PROTEOMAS: a workflow enabling harmonized proteomic meta-analysis and proteomic signature mapping

Autor: Aileen Bahl, Celine Ibrahim, Kristina Plate, Andrea Haase, Jörn Dengjel, Penny Nymark, Verónica I. Dumit

Publikováno v: Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-17 (2023)

Abstract Toxicological evaluation of substances in regulation still often relies on animal experiments. Understanding the substances’ mode-of-action is crucial to develop alternative test strategies. Omics methods are promising tools to achieve thi

Externí odkaz: https://doaj.org/article/edab0f66a8a0400898a23df3eb128876

Towards a systematic use of effect biomarkers in population and occupational biomonitoring

Autor: Maryam Zare Jeddi, Nancy B. Hopf, Susana Viegas, Anna Bal Price, Alicia Paini, Christoph van Thriel, Emilio Benfenati, Sophie Ndaw, Jos Bessems, Peter A. Behnisch, Gabriele Leng, Radu-Corneliu Duca, Hans Verhagen, Francesco Cubadda, Lorraine Brennan, Imran Ali, Arthur David, Vicente Mustieles, Mariana F. Fernandez, Henriqueta Louro, Robert Pasanen-Kase

Publikováno v: Environment International, Vol 146, Iss , Pp 106257- (2021)

Effect biomarkers can be used to elucidate relationships between exposure to environmental chemicals and their mixtures with associated health outcomes, but they are often underused, as underlying biological mechanisms are not understood. We aim to p

Externí odkaz: https://doaj.org/article/3dd9c2e6f351454eb1a78e333e390a0f

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Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials

Autor: M.J.B. Amorim, W. Peijnenburg, D. Greco, L.A. Saarimäki, V.I. Dumit, A. Bahl, A. Haase, L. Tran, J. Hackermüller, S. Canzler, J.J. Scott-Fordsmand

Publikováno v: Amorim, M J B, Peijnenburg, W, Greco, D, Saarimäki, L A, Dumit, V I, Bahl, A, Haase, A, Tran, L, Hackermüller, J, Canzler, S & Scott-Fordsmand, J J 2023, ' Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials ', Nano Today, vol. 48 . https://doi.org/10.1016/j.nantod.2022.101735

Ideally, a Systems Toxicology (ST) approach is aimed at by (eco)toxicologists, i.e. a multidisciplinary area incorporating classical toxicological concepts with omics technologies, and the understanding of this through computational data sciences, ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895482ec9fb9cda368e43e4e31f4d899
https://pure.au.dk/portal/da/publications/systems-toxicology-to-advance-human-and-environmental-hazard-assessment-a-roadmap-for-advanced-materials(2e37d8b3-86b0-4fc8-b17e-2bfd1b4c812f).html

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac

Autor: Jung-Hwa Oh, Saravanakumar Selvaraj, Jürgen Borlak

Publikováno v: Archives of Toxicology

Many drugs have the potential to cause drug-induced liver injury (DILI); however, underlying mechanisms are diverse. The concept of adverse outcome pathways (AOPs) has become instrumental for risk assessment of drug class effects. We report AOPs spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a83d1548f65a19cbd98f30804abad6
http://europepmc.org/articles/PMC7395045