10.1039/c8nr07850e

In the current study, we describe a novel DNA sensor system for specific and quantitative detection of mycobacteria, which is the causative agent of tuberculosis. Detection is achieved by using the enzymatic activity of the mycobacterial encoded enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaaa72a7a55a0f17b029952b53a264d
https://pubmed.ncbi.nlm.nih.gov/30556557