Zobrazeno 1 - 10
of 2 714
pro vyhledávání: '"Adverse outcome pathway"'
Autor:
Domenico Gadaleta, Marina Garcia de Lomana, Eva Serrano-Candelas, Rita Ortega-Vallbona, Rafael Gozalbes, Alessandra Roncaglioni, Emilio Benfenati
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract The adverse outcome pathway (AOP) concept has gained attention as a way to explore the mechanism of chemical toxicity. In this study, quantitative structure–activity relationship (QSAR) models were developed to predict compound activity to
Externí odkaz:
https://doaj.org/article/f64a73920b77456f89cbc33ac1b0126b
Autor:
Yong Joo Park, Ha Ryong Kim, Jun Woo Kim, Jong-Hyun Lee, Younghee Kim, Jungyun Lim, Yong-Wook Baek, Kyu Hyuck Chung
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 287, Iss , Pp 117222- (2024)
In this study, we investigated the potential mechanisms by which polyhexamethylene guanidine phosphate (PHMG-p), a known respiratory irritant, may contribute to lung cancer development. Using the adverse outcome pathway (AOP) framework, we analyzed e
Externí odkaz:
https://doaj.org/article/4bac41ae5509424cb55223bce6f261bf
Autor:
Victoria Ledbetter, Scott Auerbach, Logan J. Everett, Beena Vallanat, Anna Lowit, Gregory Akerman, William Gwinn, Leah C. Wehmas, Michael F. Hughes, Michael Devito, J. Christopher Corton
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Current methods for cancer risk assessment are resource-intensive and not feasible for most of the thousands of untested chemicals. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression b
Externí odkaz:
https://doaj.org/article/b05c465a5b4645b5b3f97f1d7d895f25
Autor:
Lynne T. Haber, Mark A. Bradley, Amanda N. Buerger, Holger Behrsing, Sabina Burla, Phillip W. Clapp, Scott Dotson, Casey Fisher, Keith R. Genco, Francis H. Kruszewski, Shaun D. McCullough, Kathryn E. Page, Vivek Patel, Nathan Pechacek, Clive Roper, Monita Sharma, Annie M. Jarabek
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The use of in vitro new approach methodologies (NAMs) to assess respiratory irritation depends on several factors, including the specifics of exposure methods and cell/tissue-based test systems. This topic was examined in the context of human health
Externí odkaz:
https://doaj.org/article/ca72051be402475ab543842c66886536
Autor:
Imran Ahamed Khan, Ting Yu, Yong Li, Chengzhang Hu, Xiaoyu Zhao, Qing Wei, Yufang Zhong, Ming Yang, Jinliang Liu, Zhong Chen
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 284, Iss , Pp 116905- (2024)
Lanthanide-doped upconversion nanoparticles (Ln-UCNPs) have been considered promising materials for various fields, such as biomedical and industrial applications. However, data and reports regarding its toxicity and environmental risks are scarce. U
Externí odkaz:
https://doaj.org/article/5781d5297eb94a00ace7fe439c126a88
Autor:
Imke Van Dingenen, Emma Andersen, Sina Volz, Monica Christiansen, Jiří Novák, Ann-Cathrin Haigis, Emma Stacy, Brett R. Blackwell, Daniel L. Villeneuve, Lucia Vergauwen, Klára Hilscherová, Henrik Holbech, Dries Knapen
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 284, Iss , Pp 116995- (2024)
Environmental pollutants capable of interfering with the thyroid hormone (TH) system increasingly raise concern for both human and environmental health. Recently, resorcinol has received attention as a compound of concern due to its endocrine disrupt
Externí odkaz:
https://doaj.org/article/72b38cbdd3be4fd3ab8bb5e476c8e2be
Publikováno v:
Environment International, Vol 191, Iss , Pp 108995- (2024)
Traditional methods for identifying endocrine-disrupting chemicals (EDCs) that activate androgen receptors (AR) are costly, time-consuming, and low-throughput. This study developed a knowledge-based deep neural network model (AR-DNN) to predict AR-me
Externí odkaz:
https://doaj.org/article/510c760ce9fb46bb95c5b2fc07f9add8
Autor:
Xiao Gou, Mingming Tian, Lu Yan, Pu Xia, Huimin Ji, Haoyue Tan, Wei Shi, Hongxia Yu, Xiaowei Zhang
Publikováno v:
Environment International, Vol 191, Iss , Pp 108962- (2024)
Exposed to ubiquitously perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) has been associated with non-alcoholic fatty liver disease (NAFLD), yet the underlying molecular mechanism remains elusive. The extrapolation of empirical stud
Externí odkaz:
https://doaj.org/article/537f0b403e2049189bff8eb0762da428
Autor:
Cheng Cheng, Bowen Fan, Yi Yang, Peiwen Wang, Meng Wu, Haibo Xia, Binafsha Manzoor Syed, Hao Wu, Qizhan Liu
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 283, Iss , Pp 116809- (2024)
Environmental pollutants are considered as a cause of tumorigenesis, but approaches to assess their risk of causing tumors remain insufficient. As an alternative approach, the adverse outcome pathway (AOP) framework is used to assess the risk of tumo
Externí odkaz:
https://doaj.org/article/3499f6ff648b4b0e93ac42fad89f0ac6
Autor:
European Food Safety Authority (EFSA), Kevin M. Crofton, Martin Paparella, Anna Price, Iris Mangas, Laura Martino, Andrea Terron, Antonio Hernández‐Jerez
Publikováno v:
EFSA Journal, Vol 22, Iss 8, Pp n/a-n/a (2024)
Abstract The adverse outcome pathway (AOP) framework serves as a practical tool for organising scientific knowledge that can be used to infer cause–effect relationships between stressor events and toxicity outcomes in intact organisms. However, a m
Externí odkaz:
https://doaj.org/article/c3b3bb85a2de473da5a703e2851b6664